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Recent advances in Vision-Language Models (VLMs) in histopathology, such as CONCH and QuiltNet, have demonstrated impressive zero-shot classification capabilities across various tasks. However, their general-purpose design may lead to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Jingna Qiu , Nishanth Jain , Jonas Ammeling , Marc Aubreville , Katharina Breininger

The development of vision-language models (VLMs) for histo-pathology has shown promising new usages and zero-shot performances. However, current approaches, which decompose large slides into smaller patches, focus solely on inductive…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Maxime Zanella , Fereshteh Shakeri , Yunshi Huang , Houda Bahig , Ismail Ben Ayed

Pathological diagnosis is vital for determining disease characteristics, guiding treatment, and assessing prognosis, relying heavily on detailed, multi-scale analysis of high-resolution whole slide images (WSI). However, existing large…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Shengxuming Zhang , Weihan Li , Tianhong Gao , Jiacong Hu , Haoming Luo , Xiuming Zhang , Jing Zhang , Mingli Song , Zunlei Feng

Vision-language foundation models (VLMs) show promise for diverse imaging tasks but often underperform on medical benchmarks. Prior efforts to improve performance include model finetuning, which requires large domain-specific datasets and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Arnav Singhvi , Vasiliki Bikia , Asad Aali , Akshay Chaudhari , Roxana Daneshjou

Large Language Models (LLMs) have demonstrated promise in medical knowledge assessments, yet their practical utility in real-world clinical decision-making remains underexplored. In this study, we evaluated the performance of three…

Computation and Language · Computer Science 2025-12-30 Mengdi Chai , Ali R. Zomorrodi

The large-scale pre-trained vision language models (VLM) have shown remarkable domain transfer capability on natural images. However, it remains unknown whether this capability can also apply to the medical image domain. This paper…

Computer Vision and Pattern Recognition · Computer Science 2023-02-08 Ziyuan Qin , Huahui Yi , Qicheng Lao , Kang Li

Large language models (LLMs) have shown remarkable capabilities in Natural Language Processing (NLP), especially in domains where labeled data is scarce or expensive, such as clinical domain. However, to unlock the clinical knowledge hidden…

Computation and Language · Computer Science 2023-09-18 Sonish Sivarajkumar , Mark Kelley , Alyssa Samolyk-Mazzanti , Shyam Visweswaran , Yanshan Wang

Vision-language models (VLMs) have recently shown remarkable zero-shot performance in medical image understanding, yet their grounding ability, the extent to which textual concepts align with visual evidence, remains underexplored. In the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Haozhe Luo , Shelley Zixin Shu , Ziyu Zhou , Sebastian Otalora , Mauricio Reyes

Vision-language artificial intelligence models (VLMs) possess medical knowledge and can be employed in healthcare in numerous ways, including as image interpreters, virtual scribes, and general decision support systems. However, here, we…

Cryptography and Security · Computer Science 2025-03-20 Jan Clusmann , Dyke Ferber , Isabella C. Wiest , Carolin V. Schneider , Titus J. Brinker , Sebastian Foersch , Daniel Truhn , Jakob N. Kather

In this paper, we address the challenge of few-shot classification in histopathology whole slide images (WSIs) by utilizing foundational vision-language models (VLMs) and slide-level prompt learning. Given the gigapixel scale of WSIs,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Devavrat Tomar , Guillaume Vray , Dwarikanath Mahapatra , Sudipta Roy , Jean-Philippe Thiran , Behzad Bozorgtabar

Large Vision-Language Models (LVLMs) have achieved significant success in recent years, and they have been extended to the medical domain. Although demonstrating satisfactory performance on medical Visual Question Answering (VQA) tasks,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Danfeng Guo , Demetri Terzopoulos

Vision-language models (VLMs) exhibit strong zero-shot generalization on natural images and show early promise in interpretable medical image analysis. However, existing benchmarks do not systematically evaluate whether these models truly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Tianhong Zhou , Yin Xu , Yingtao Zhu , Chuxi Xiao , Haiyang Bian , Lei Wei , Xuegong Zhang

Recent advancements in computational pathology have produced patch-level Multi-modal Large Language Models (MLLMs), but these models are limited by their inability to analyze whole slide images (WSIs) comprehensively and their tendency to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-13 Yuci Liang , Xinheng Lyu , Wenting Chen , Meidan Ding , Jipeng Zhang , Xiangjian He , Song Wu , Xiaohan Xing , Sen Yang , Xiyue Wang , Linlin Shen

Vision-Language Models (VLMs) have rapidly advanced alongside Large Language Models (LLMs). This study evaluates the capabilities of prominent generative VLMs, such as GPT-4.1 and Gemini 2.5 Pro, accessed via APIs, for histopathology image…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Samarth Singhal , Sandeep Singhal

This comprehensive review delves into the pivotal role of prompt engineering in unleashing the capabilities of Large Language Models (LLMs). The development of Artificial Intelligence (AI), from its inception in the 1950s to the emergence…

Computation and Language · Computer Science 2025-06-18 Banghao Chen , Zhaofeng Zhang , Nicolas Langrené , Shengxin Zhu

Recently, large language models (LLMs) have taken the spotlight in natural language processing. Further, integrating LLMs with vision enables the users to explore emergent abilities with multimodal data. Visual language models (VLMs), such…

Computer Vision and Pattern Recognition · Computer Science 2024-02-23 Minh-Hao Van , Prateek Verma , Xintao Wu

Generalist vision language models (VLMs) have made significant strides in computer vision, but they fall short in specialized fields like healthcare, where expert knowledge is essential. In traditional computer vision tasks, creative or…

OpenAI's latest large vision-language model (LVLM), GPT-4V(ision), has piqued considerable interest for its potential in medical applications. Despite its promise, recent studies and internal reviews highlight its underperformance in…

Computation and Language · Computer Science 2023-12-13 Pengcheng Chen , Ziyan Huang , Zhongying Deng , Tianbin Li , Yanzhou Su , Haoyu Wang , Jin Ye , Yu Qiao , Junjun He

Vision-language models (VLMs) can couple visual perception with open-ended clinical reasoning, making them attractive for computational histopathology. However, fine-tuning billions of parameters on scarce, expert-annotated pathology data…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Franciskus Xaverius Erick , Johanna Paula Müller , Bernhard Kainz

Vision-Language Models (VLMs) with their multimodal capabilities have demonstrated remarkable success in almost all domains, including education, transportation, healthcare, energy, finance, law, and retail. Nevertheless, the utilization of…

Machine Learning · Computer Science 2026-03-05 Betul Yurdem , Ferhat Ozgur Catak , Murat Kuzlu , Mehmet Kemal Gullu
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