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Medical language models must be updated as evidence and terminology evolve, yet sequential updating can trigger catastrophic forgetting. Although biomedical NLP has many static benchmarks, no unified, task-diverse benchmark exists for…

Artificial Intelligence · Computer Science 2026-03-18 Min Zeng , Shuang Zhou , Zaifu Zhan , Rui Zhang

Evaluating the performance of Multi-modal Large Language Models (MLLMs), integrating both point cloud and language, presents significant challenges. The lack of a comprehensive assessment hampers determining whether these models truly…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Junjie Zhang , Tianci Hu , Xiaoshui Huang , Yongshun Gong , Dan Zeng

Deploying large language models (LLMs) locally on mobile devices is advantageous in scenarios where transmitting data to remote cloud servers is either undesirable due to privacy concerns or impractical due to network connection. Recent…

Multimodal Large Language Models (MLLMs) may memorize sensitive cross-modal information during pretraining. However, existing MLLM unlearning benchmarks rely on synthetic knowledge injection or complete subject-level deletion, which fail to…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Jiahui Guang , Zexun Zhan , Zhenlin Xu , Cuiyun Gao , Haiyan Wang , Jing Li , Zhaoquan Gu , Yanchun Zhang

Large Language Models (LLMs)-based agents have made impressive progress in reasoning and tool use, enabling them to solve complex tasks. However, their ability to proactively collaborate with users, especially when goals are vague,…

While large language models (LLMs) have become the de facto framework for literature-related tasks, they still struggle to function as domain-specific literature agents due to their inability to connect pieces of knowledge and reason across…

Digital Libraries · Computer Science 2026-03-03 Andreas Varvarigos , Ali Maatouk , Jiasheng Zhang , Ngoc Bui , Jialin Chen , Leandros Tassiulas , Rex Ying

Variant and gene interpretation are fundamental to personalized medicine and translational biomedicine. However, traditional approaches are manual and labor-intensive. Generative language models (LMs) can facilitate this process,…

Artificial Intelligence · Computer Science 2025-10-15 Owen Queen , Harrison G. Zhang , James Zou

Language model benchmarks are pervasive and computationally-efficient proxies for real-world performance. However, many recent works find that benchmarks often fail to predict real utility. Towards bridging this gap, we introduce benchmark…

Artificial Intelligence · Computer Science 2026-05-28 Marco Gutierrez , Xinyi Leng , Hannah Cyberey , Jonathan Richard Schwarz , Ahmed Alaa , Thomas Hartvigsen

Multimodal Large Language Model (MLLM) relies on the powerful LLM to perform multimodal tasks, showing amazing emergent abilities in recent studies, such as writing poems based on an image. However, it is difficult for these case studies to…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Chaoyou Fu , Peixian Chen , Yunhang Shen , Yulei Qin , Mengdan Zhang , Xu Lin , Jinrui Yang , Xiawu Zheng , Ke Li , Xing Sun , Yunsheng Wu , Rongrong Ji , Caifeng Shan , Ran He

Predicting protein complex structures is essential for protein function analysis, protein design, and drug discovery. While AI methods like AlphaFold can predict accurate structural models for many protein complexes, reliably estimating the…

Biomolecules · Quantitative Biology 2025-05-30 Pawan Neupane , Jian Liu , Jianlin Cheng

We present HealthBench, an open-source benchmark measuring the performance and safety of large language models in healthcare. HealthBench consists of 5,000 multi-turn conversations between a model and an individual user or healthcare…

Large language models (LLMs) have shown significant promise across various medical applications, with ophthalmology being a notable area of focus. Many ophthalmic tasks have shown substantial improvement through the integration of LLMs.…

Computation and Language · Computer Science 2025-02-04 Chengfeng Zhou , Ji Wang , Juanjuan Qin , Yining Wang , Ling Sun , Weiwei Dai

Large Language Models (LLMs) have training corpora containing large amounts of program code, greatly improving the model's code comprehension and generation capabilities. However, sound comprehensive research on detecting program…

Cryptography and Security · Computer Science 2024-08-22 Yu Liu , Lang Gao , Mingxin Yang , Yu Xie , Ping Chen , Xiaojin Zhang , Wei Chen

Test set contamination, wherein test data from a benchmark ends up in a newer model's training set, is a well-documented obstacle for fair LLM evaluation and can quickly render benchmarks obsolete. To mitigate this, many recent benchmarks…

Equation discovery from data is a central challenge in machine learning for science, which requires the recovery of concise symbolic expressions that govern complex physical and geometric phenomena. Recent large language model (LLM)…

Machine Learning · Computer Science 2026-03-04 Sanchit Kabra , Shobhnik Kriplani , Parshin Shojaee , Chandan K. Reddy

We present INTEGRALBENCH, a focused benchmark designed to evaluate Large Language Model (LLM) performance on definite integral problems. INTEGRALBENCH provides both symbolic and numerical ground truth solutions with manual difficulty…

Artificial Intelligence · Computer Science 2025-07-30 Bintao Tang , Xin Yang , Yuhao Wang , Zixuan Qiu , Zimo Ji , Wenyuan Jiang

Recent advancements in large language models (LLMs) have significantly enhanced text generation capabilities, yet evaluating their performance in generative writing remains a challenge. Existing benchmarks primarily focus on generic text…

Artificial Intelligence · Computer Science 2025-12-01 Yuning Wu , Jiahao Mei , Ming Yan , Chenliang Li , Shaopeng Lai , Yuran Ren , Zijia Wang , Ji Zhang , Mengyue Wu , Qin Jin , Fei Huang

Medical data poses a daunting challenge for AI algorithms: it exists in many different modalities, experiences frequent distribution shifts, and suffers from a scarcity of examples and labels. Recent advances, including transformers and…

Recent advances in large language models (LLMs) and vision-language models (LVLMs) have shown promise across many tasks, yet their scientific reasoning capabilities remain untested, particularly in multimodal settings. We present…

Machine Learning · Computer Science 2025-06-03 Xinwu Ye , Chengfan Li , Siming Chen , Wei Wei , Xiangru Tang

Protein language models (pLMs) have shown strong potential for zero-shot prediction of missense variant effects, yet systematic benchmarking on viral proteins remains limited, a critical gap given the need for proactive tools that can…

Quantitative Methods · Quantitative Biology 2026-05-20 Yichen Zhou , Jonathan Golob , Amir Karimi , Stefan Bauer , Patrick Schwab