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Spatial transcriptomics data analysis integrates cellular transcriptional activity with spatial coordinates to identify spatial domains, infer cell-type dynamics, and characterize gene expression patterns within tissues. Despite recent…

Quantitative Methods · Quantitative Biology 2026-03-25 Sean Cottrell , Guo-Wei Wei , Longxiu Huang

In the process of product design and digital fabrication, the structural analysis of a designed prototype is a fundamental and essential step. However, such a step is usually invisible or inaccessible to designers at the early sketching…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Deng Yu , Chufeng Xiao , Manfred Lau , Hongbo Fu

Due to the limit of mesh density, the improvement of the spatial precision of numerical computation always leads to a decrease in computing efficiency. Aiming at this inability of numerical computation, we propose a novel method for…

Numerical Analysis · Mathematics 2021-04-05 Handing Xu , Zhenguo Nie , Qingfeng Xu , Xinjun Liu

Spiking neural networks (SNNs), inspired by the spiking behavior of biological neurons, offer a distinctive approach for capturing the complexities of temporal data. However, their potential for spatial modeling in multivariate time-series…

Machine Learning · Computer Science 2025-08-19 Bang Hu , Changze Lv , Mingjie Li , Yunpeng Liu , Xiaoqing Zheng , Fengzhe Zhang , Wei cao , Fan Zhang

Incorporating scientific knowledge into deep learning (DL) models for materials-based simulations can constrain the network's predictions to be within the boundaries of the material system. Altering loss functions or adding physics-based…

Materials Science · Physics 2024-05-24 Ashley Lenau , Dennis M. Dimiduk , Stephen R. Niezgoda

Fast prediction of suspension rheology is fundamental for optimizing process efficiency and performance in numerous industrial settings. However, traditional simulations are computationally demanding due to explicit evaluation of contact…

Soft Condensed Matter · Physics 2026-02-10 Armin Aminimajd , Joao Maia , Abhinendra Singh

Generating stable molecular conformations typically forces a tradeoff between the physical realism of energy-based relaxation and the sampling efficiency of data-driven generative models. While machine learning force fields (MLFFs) can…

In recent years, there has been a rapid development of spatio-temporal prediction techniques in response to the increasing demands of traffic management and travel planning. While advanced end-to-end models have achieved notable success in…

Machine Learning · Computer Science 2023-11-09 Zhonghang Li , Lianghao Xia , Yong Xu , Chao Huang

We introduce a data-driven framework for identifying material behavior from full-field kinematics and force measurements in generalized (micromorphic) continua. Unlike traditional approaches that rely on constitutive assumptions or…

Numerical Analysis · Mathematics 2025-12-18 Jacinto Ulloa , Laurent Stainier

In medical imaging, the diffusion models have shown great potential for synthetic image generation tasks. However, these approaches often lack the interpretable connections between the generated and real images and can create anatomically…

Image and Video Processing · Electrical Eng. & Systems 2026-02-12 Jian-Qing Zheng , Yuanhan Mo , Yang Sun , Jiahua Li , Fuping Wu , Ziyang Wang , Tonia Vincent , Bartłomiej W. Papież

The development of a reliable subgrid-scale (SGS) model for large-eddy simulation (LES) is of great importance for many scientific and engineering applications. Recently, deep learning approaches have been tested for this purpose using…

Fluid Dynamics · Physics 2022-11-09 Junhyuk Kim , Hyojin Kim , Jiyeon Kim , Changhoon Lee

This paper presents a novel physics-informed diffusion model for generating synthetic net load data, addressing the challenges of data scarcity and privacy concerns. The proposed framework embeds physical models within denoising networks,…

Machine Learning · Computer Science 2024-06-05 Shaorong Zhang , Yuanbin Cheng , Nanpeng Yu

Spatiotemporal dynamics models are fundamental for various domains, from heat propagation in materials to oceanic and atmospheric flows. However, currently available neural network-based spatiotemporal modeling approaches fall short when…

Machine Learning · Computer Science 2025-02-11 Valerii Iakovlev , Harri Lähdesmäki

This paper explores the application of Stochastic Differential Equations (SDE) to interpret the text generation process of Large Language Models (LLMs) such as GPT-4. Text generation in LLMs is modeled as a stochastic process where each…

Machine Learning · Computer Science 2024-08-23 Yukun Zhang

Although an increased availability of computational resources has enabled high-fidelity simulations of turbulent flows, the RANS models are still the dominant tools for industrial applications. However, the predictive capabilities of RANS…

Fluid Dynamics · Physics 2018-11-19 Jian-Xun Wang , Jinlong Wu , Julia Ling , Gianluca Iaccarino , Heng Xiao

A simple micromechanical model of polycrystalline materials is proposed, which enables us to swiftly produce grain-boundary-stress distributions induced by the uniform external loading (in the elastic strain regime). Such statistical…

Materials Science · Physics 2024-05-24 Timon Mede , Samir El Shawish

Structural components are typically exposed to dynamic loading, such as earthquakes, wind, and explosions. Structural engineers should be able to conduct real-time analysis in the aftermath or during extreme disaster events requiring…

State-space models (SSMs) are a highly expressive model class for learning patterns in time series data and for system identification. Deterministic versions of SSMs (e.g. LSTMs) proved extremely successful in modeling complex time series…

Data driven generative machine learning models have recently emerged as one of the most promising approaches for new materials discovery. While the generator models can generate millions of candidates, it is critical to train fast and…

Materials Science · Physics 2021-12-14 Daniel Gleaves , Edirisuriya M. Dilanga Siriwardane , Yong Zhao , Nihang Fu , Jianjun Hu

Turbulence modeling is a critical component in numerical simulations of industrial flows based on Reynolds-averaged Navier-Stokes (RANS) equations. However, after decades of efforts in the turbulence modeling community, universally…

Fluid Dynamics · Physics 2017-03-22 Jian-Xun Wang , Jin-Long Wu , Heng Xiao
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