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Clinical use of finite element analysis requires validation and reproducibility studies. The current study compared two models of vertebral bodies including endplates, on the same experimental dataset and evaluated the influence of the…

Numerical Analysis · Mathematics 2024-02-15 V. Allard , C. Heidsieck , F. Bermond , C. Confavreux , C. Travert , L. Gajny , 3 , W. Skalli , D. Mitton , H. Follet

Background - Pulmonary insufficiency is a consequence of transannular patch repair in Tetralogy of Fallot (ToF), leading to late morbidity and mortality. Transcatheter native outflow tract pulmonary valve replacement (TPVR) has become…

The impact of increased stiffness and pulsatile load on the circulation and their influence on heart performance have been documented not only for cardiovascular events but also for ventricular dysfunctions. For this reason, computer models…

Numerical Analysis · Mathematics 2021-11-11 Federica Caforio , Christoph M. Augustin , Jordi Alastruey , Matthias A. F. Gsell , Gernot Plank

Capsular contracture is a pathological response to implant-based reconstructive breast surgery, where the ``capsule'' (tissue surrounding an implant) painfully thickens, contracts and deforms. It is known to affect breast-cancer survivors…

Cell Behavior · Quantitative Biology 2024-11-19 Yuqi Xiao , Leah Edelstein-Keshet , Alain Goriely , Kathryn V Issac

Quantitative assessment of cardiac left ventricle (LV) morphology is essential to assess cardiac function and improve the diagnosis of different cardiovascular diseases. In current clinical practice, LV quantification depends on the…

Image and Video Processing · Electrical Eng. & Systems 2020-12-25 Sulaiman Vesal , Mingxuan Gu , Andreas Maier , Nishant Ravikumar

We propose a Bayesian nonparametric utility-based group sequential design for a randomized clinical trial to compare a gel sealant to standard care for resolving air leaks after pulmonary resection. Clinically, resolving air leaks in the…

Applications · Statistics 2017-02-28 Yanxun Xu , Peter F. Thall , Peter Mueller , Mehran J. Reza

Background In vivo mechanical behaviour of the abdominal wall has been poorly characterised and important details are missing regarding the occurrence and post-operative recurrence rate of hernias which can be as high as 30 %. This study…

The aim of this study was to compare vastus lateralis (VL) and rectus femoris (RF) muscles for their nervous and mechanical adaptations during two bouts of downhill walking (DW) with load carriage performed two weeks apart. Moreover, we…

Understanding the formation, propagation, and breakdown of the main vortex ring (VR) is essential for characterizing left ventricular (LV) hemodynamics, as its dynamics have been linked to the onset and progression of cardiovascular…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Michael Neidlin , Jesus Garicano-Mena , Soledad Le Clainche

Mechanical ventilation is a key form of life support for patients with pulmonary impairment. Healthcare workers are required to continuously adjust ventilator settings for each patient, a challenging and time consuming task. Hence, it would…

Machine Learning · Computer Science 2022-10-07 Flemming Kondrup , Thomas Jiralerspong , Elaine Lau , Nathan de Lara , Jacob Shkrob , My Duc Tran , Doina Precup , Sumana Basu

We present a pulmonary vessel segmentation algorithm, which is fast, fully automatic and robust. It uses a coarse segmentation of the airway tree and a left and right lung labeled volume to restrict a vessel enhancement filter, based on an…

Computer Vision and Pattern Recognition · Computer Science 2013-04-29 M. Helmberger , M. Urschler , M. Pienn , Z. Balint , A. Olschewski , H. Bischof

There are more than 300,000 heart valves implanted annually worldwide with about 50% of them being mechanical valves. The heart valve replacement is often a common treatment for severe valvular disease. However, valves may dysfunction…

Fluid Dynamics · Physics 2018-03-12 Fardin Khalili , Peshala T. Gamage , Hansen Mansy

Background: The most widely used approach to joint modelling of repeated measurement and time to event data is to combine a linear Gaussian random effects model for the repeated measurements with a log-Gaussian frailty model for the…

Methodology · Statistics 2016-09-12 Elisabeth Waldmann , David Taylor-Robinson

Model-based reinforcement learning (RL) is more sample efficient than model-free RL by using imaginary trajectories generated by the learned dynamics model. When the model is inaccurate or biased, imaginary trajectories may be deleterious…

Machine Learning · Computer Science 2021-04-12 Wenzhen Huang , Qiyue Yin , Junge Zhang , Kaiqi Huang

Powerful large language models (LLMs) are increasingly expected to be deployed with lower computational costs, enabling their capabilities on resource-constrained devices. Post-training quantization (PTQ) has emerged as a star approach to…

Machine Learning · Computer Science 2025-02-20 Yuzhuang Xu , Shiyu Ji , Qingfu Zhu , Wanxiang Che

Accelerometry has been extensively studied as an objective means of measuring upper limb function in patients post-stroke. The objective of this paper is to determine whether the accelerometry-derived measurements frequently used in more…

Machine Learning · Computer Science 2023-11-09 Mackenzie Wallich , Kenneth Lai , Svetlana Yanushkevich

Anatomical and biophysical modeling of left atrium (LA) and proximal pulmonary veins (PPVs) is important for clinical management of several cardiac diseases. Magnetic resonance imaging (MRI) allows qualitative assessment of LA and PPVs…

Computer Vision and Pattern Recognition · Computer Science 2017-05-23 Aliasghar Mortazi , Rashed Karim , Kawal Rhode , Jeremy Burt , Ulas Bagci

The purpose of research was to check up the influence of decrease of nonequality of ventilating (after bronchodilator (berotec) inhalation (BI)) on the magnitude of dynamic compliance of lungs (Cdyn) at asthma patients with ventilating…

Tissues and Organs · Quantitative Biology 2007-05-23 Konstantin F. Tetenev

Reinforcement learning (RL)-based fine-tuning has become a crucial step in post-training language models for advanced mathematical reasoning and coding. Following the success of frontier reasoning models, recent work has demonstrated that…

Machine Learning · Computer Science 2025-08-11 Rosie Zhao , Alexandru Meterez , Sham Kakade , Cengiz Pehlevan , Samy Jelassi , Eran Malach

Cardiac growth and remodeling (G&R) patterns change ventricular size, shape, and function both globally and locally. Biomechanical, neurohormonal, and genetic stimuli drive these patterns through changes in myocyte dimension and fibrosis.…

Tissues and Organs · Quantitative Biology 2023-05-04 Amadeus M. Gebauer , Martin R. Pfaller , Fabian A. Braeu , Christian J. Cyron , Wolfgang A. Wall