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Large language models (LLMs) show promise for clinical use. They are often evaluated using datasets such as MedQA. However, Many medical datasets, such as MedQA, rely on simplified Question-Answering (Q\A) that underrepresents real-world…

Computation and Language · Computer Science 2025-10-24 Yunpeng Xiao , Carl Yang , Mark Mai , Xiao Hu , Kai Shu

There is a significant gap between patient needs and available mental health support today. In this paper, we aim to thoroughly examine the potential of using Large Language Models (LLMs) to assist professional psychotherapy. To this end,…

Computation and Language · Computer Science 2025-01-28 Mian Zhang , Xianjun Yang , Xinlu Zhang , Travis Labrum , Jamie C. Chiu , Shaun M. Eack , Fei Fang , William Yang Wang , Zhiyu Zoey Chen

We introduce SimulBench, a benchmark designed to evaluate large language models (LLMs) across a diverse collection of creative simulation scenarios, such as acting as a Linux terminal or playing text games with users. While these simulation…

Computation and Language · Computer Science 2024-09-13 Qi Jia , Xiang Yue , Tianyu Zheng , Jie Huang , Bill Yuchen Lin

User simulation has long played a vital role in computer science due to its potential to support a wide range of applications. Language, as the primary medium of human communication, forms the foundation of social interaction and behavior.…

While Large Language Models (LLMs) excel on standardized medical exams, high scores often fail to translate to high-quality responses for real-world medical queries. Current evaluations rely heavily on multiple-choice questions, failing to…

The discovery of novel small molecule drugs remains a critical scientific challenge with far-reaching implications for treating diseases and advancing human health. Traditional drug development--especially for small molecule…

Biomolecules · Quantitative Biology 2025-04-01 Bowen Gao , Yanwen Huang , Yiqiao Liu , Wenxuan Xie , Wei-Ying Ma , Ya-Qin Zhang , Yanyan Lan

Creating and deploying customized applications is crucial for operational success and enriching user experiences in the rapidly evolving modern business world. A prominent facet of modern user experiences is the integration of chatbots or…

The widespread availability of large language models (LLMs), such as ChatGPT, has significantly impacted education, raising both opportunities and challenges. Students can frequently interact with LLM-powered, interactive learning tools,…

Artificial Intelligence · Computer Science 2026-03-06 Hunter McNichols , Fareya Ikram , Andrew Lan

Recent advancements in Large Language Models (LLMs) have significantly enhanced conversational agents, making them applicable to various fields (e.g., education, entertainment). Despite their progress, the evaluation of the agents often…

Computation and Language · Computer Science 2025-09-29 Jiho Kim , Woosog Chay , Hyeonji Hwang , Daeun Kyung , Hyunseung Chung , Eunbyeol Cho , Yeonsu Kwon , Yohan Jo , Edward Choi

Chatbot-based customer support services have significantly advanced with the introduction of large language models (LLMs), enabling enhanced response quality and broader application across industries. However, while these advancements focus…

Human-Computer Interaction · Computer Science 2024-12-18 Sehyeong Jo , Jungwon Seo

Cancer clinical trials often face challenges in recruitment and engagement due to a lack of participant-facing informational and educational resources. This study investigated the potential of Large Language Models (LLMs), specifically…

Large language models (LLMs) are revolutionizing education, with LLM-based agents playing a key role in simulating student behavior. A major challenge in student simulation is modeling the diverse learning patterns of students at various…

Machine Learning · Computer Science 2025-08-12 Tao Wu , Jingyuan Chen , Wang Lin , Mengze Li , Yumeng Zhu , Ang Li , Kun Kuang , Fei Wu

Numerous medical systems powered by Large Language Models (LLMs) have achieved remarkable progress in diverse healthcare tasks. However, research on their medication safety remains limited due to the lack of real world datasets, constrained…

Artificial Intelligence · Computer Science 2025-11-07 Jiahao Zhao , Luxin Xu , Minghuan Tan , Lichao Zhang , Ahmadreza Argha , Hamid Alinejad-Rokny , Min Yang

Artificial Intelligence (AI) has been advancing rapidly and with the advent of large language models (LLMs) in late 2022, numerous opportunities have emerged for adopting this technology across various domains, including medicine. These…

Computers and Society · Computer Science 2026-03-10 Amr Alshatnawi , Remi Sampaleanu , David Liebovitz

Virtual Labs offer valuable opportunities for hands-on, inquiry-based science learning, yet teachers often struggle to adapt them to fit their instructional goals. Third-party materials may not align with classroom needs, and developing…

Computation and Language · Computer Science 2025-10-09 R. Alexander Knipper , Indrani Dey , Souvika Sarkar , Hari Narayanan , Sadhana Puntambekar , Santu Karmaker

The integration of Large Language Models (LLMs) into the healthcare domain has the potential to significantly enhance patient care and support through the development of empathetic, patient-facing chatbots. This study investigates an…

Computation and Language · Computer Science 2024-05-28 Man Luo , Christopher J. Warren , Lu Cheng , Haidar M. Abdul-Muhsin , Imon Banerjee

While Large Language Models (LLMs) achieve near-human performance on standard benchmarks, their capabilities often fail to generalize to complex, real-world problems. To bridge this gap, we introduce DeepQuestion, a scalable, automated…

Computation and Language · Computer Science 2026-03-02 Ali Khoramfar , Ali Ramezani , Mohammad Mahdi Mohajeri , Mohammad Javad Dousti , Majid Nili Ahmadabadi , Heshaam Faili

Therapeutic art activities, such as expressive drawing and painting, require the synergy between creative visual production and interactive dialogue. Recent advancements in Multimodal Large Language Models (MLLMs) have expanded the capacity…

Human-Computer Interaction · Computer Science 2026-05-12 Le Lin , Zihao Zhu , Rainbow Tin Hung Ho , Jing Liao , Yuhan Luo

The integration of large language models (LLMs) into virtual reality (VR) environments has opened new pathways for creating more immersive and interactive digital humans. By leveraging the generative capabilities of LLMs alongside…

Effective patient-provider communication is crucial in clinical care, directly impacting patient outcomes and quality of life. Traditional evaluation methods, such as human ratings, patient feedback, and provider self-assessments, are often…

Computation and Language · Computer Science 2024-09-25 Zhiyuan Wang , Fangxu Yuan , Virginia LeBaron , Tabor Flickinger , Laura E. Barnes