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Universal machine-learned potentials promise transferable accuracy across compositional and vibrational degrees of freedom, yet their application to biomolecular simulations remains underexplored. This work systematically evaluates…

Chemical Physics · Physics 2025-08-15 Viktor Zaverkin , Matheus Ferraz , Francesco Alesiani , Mathias Niepert

Experimental validation of chemical processes is slow and costly, limiting exploration in materials discovery. Machine learning can prioritize promising candidates, but existing data in patents and literature is heterogeneous and difficult…

Chemical Physics · Physics 2025-12-09 Mikhail Tsitsvero , Atsuyuki Nakao , Hisaki Ikebata

Foundation models for computational pathology are expected to facilitate the development of high-performing, generalisable deep learning systems. However, in addition to biologically relevant features, current foundation models also capture…

Abstract Interatomic potentials constitute the key component of large-scale atomistic simulations of materials. The recently proposed physically-informed neural network (PINN) method combines a high-dimensional regression implemented by an…

Computational Physics · Physics 2020-11-25 G. P. Purja Pun , V. Yamakov , J. Hickman , E. H. Glaessgen , Y. Mishin

The atomic-scale response of inhomogeneous fluids at interfaces and surrounding solute particles plays a critical role in governing chemical, electrochemical and biological processes at such interfaces. Classical molecular dynamics…

Materials Science · Physics 2023-11-28 Kamron Fazel , Nima Karimitari , Tanooj Shah , Christopher Sutton , Ravishankar Sundararaman

Accurate simulations of atomistic systems from first principles are limited by computational cost. In high-throughput settings, machine learning can reduce these costs significantly by accurately interpolating between reference…

Chemical Physics · Physics 2022-11-28 Haoyan Huo , Matthias Rupp

In this study, we present a highly configurable neuromorphic computing substrate and use it for emulating several types of neural networks. At the heart of this system lies a mixed-signal chip, with analog implementations of neurons and…

We introduce an end-to-end computational framework that allows for hyperparameter optimization using the DeepHyper library, accelerated model training, and interpretable AI inference. The framework is based on state-of-the-art AI models…

Materials Science · Physics 2023-08-16 Hyun Park , Ruijie Zhu , E. A. Huerta , Santanu Chaudhuri , Emad Tajkhorshid , Donny Cooper

Machine learning advances chemistry and materials science by enabling large-scale exploration of chemical space based on quantum chemical calculations. While these models supply fast and accurate predictions of atomistic chemical…

Chemical Physics · Physics 2019-06-25 K. T. Schütt , M. Gastegger , A. Tkatchenko , K. -R. Müller , R. J. Maurer

Physical implementations of neural computation now extend far beyond silicon hardware, encompassing substrates such as memristive devices, photonic circuits, mechanical metamaterials, microfluidic networks, chemical reaction systems, and…

Neural and Evolutionary Computing · Computer Science 2026-05-29 Stefan Fischer , Nihat Ay , Olaf Landsiedel , Esfandiar Mohammadi , Sebastian Otte , Bernd-Christian Renner , Nele Rußwinkel

The rapid emergence of universal Machine Learning Interatomic Potentials (uMLIPs) has transformed materials modeling. However, a comprehensive understanding of their generalization behavior across configurational space remains an open…

Materials Science · Physics 2025-12-30 Hossein Tahmasbi , Andreas Knüpfer , Thomas D. Kühne , Hossein Mirhosseini

One-dimensional nuclear magnetic resonance (NMR) spectroscopy is essential for molecular structure elucidation in organic synthesis, drug discovery, natural product characterization, and metabolomics, yet its interpretation remains heavily…

The length and time scales of atomistic simulations are limited by the computational cost of the methods used to predict material properties. In recent years there has been great progress in the use of machine learning algorithms to develop…

Computational Physics · Physics 2022-11-03 Alberto Hernandez , Adarsh Balasubramanian , Fenglin Yuan , Simon Mason , Tim Mueller

Binary metal clusters are of high interest for applications in heterogeneous catalysis and have received much attention in recent years. To gain insights into their structure and composition at the atomic scale, computer simulations can…

Chemical Physics · Physics 2020-04-10 Jan Weinreich , Anton Römer , Martín Leandro Paleico , Jörg Behler

Large-scale computer simulations of chemical atoms are used in a wide range of applications, including batteries, drugs, and more. However, there is a problem with efficiency as it takes a long time due to the large amount of calculation.…

Materials Science · Physics 2024-02-28 Hyun Gyu Park , Soohaeng Yoo Willow , D. ChangMo Yang , Chang Woo Myung

Amorphous materials exhibit unique properties that make them suitable for various applications in science and technology, ranging from optical and electronic devices and solid-state batteries to protective coatings. However, data-driven…

Materials Science · Physics 2024-02-02 Hui Zheng , Eric Sivonxay , Max Gallant , Ziyao Luo , Matthew McDermott , Patrick Huck , Kristin A. Persson

The capacity of an embodied agent to understand, predict, and interact with its environment is fundamentally contingent on an internal world model. This paper introduces a novel framework for investigating the formation and adaptation of…

Neural and Evolutionary Computing · Computer Science 2025-11-05 Brennen Hill

In studying solidification process by simulations on the atomic scale, the modeling of crystal nucleation or amorphisation requires the construction of interatomic interactions that are able to reproduce the properties of both the solid and…

We present the GPU version of DeePMD-kit, which, upon training a deep neural network model using ab initio data, can drive extremely large-scale molecular dynamics (MD) simulation with ab initio accuracy. Our tests show that the GPU version…

Computational Physics · Physics 2020-10-28 Denghui Lu , Han Wang , Mohan Chen , Jiduan Liu , Lin Lin , Roberto Car , Weinan E , Weile Jia , Linfeng Zhang

We introduce machine learning models of quantum mechanical observables of atoms in molecules. Instant out-of-sample predictions for proton and carbon nuclear chemical shifts, atomic core level excitations, and forces on atoms reach…

Chemical Physics · Physics 2015-08-26 Matthias Rupp , Raghunathan Ramakrishnan , O. Anatole von Lilienfeld