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For prostate cancer patients, the Gleason score is one of the most important prognostic factors, potentially determining treatment independent of the stage. However, Gleason scoring is based on subjective microscopic examination of tumor…

In this study, an automated three dimensional (3D) deep segmentation approach for detecting gliomas in 3D pre-operative MRI scans is proposed. Then, a classi-fication algorithm based on random forests, for survival prediction is presented.…

Image and Video Processing · Electrical Eng. & Systems 2019-11-20 Mehdi Amian , Mohammadreza Soltaninejad

Automatic segmentation of medical images with DL algorithms has proven to be highly successful. With most of these algorithms, inter-observer variation is an acknowledged problem, leading to sub-optimal results. This problem is even more…

Computer Vision and Pattern Recognition · Computer Science 2021-02-17 Anjali Balagopal , Howard Morgan , Michael Dohopoloski , Ramsey Timmerman , Jie Shan , Daniel F. Heitjan , Wei Liu , Dan Nguyen , Raquibul Hannan , Aurelie Garant , Neil Desai , Steve Jiang

Non-invasive radiological-based lesion characterization and identification, e.g., to differentiate cancer subtypes, has long been a major aim to enhance oncological diagnosis and treatment procedures. Here we study a specific population of…

Computer Vision and Pattern Recognition · Computer Science 2020-09-01 Yuankai Huo , Jinzheng Cai , Chi-Tung Cheng , Ashwin Raju , Ke Yan , Bennett A. Landman , Jing Xiao , Le Lu , Chien-Hung Liao , Adam P. Harrison

Semi-supervised learning in medical image segmentation leverages unlabeled data to reduce annotation burdens through consistency learning. However, current methods struggle with class imbalance and high uncertainty from pathology…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Maregu Assefa , Muzammal Naseer , Iyyakutti Iyappan Ganapathi , Syed Sadaf Ali , Mohamed L Seghier , Naoufel Werghi

Background: Radiomics shows promise in characterizing glioblastoma, but its added value over clinical and molecular predictors has yet to be proven. This study assessed the added value of conventional radiomics (CR) and deep learning (DL)…

Current medical image analysis systems are typically task-specific, requiring separate models for classification and segmentation, and lack the flexibility to support user-defined workflows. To address these challenges, we introduce…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Shadman Sobhan , Kazi Abrar Mahmud , Abduz Zami

Current deep learning-based models typically analyze medical images in either 2D or 3D albeit disregarding volumetric information or suffering sub-optimal performance due to the anisotropic resolution of MR data. Furthermore, providing an…

Image and Video Processing · Electrical Eng. & Systems 2024-07-02 Alex Ling Yu Hung , Haoxin Zheng , Kai Zhao , Kaifeng Pang , Demetri Terzopoulos , Kyunghyun Sung

High-precision medical diagnosis relies not only on static imaging features but also on the implicit diagnostic memory experts instantly invoke during image interpretation. We pinpoint a fundamental cognitive misalignment in medical VLMs…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Chunzheng Zhu , Jiaqi Zeng , Junyu Jiang , Jianxin Lin , Yijun Wang

Liver steatosis is known as the abnormal accumulation of lipids within cells. An accurate quantification of steatosis area within the liver histopathological microscopy images plays an important role in liver disease diagnosis and…

Image and Video Processing · Electrical Eng. & Systems 2019-11-19 Xiaoyuan Guo , Fusheng Wang , George Teodorou , Alton B. Farris , Jun Kong

Detecting and segmenting brain metastases is a tedious and time-consuming task for many radiologists, particularly with the growing use of multi-sequence 3D imaging. This study demonstrates automated detection and segmentation of brain…

Image and Video Processing · Electrical Eng. & Systems 2019-12-30 Endre Grøvik , Darvin Yi , Michael Iv , Elisabeth Tong , Daniel L. Rubin , Greg Zaharchuk

Ovarian cancer is the most lethal gynecologic malignancy: around 60% of patients are diagnosed at an advanced stage, with an associated 5-year survival rate of about 30%. Early identification of non-responders to neoadjuvant chemotherapy…

The accurate diagnosis and molecular profiling of colorectal cancers are critical for planning the best treatment options for patients. Microsatellite instability (MSI) or mismatch repair (MMR) status plays a vital role in appropriate…

Quantitative Methods · Quantitative Biology 2022-04-27 Ruqayya Awan , Mohammed Nimir , Shan E Ahmed Raza , Mohsin Bilal , Johannes Lotz , David Snead , Andrew Robinson , Nasir Rajpoot

Contrast-enhanced Computed Tomography (CT) is important for diagnosis and treatment planning for various medical conditions. Deep learning (DL) based segmentation models may enable automated medical image analysis for detecting and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-10 Eirik A. Østmo , Kristoffer K. Wickstrøm , Keyur Radiya , Michael C. Kampffmeyer , Karl Øyvind Mikalsen , Robert Jenssen

Locoregional recurrences (LRR) are still a frequent site of treatment failure for head and neck squamous cell carcinoma (HNSCC) patients. Identification of high risk subvolumes based on pretreatment imaging is key to biologically targeted…

Liver cancer is a leading cause of cancer-related mortality worldwide, with its high genetic heterogeneity complicating diagnosis and treatment. This study introduces DLSOM, a deep learning framework utilizing stacked autoencoders to…

Genomics · Quantitative Biology 2024-12-18 Fabio Zamio

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Many complex Deep Learning models are used with different variations for various prognostication tasks. The higher learning parameters not necessarily ensure great accuracy. This can be solved by considering changes in very deep models with…

Machine Learning · Computer Science 2022-06-15 Abhishek Gupta , Sruthi Nair , Raunak Joshi , Vidya Chitre

Vision-Language Foundation Models (VLFM) have shown a tremendous increase in performance in terms of generating high-resolution, photorealistic natural images. While VLFMs show a rich understanding of semantic content across modalities,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Parham Saremi , Amar Kumar , Mohamed Mohamed , Zahra TehraniNasab , Tal Arbel

Purpose. High-grade serous ovarian carcinoma (HGSOC) is characterized by pronounced biological and spatial heterogeneity and is frequently diagnosed at an advanced stage. Neoadjuvant chemotherapy (NACT) followed by delayed primary surgery…

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