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Accurate prediction of thermodynamic properties is pivotal in chemical engineering for optimizing process efficiency and sustainability. Physical group-contribution (GC) methods are widely employed for this purpose but suffer from…

Chemical Physics · Physics 2025-01-28 Nicolas Hayer , Thorsten Wendel , Stephan Mandt , Hans Hasse , Fabian Jirasek

Calibrating mathematical models of biological processes is essential for achieving predictive accuracy and gaining mechanistic insight. However, this task remains challenging due to limited and noisy data, significant biological…

Quantitative Methods · Quantitative Biology 2025-12-04 Piotr Gwiazda , Alexey Kazarnikov , Anna Marciniak-Czochra , Zuzanna Szymańska

Large pre-trained models have demonstrated extensive applications across various fields. However, fine-tuning these models for specific downstream tasks demands significant computational resources and storage. One fine-tuning method,…

Machine Learning · Computer Science 2025-07-02 Xuanbo Liu , Liu Liu , Fuxiang Wu , Fusheng Hao , Xianglong Liu

We introduce a novel nonlinear Kalman filter that utilizes reparametrization gradients. The widely used parametric approximation is based on a jointly Gaussian assumption of the state-space model, which is in turn equivalent to minimizing…

Machine Learning · Computer Science 2023-03-09 San Gultekin , Brendan Kitts , Aaron Flores , John Paisley

Accurate phase equilibria are foundational to alloy design because they encode the underlying thermodynamics governing stability, transformations, and processing windows. However, while the CALculation of Phase Diagrams (CALPHAD) provides a…

Machine Learning · Computer Science 2026-04-21 Eunjeong Park , Amrita Basak

Cardiac muscle tissue during relaxation is commonly modelled as a hyperelastic material with strongly nonlinear and anisotropic stress response. Adapting the behavior of such a model to experimental or patient data gives rise to a parameter…

Tissues and Organs · Quantitative Biology 2016-03-16 Gabriel Balaban , Martin S. Alnæs , Joakim Sundnes , Marie E. Rognes

The multiscale model combining the multiconfigurational self-consistent field (MCSCF) method with the fully atomistic polarizable Fluctuating Charges (FQ) force field (J. Chem. Theory Comput. 2024, 20, 9954-9967) is here extended to the…

Chemical Physics · Physics 2025-11-14 Francesco Mazza , Marco Trinari , Chiara Sepali , Chiara Cappelli

Before a car-following model can be applied in practice, it must first be validated against real data in a process known as calibration. This paper discusses the formulation of calibration as an optimization problem, and compares different…

Systems and Control · Electrical Eng. & Systems 2024-12-20 Ronan Keane , H. Oliver Gao

In this paper, we discuss the convergence of an Algebraic MultiGrid (AMG) method for general symmetric positive-definite matrices. The method relies on an aggregation algorithm, named \emph{coarsening based on compatible weighted matching},…

Numerical Analysis · Mathematics 2023-07-18 Pasqua D'Ambra , Fabio Durastante , Salvatore Filippone , Ludmil Zikatanov

The state-of-the-art researches indicate that analytic algorithms are promising in handling complex floorplanning scenarios. However, it is challenging to generate compact floorplans with excellent wirelength optimization effect due to the…

Machine Learning · Computer Science 2025-09-29 Xinyan Meng , Huabin Cheng , Rujie Chen , Ning Xu , Yu Chen , Wei Zhang

This paper proposes a conjugate-gradient-based Adam algorithm blending Adam with nonlinear conjugate gradient methods and shows its convergence analysis. Numerical experiments on text classification and image classification show that the…

Optimization and Control · Mathematics 2020-03-04 Yu Kobayashi , Hideaki Iiduka

The conjugate gradient method (CG) is typically used with a preconditioner which improves efficiency and robustness of the method. Many preconditioners include parameters and a proper choice of a preconditioner and its parameters is often…

Numerical Analysis · Mathematics 2019-06-04 Alexandr Katrutsa , Mike Botchev , George Ovchinnikov , Ivan Oseledets

The use of mathematical models to make predictions about tumor growth and response to treatment has become increasingly more prevalent in the clinical setting. The level of complexity within these models ranges broadly, and the calibration…

Quantitative Methods · Quantitative Biology 2021-12-28 Allison L. Lewis , Kathleen M. Storey , Heyrim Cho , Anna C. Zittle

The certified descent algorithm (CDA) is a gradient-based method for shape optimization which certifies that the direction computed using the shape gradient is a genuine descent direction for the objective functional under analysis. It…

Numerical Analysis · Mathematics 2018-05-28 Matteo Giacomini

We propose a gradient-based method for quadratic programming problems with a single linear constraint and bounds on the variables. Inspired by the GPCG algorithm for bound-constrained convex quadratic programming [J.J. Mor\'e and G.…

Optimization and Control · Mathematics 2019-02-19 Daniela di Serafino , Gerardo Toraldo , Marco Viola , Jesse Barlow

High-through computational thermodynamic approaches are becoming an increasingly popular tool to uncover novel compounds. However, traditional methods tend to be limited to stability predictions of stoichiometric phases at absolute zero.…

Materials Science · Physics 2022-04-20 Sayan Samanta , Axel Van de Walle

We aim to investigate relationships between select processing parameters or inputs (composition, temperature, annealing time) and two structural parameters, specifically, the mean radius and volume fraction of the Fe$_3$Si nanocrystals. To…

Materials Science · Physics 2018-09-05 Rajesh Jha , Nirupam Chakraborti , David Diercks , Aaron Stebner , Cristian V. Ciobanu

We introduce Gradient Agreement Filtering (GAF) to improve on gradient averaging in distributed deep learning optimization. Traditional distributed data-parallel stochastic gradient descent involves averaging gradients of microbatches to…

Machine Learning · Computer Science 2024-12-31 Francois Chaubard , Duncan Eddy , Mykel J. Kochenderfer

Computer models, aiming at simulating a complex real system, are often calibrated in the light of data to improve performance. Standard calibration methods assume that the optimal values of calibration parameters are invariant to the model…

Methodology · Statistics 2017-09-01 Georgios Karagiannis , Bledar A. Konomi , Guang Lin

A scaled conjugate gradient method that accelerates existing adaptive methods utilizing stochastic gradients is proposed for solving nonconvex optimization problems with deep neural networks. It is shown theoretically that, whether with…

Machine Learning · Computer Science 2024-12-17 Naoki Sato , Koshiro Izumi , Hideaki Iiduka