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Biological cells can actively tune their intracellular architecture according to their overall shape. Here we explore the rheological implication of such coupling in a minimal model of a dense cellular material where each cell exerts an…

Soft Condensed Matter · Physics 2022-04-13 Shao-Zhen Lin , Matthias Merkel , Jean-François Rupprecht

Bone is a stiff and though, hierarchical and continuously evolving material that optimizes its structure to respond to mechanical stimuli, which also govern growth and remodeling processes. However, a full understanding of the underlying…

Applied Physics · Physics 2022-06-30 M. Fraldi , A. Cutolo , A. R. Carotenuto , S. Palumbo , F. Bosia , N. M. Pugno

The question of what guides lineage segregation is central to development, where cellular differentiation leads to segregated cell populations destined for specialized functions. Here, using optical tweezers measurements of mouse embryonic…

We show by numerical simulations that discretized versions of commonly studied continuum nonlinear growth equations (such as the Kardar-Parisi-Zhang equation and the Lai-Das Sarma equation) and related atomistic models of epitaxial growth…

Condensed Matter · Physics 2009-10-28 C. Dasgupta , J. M. Kim , M. Dutta , S. Das Sarma

In order to improve the understanding of damage evolution in mechanically heterogeneous microstructures, like the ones of dual-phase steels, the influence of the applied stress state is a key element. In this work, we studied the influence…

Materials Science · Physics 2020-06-05 Carl F. Kusche , Felix Pütz , Sebastian Münstermann , Talal Al-Samman , Sandra Korte-Kerzel

Many morphogenetic processes involve mechanical rearrangement of epithelial tissues that is driven by precisely regulated cytoskeletal forces and cell adhesion. The mechanical state of the cell and intercellular adhesion are not only the…

Cell Behavior · Quantitative Biology 2015-06-03 Kevin K. Chiou , Lars Hufnagel , Boris I. Shraiman

Flexible electronic systems such as roll up displays, wearable devices etc. promise exciting possibilities that could change the way humans interact with the environment. However, they suffer from poor reliability of interconnects and…

Soft Condensed Matter · Physics 2019-02-06 Amit Kumar , Virendra Parab , Arindan Handu , Li Ding , Sanjiv Sambandan

The electron beam-plasma system is ubiquitous in the space plasma environment. Here, using a Darwin particle-in-cell method, the excitation of electrostatic and whistler instabilities by a gyrating electron beam is studied in support of…

Plasma Physics · Physics 2018-12-31 Xin An , Jacob Bortnik , Bart Van Compernolle , Viktor Decyk , Richard Thorne

Long-term simulations of energetic electron fluxes in many space plasma systems require accounting for two groups of processes with well separated time-scales: microphysics of electron resonant scattering by electromagnetic waves and…

Plasma Physics · Physics 2021-10-04 A. S. Lukin , A. V. Artemyev , A. A. Petrukovich

Incremental stiffness characterizes the variation of a material's force response to a small deformation change. Typically materials have an incremental stiffness that is fixed and positive, but recent technologies, such as super-lenses, low…

Materials Science · Physics 2016-01-20 Marc Serra-Garcia , Joseph Lydon , Chiara Daraio

Soft biological tissues exhibit a tendency to maintain a preferred state of tensile stress, known as tensional homeostasis, which is restored even after external mechanical stimuli. This macroscopic behavior can be described using the…

Machine Learning · Computer Science 2025-01-23 Hagen Holthusen , Tim Brepols , Kevin Linka , Ellen Kuhl

When stressed sufficiently, solid materials yield and deform plastically via reorganization of microscopic constituents. Indeed, it is possible to alter the micro-structure of materials by judicious application of stress, an empirical pro-…

Soft Condensed Matter · Physics 2021-08-09 K. L. Galloway , Xiaoguang Ma , Nathan C. Keim , Douglas J. Jerolmack , Arjun G. Yodh , Paulo E. Arratia

Dynamic fragmentation simulations are essential for predicting material response at high strain rates, yet explicit dynamic simulations that combine an extrinsic cohesive-zone model (CZM) with penalty-based contact often exhibit severe…

Computational Physics · Physics 2025-11-19 Thibault Ghesquière-Diérickx , Jean-François Molinari , Guillaume Anciaux

Understanding the evolution of structure and functionality through amorphous to crystalline phase transitions is critical for predicting and designing devices for application in extreme conditions. Here, we consider both aspects of…

Material renewability in active living systems, such as in cells and tissues, can drive the large-scale patterning of forces, with distinctive phenotypic consequences. This is especially significant in the cell cytoskeleton, where multiple…

Soft Condensed Matter · Physics 2025-04-25 Ayan Roychowdhury , Saptarshi Dasgupta , Madan Rao

Pull-in (or electro-mechanical) instability occurs when a drastic decrease in the thickness of a dielectric elastomer results in electrical breakdown, which limits the applications of dielectric devices. Here we derive the criteria for…

Soft Condensed Matter · Physics 2020-09-04 Yipin Su , Weiqiu Chen , Michel Destrade

We present theoretical and experimental studies of the elastic response of fibrous networks subjected to uniaxial strain. Uniaxial compression or extension is applied to extracellular networks of fibrin and collagen using a shear rheometer…

The recent discovery of bone flexoelectricity (electrical polarization induced by strain gradient) suggests that flexoelectricity could have physiological effects in bones, and specifically near bone fractures, where flexoelectricity is…

Tissues and Organs · Quantitative Biology 2020-01-27 Raquel Núñez-Toldrà , Fabian Vasquez-Sancho , Nathalie Barroca , Gustau Catalan

The rheological properties of biological tissues, though fundamental to many physiological and pathological processes such as embryonic development, wound healing, and tumor progression, remain poorly understood. A recent study showed that…

Soft Condensed Matter · Physics 2026-02-25 Tanmoy Ghosh , Kabir Ramola , Saroj Kumar Nandi

The importance of individual cells in a developing multicellular organism is well known but precisely how the individual cellular characteristics of those cells collectively drive the emergence of robust, homeostatic structures is less well…

Tissues and Organs · Quantitative Biology 2017-02-20 Philip Gerlee , David Basanta , Alexander R. A. Anderson
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