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Large Language Models (LLMs) have shown promise in clinical applications through prompt engineering, allowing flexible clinical predictions. However, they struggle to produce reliable prediction probabilities, which are crucial for…

Artificial Intelligence · Computer Science 2024-12-05 Bowen Gu , Rishi J. Desai , Kueiyu Joshua Lin , Jie Yang

Unlike nature image classification where groundtruth label is explicit and of no doubt, physicians commonly interpret medical image conditioned on certainty like using phrase "probable" or "likely". Existing medical image datasets either…

Machine Learning · Computer Science 2025-11-21 Kunyu Zhang , Fukang Ge , Binyang Wang , Yingke Chen , Kazuma Kobayashi , Lin Gu , Jinhao Bi , Yingying Zhu

As artificial intelligence (AI) systems, particularly large language models (LLMs), become increasingly integrated into decision-making processes, the ability to trust their outputs is crucial. To earn human trust, LLMs must be well…

Machine Learning · Computer Science 2025-02-14 Mark Steyvers , Heliodoro Tejeda , Aakriti Kumar , Catarina Belem , Sheer Karny , Xinyue Hu , Lukas Mayer , Padhraic Smyth

Medical imaging plays a pivotal role in diagnosis and treatment in clinical practice. Inspired by the significant progress in automatic image captioning, various deep learning (DL)-based methods have been proposed to generate radiology…

Computer Vision and Pattern Recognition · Computer Science 2022-02-04 Yixin Wang , Zihao Lin , Zhe Xu , Haoyu Dong , Jiang Tian , Jie Luo , Zhongchao Shi , Yang Zhang , Jianping Fan , Zhiqiang He

The development of large language models (LLMs) has brought unprecedented possibilities for artificial intelligence (AI) based medical diagnosis. However, the application perspective of LLMs in real diagnostic scenarios is still unclear…

Computation and Language · Computer Science 2024-05-21 Zhoujian Sun , Cheng Luo , Ziyi Liu , Zhengxing Huang

Large Language Models (LLMs) have shown impressive potential to simulate human behavior. We identify a fundamental challenge in using them to simulate experiments: when LLM-simulated subjects are blind to the experimental design (as is…

Artificial Intelligence · Computer Science 2025-11-25 George Gui , Olivier Toubia

Large language models have exhibited impressive performance across a broad range of downstream tasks in natural language processing. However, how a language model predicts the next token and generates content is not generally understandable…

The potential of large language models (LLMs) as decision support tools is increasingly being explored in fields such as business, engineering, and medicine, which often face challenging tasks of decision-making under uncertainty. In this…

Artificial Intelligence · Computer Science 2024-10-14 Ollie Liu , Deqing Fu , Dani Yogatama , Willie Neiswanger

Medicine is rife with high-stakes uncertainty. Doctors routinely make clinical judgments and decisions that juggle many fundamental unknowns, like predictions about what might be causing a patients' symptoms or decisions about what…

Large language models (LLMs) often generate fluent but factually incorrect outputs, known as hallucinations, which undermine their reliability in real-world applications. While uncertainty estimation has emerged as a promising strategy for…

Machine Learning · Computer Science 2025-05-13 Pei-Fu Guo , Yun-Da Tsai , Shou-De Lin

Large Language Models (LLMs) have achieved remarkable success in natural language tasks, yet understanding their reasoning processes remains a significant challenge. We address this by introducing XplainLLM, a dataset accompanying an…

Computation and Language · Computer Science 2024-09-24 Zichen Chen , Jianda Chen , Ambuj Singh , Misha Sra

Large language models (LLMs) are being explored for diagnostic decision support, yet their ability to estimate pre-test probabilities, vital for clinical decision-making, remains limited. This study evaluates two LLMs, Mistral-7B and…

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

In-context learning has emerged as a groundbreaking ability of Large Language Models (LLMs) and revolutionized various fields by providing a few task-relevant demonstrations in the prompt. However, trustworthy issues with LLM's response,…

Computation and Language · Computer Science 2024-04-01 Chen Ling , Xujiang Zhao , Xuchao Zhang , Wei Cheng , Yanchi Liu , Yiyou Sun , Mika Oishi , Takao Osaki , Katsushi Matsuda , Jie Ji , Guangji Bai , Liang Zhao , Haifeng Chen

Large Language Models (LLMs) have demonstrated remarkable performance in solving math problems, a hallmark of human intelligence. Despite high success rates on current benchmarks; however, these often feature simple problems with only one…

Artificial Intelligence · Computer Science 2024-11-19 Kuei-Chun Kao , Ruochen Wang , Cho-Jui Hsieh

Large Language Models (LLMs) are increasingly deployed for clinical reasoning tasks, which inherently require eliciting calibrated probabilistic beliefs based on available evidence. However, real-world clinical data are frequently…

Artificial Intelligence · Computer Science 2026-03-19 Yuta Kobayashi , Vincent Jeanselme , Shalmali Joshi

The rapid advancements in Vision Language Models (VLMs) have prompted the development of multi-modal medical assistant systems. Despite this progress, current models still have inherent probabilistic uncertainties, often producing erroneous…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Xiao Liang , Di Wang , Zhicheng Jiao , Ronghan Li , Pengfei Yang , Quan Wang , Tat-Seng Chua

Uncertainty decomposition refers to the task of decomposing the total uncertainty of a predictive model into aleatoric (data) uncertainty, resulting from inherent randomness in the data-generating process, and epistemic (model) uncertainty,…

Computation and Language · Computer Science 2024-06-12 Bairu Hou , Yujian Liu , Kaizhi Qian , Jacob Andreas , Shiyu Chang , Yang Zhang

Vision-Language Models (VLMs) have achieved remarkable progress in complex visual understanding across scientific and reasoning tasks. While performance benchmarking has advanced our understanding of these capabilities, the critical…

Artificial Intelligence · Computer Science 2026-01-27 Asif Azad , Mohammad Sadat Hossain , MD Sadik Hossain Shanto , M Saifur Rahman , Md Rizwan Parvez

In many high-risk machine learning applications it is essential for a model to indicate when it is uncertain about a prediction. While large language models (LLMs) can reach and even surpass human-level accuracy on a variety of benchmarks,…

Computation and Language · Computer Science 2024-06-06 Evan Becker , Stefano Soatto
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