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Reliable uncertainty quantification (UQ) is essential when employing large language models (LLMs) in high-risk domains such as clinical question answering (QA). In this work, we evaluate uncertainty estimation methods for clinical QA…

Computation and Language · Computer Science 2026-01-27 Alberto Testoni , Iacer Calixto

Large language models (LLMs) are increasingly used for diagnostic tasks in medicine. In clinical practice, the correct diagnosis can rarely be immediately inferred from the initial patient presentation alone. Rather, reaching a diagnosis…

Artificial Intelligence · Computer Science 2026-02-20 Hui Min Wong , Philip Heesen , Pascal Janetzky , Martin Bendszus , Stefan Feuerriegel

Large Language Models (LLMs) are versatile and demonstrate impressive generalization ability by mining and learning information from extensive unlabeled text. However, they still exhibit reasoning mistakes, often stemming from knowledge…

Computation and Language · Computer Science 2024-08-22 Kai Xiong , Xiao Ding , Li Du , Jiahao Ying , Ting Liu , Bing Qin , Yixin Cao

The rise of large language models (LLMs) and their tight integration into our daily life make it essential to dedicate efforts towards their trustworthiness. Uncertainty quantification for LLMs can establish more human trust into their…

Computation and Language · Computer Science 2026-05-06 Daniel Yang , Yao-Hung Hubert Tsai , Makoto Yamada

The rapid advancement of large language models (LLMs) has opened new boundaries in the extraction and synthesis of medical knowledge, particularly within evidence synthesis. This paper reviews the state-of-the-art applications of LLMs in…

Large Language Models have demonstrated remarkable capabilities in natural language processing, yet their decision-making processes often lack transparency. This opaqueness raises significant concerns regarding trust, bias, and model…

Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios.…

Computation and Language · Computer Science 2026-01-06 Qipeng Wang , Rui Sheng , Yafei Li , Huamin Qu , Yushi Sun , Min Zhu

Large Language Models (LLMs) have been transformative across many domains. However, hallucination, i.e., confidently outputting incorrect information, remains one of the leading challenges for LLMs. This raises the question of how to…

Computation and Language · Computer Science 2026-03-19 Toghrul Abbasli , Kentaroh Toyoda , Yuan Wang , Leon Witt , Muhammad Asif Ali , Yukai Miao , Dan Li , Qingsong Wei

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Problem-solving has been a fundamental driver of human progress in numerous domains. With advancements in artificial intelligence, Large Language Models (LLMs) have emerged as powerful tools capable of tackling complex problems across…

Machine Learning · Computer Science 2025-05-07 Da Zheng , Lun Du , Junwei Su , Yuchen Tian , Yuqi Zhu , Jintian Zhang , Lanning Wei , Ningyu Zhang , Huajun Chen

Large Language Models (LLMs) have shown growing potential in molecular sciences, but they often produce chemically inaccurate descriptions and struggle to recognize or justify potential errors. This raises important concerns about their…

Chemical Physics · Physics 2025-10-29 Yuyang Wu , Jinhui Ye , Shuhao Zhang , Lu Dai , Yonatan Bisk , Olexandr Isayev

Medical document analysis plays a crucial role in extracting essential clinical insights from unstructured healthcare records, supporting critical tasks such as differential diagnosis. Determining the most probable condition among…

Artificial Intelligence · Computer Science 2025-06-25 Lei Kang , Xuanshuo Fu , Oriol Ramos Terrades , Javier Vazquez-Corral , Ernest Valveny , Dimosthenis Karatzas

The rapid rise of large language models (LLMs) is reshaping the landscape of automatic assessment in education. While these systems demonstrate substantial advantages in adaptability to diverse question types and flexibility in output…

Large language models (LLMs) have demonstrated impressive capabilities in natural language processing. However, their internal mechanisms are still unclear and this lack of transparency poses unwanted risks for downstream applications.…

Computation and Language · Computer Science 2023-11-30 Haiyan Zhao , Hanjie Chen , Fan Yang , Ninghao Liu , Huiqi Deng , Hengyi Cai , Shuaiqiang Wang , Dawei Yin , Mengnan Du

Deep learning methods for ophthalmic diagnosis have shown considerable success in tasks like segmentation and classification. However, their widespread application is limited due to the models being opaque and vulnerable to making a wrong…

Image and Video Processing · Electrical Eng. & Systems 2021-01-29 Amitojdeep Singh , Sourya Sengupta , Mohammed Abdul Rasheed , Varadharajan Jayakumar , Vasudevan Lakshminarayanan

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external…

Machine Learning · Computer Science 2024-08-26 Zhihao Yu , Yujie Jin , Yongxin Xu , Xu Chu , Yasha Wang , Junfeng Zhao

The rise of Large Language Models (LLMs), such as LLaMA and ChatGPT, has opened new opportunities for enhancing recommender systems through improved explainability. This paper provides a systematic literature review focused on leveraging…

Information Retrieval · Computer Science 2025-01-22 Alan Said

Despite the outstanding performance of large language models (LLMs) across various NLP tasks, hallucinations in LLMs--where LLMs generate inaccurate responses--remains as a critical problem as it can be directly connected to a crisis of…

Computation and Language · Computer Science 2025-07-22 Minsuh Joo , Hyunsoo Cho

Despite widespread success in language understanding and generation, large language models (LLMs) exhibit unclear and often inconsistent behavior when faced with tasks that require probabilistic reasoning. In this work, we present the first…

Computation and Language · Computer Science 2025-09-29 Mobina Pournemat , Keivan Rezaei , Gaurang Sriramanan , Arman Zarei , Jiaxiang Fu , Yang Wang , Hamid Eghbalzadeh , Soheil Feizi

Large language models (LLMs) often produce confident yet incorrect answers, which can lead to risky failures in real-world applications. We study whether post-training can make a model's self-assessment explicit: when the model is…

Machine Learning · Computer Science 2026-05-15 Junyu Guo , Shangding Gu , Ming Jin , Costas Spanos , Javad Lavaei