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The retina provides a unique, noninvasive window into Alzheimer's disease (AD) and dementia, capturing early structural changes through morphometric features, while systemic and lifestyle risk factors reflect well-established contributors…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Seowung Leem , Lin Gu , Chenyu You , Kuang Gong , Ruogu Fang

Alzheimer's disease is a progressive neurological disorder characterized by cognitive impairment and memory loss. With the increasing aging population, the incidence of AD is continuously rising, making early diagnosis and intervention an…

Image and Video Processing · Electrical Eng. & Systems 2023-11-23 Guian Fang , Mengsha Liu , Yi Zhong , Zhuolin Zhang , Jiehui Huang , Zhenchao Tang , Calvin Yu-Chian Chen

Early diagnosis of Alzheimer's disease (AD) is critical for intervention before irreversible neurodegeneration occurs. Structural MRI (sMRI) is widely used for AD diagnosis, but conventional deep learning approaches primarily rely on…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Shijia Zhang , Xiyu Ding , Brian Caffo , Junyu Chen , Cindy Zhang , Hadi Kharrazi , Zheyu Wang

Large vessel occlusion (LVO) plays an important role in the diagnosis of acute ischemic stroke. Identifying LVO of patients in the early stage on admission would significantly lower the probabilities of suffering from severe effects due to…

Image and Video Processing · Electrical Eng. & Systems 2019-06-20 Jia You , Philip L. H. Yu , Anderson C. O. Tsang , Eva L. H. Tsui , Pauline P. S. Woo , Gilberto K. K. Leung

The cerebrospinal fluid (CSF) of 19 subjects who received a clinical diagnosis of Alzheimer's disease (AD) as well as of 5 pathological controls have been collected and analysed by Raman spectroscopy (RS). We investigated whether the raw…

INTRODUCTION: Alzheimer's disease (AD) is genetically complex, complicating robust classification from genomic data. METHODS: We developed a transformer-based ensemble model (TrUE-Net) using Monte Carlo Dropout for uncertainty estimation in…

Genomics · Quantitative Biology 2025-06-03 Taeho Jo , Eun Hye Lee , Alzheimer's Disease Sequencing Project

Early detection of clinical outcomes such as cancer may be predicted based on longitudinal biomarker measurements. Tracking longitudinal biomarkers as a way to identify early disease onset may help to reduce mortality from diseases like…

Automatic identification and categorization of Alzheimer's patients and the ability to distinguish between different levels of this disease can be very helpful to the research community in this field, since other non-automatic approaches…

Signal Processing · Electrical Eng. & Systems 2019-04-17 Esmaeil Seraj , Mehran Yazdi , Nastaran Shahparian

Early diagnosis of Alzheimer's disease is a challenge because the existing methodologies do not identify the patients in their preclinical stage, which can last up to a decade prior to the onset of clinical symptoms. Several research…

Machine Learning · Computer Science 2024-01-03 Vivek Kumar Tiwari , Premananda Indic , Shawana Tabassum

Alzheimer's disease (AD) is an irreversible neurode generative disease of the brain.The disease may causes memory loss, difficulty communicating and disorientation. For the diagnosis of Alzheimer's disease, a series of scales are often…

Image and Video Processing · Electrical Eng. & Systems 2022-01-13 Yelu Gao , Huang Huang , Lian Zhang

Increasing effort in brain image analysis has been dedicated to early diagnosis of Alzheimer's disease (AD) based on neuroimaging data. Most existing studies have been focusing on binary classification problems, e.g., distinguishing AD…

Computer Vision and Pattern Recognition · Computer Science 2017-09-14 Hongming Li , Mohamad Habes , Yong Fan

Accurate segmentation of retinal images plays a crucial role in aiding ophthalmologists in diagnosing retinopathy of prematurity (ROP) and assessing its severity. However, due to their underdeveloped, thinner vessels, manual annotation in…

Computer Vision and Pattern Recognition · Computer Science 2024-11-15 Gozde Merve Demirci , Jiachen Yao , Ming-Chih Ho , Xiaoling Hu , Wei-Chi Wu , Chao Chen , Chia-Ling Tsai

Alongside neuroimaging such as MRI scans and PET, Alzheimer's disease (AD) datasets contain valuable tabular data including AD biomarkers and clinical assessments. Existing computer vision approaches struggle to utilize this additional…

Computer Vision and Pattern Recognition · Computer Science 2023-08-30 Weichen Huang

Alzheimer's disease (AD) is the most common long-term illness in elderly people. In recent years, deep learning has become popular in the area of medical imaging and has had a lot of success there. It has become the most effective way to…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Mahin Khan Mahadi , Abdullah Abdullah , Jamal Uddin , Asif Newaz

In the complex realm of cognitive disorders, Alzheimer's disease (AD) and vascular dementia (VaD) are the two most prevalent dementia types, presenting entangled symptoms yet requiring distinct treatment approaches. The crux of effective…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Salma Hassan , Dawlat Akaila , Maryam Arjemandi , Vijay Papineni , Mohammad Yaqub

Deep learning has great potential for accurate detection and classification of diseases with medical imaging data, but the performance is often limited by the number of training datasets and memory requirements. In addition, many deep…

Image and Video Processing · Electrical Eng. & Systems 2021-01-14 Xiaofeng Liu , Fangxu Xing , Chao Yang , C. -C. Jay Kuo , Suma Babu , Georges El Fakhri , Thomas Jenkins , Jonghye Woo

The ROC curve is the gold standard for measuring the performance of a test/scoring statistic regarding its capacity to discriminate between two statistical populations in a wide variety of applications, ranging from anomaly detection in…

Statistics Theory · Mathematics 2023-01-25 Stéphan Clémençon , Myrto Limnios , Nicolas Vayatis

The transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is of great interest to clinical researchers. This phenomenon also serves as a valuable data source for quantitative methodological researchers developing new…

Applications · Statistics 2020-12-02 Zihuan Liu , Tapabrate Maiti , Andrew R. Bender

We present the findings of "The Alzheimer's Disease Prediction Of Longitudinal Evolution" (TADPOLE) Challenge, which compared the performance of 92 algorithms from 33 international teams at predicting the future trajectory of 219…

Populations and Evolution · Quantitative Biology 2021-12-30 Razvan V. Marinescu , Neil P. Oxtoby , Alexandra L. Young , Esther E. Bron , Arthur W. Toga , Michael W. Weiner , Frederik Barkhof , Nick C. Fox , Arman Eshaghi , Tina Toni , Marcin Salaterski , Veronika Lunina , Manon Ansart , Stanley Durrleman , Pascal Lu , Samuel Iddi , Dan Li , Wesley K. Thompson , Michael C. Donohue , Aviv Nahon , Yarden Levy , Dan Halbersberg , Mariya Cohen , Huiling Liao , Tengfei Li , Kaixian Yu , Hongtu Zhu , Jose G. Tamez-Pena , Aya Ismail , Timothy Wood , Hector Corrada Bravo , Minh Nguyen , Nanbo Sun , Jiashi Feng , B. T. Thomas Yeo , Gang Chen , Ke Qi , Shiyang Chen , Deqiang Qiu , Ionut Buciuman , Alex Kelner , Raluca Pop , Denisa Rimocea , Mostafa M. Ghazi , Mads Nielsen , Sebastien Ourselin , Lauge Sorensen , Vikram Venkatraghavan , Keli Liu , Christina Rabe , Paul Manser , Steven M. Hill , James Howlett , Zhiyue Huang , Steven Kiddle , Sach Mukherjee , Anais Rouanet , Bernd Taschler , Brian D. M. Tom , Simon R. White , Noel Faux , Suman Sedai , Javier de Velasco Oriol , Edgar E. V. Clemente , Karol Estrada , Leon Aksman , Andre Altmann , Cynthia M. Stonnington , Yalin Wang , Jianfeng Wu , Vivek Devadas , Clementine Fourrier , Lars Lau Raket , Aristeidis Sotiras , Guray Erus , Jimit Doshi , Christos Davatzikos , Jacob Vogel , Andrew Doyle , Angela Tam , Alex Diaz-Papkovich , Emmanuel Jammeh , Igor Koval , Paul Moore , Terry J. Lyons , John Gallacher , Jussi Tohka , Robert Ciszek , Bruno Jedynak , Kruti Pandya , Murat Bilgel , William Engels , Joseph Cole , Polina Golland , Stefan Klein , Daniel C. Alexander

Deep learning is attracting significant interest in the neuroimaging community as a means to diagnose psychiatric and neurological disorders from structural magnetic resonance images. However, there is a tendency amongst researchers to…

Machine Learning · Computer Science 2019-10-22 David Wood , James Cole , Thomas Booth