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Deep learning has proven to yield fast and accurate predictions of quantum-chemical properties to accelerate the discovery of novel molecules and materials. As an exhaustive exploration of the vast chemical space is still infeasible, we…

Machine Learning · Statistics 2020-01-10 Niklas W. A. Gebauer , Michael Gastegger , Kristof T. Schütt

Machine learning in drug discovery has been focused on virtual screening of molecular libraries using discriminative models. Generative models are an entirely different approach that learn to represent and optimize molecules in a continuous…

Quantitative Methods · Quantitative Biology 2020-11-17 Matthew Ragoza , Tomohide Masuda , David Ryan Koes

Generative models aim to learn the probability distributions underlying data, enabling the generation of new, realistic samples. Quantum inspired generative models, such as Born machines based on the matrix product state framework, have…

Machine Learning · Computer Science 2025-12-30 Wanda Hou , Miao Li , Yi-Zhuang You

Generative adversarial networks (GANs) have emerged as a powerful tool for generating high-fidelity data. However, the main bottleneck of existing approaches is the lack of supervision on the generator training, which often results in…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Baoren Xiao , Hao Ni , Weixin Yang

Many existing conditional Generative Adversarial Networks (cGANs) are limited to conditioning on pre-defined and fixed class-level semantic labels or attributes. We propose an open set GAN architecture (OpenGAN) that is conditioned…

Computer Vision and Pattern Recognition · Computer Science 2020-03-19 Luke Ditria , Benjamin J. Meyer , Tom Drummond

While generative models have recently become ubiquitous in many scientific areas, less attention has been paid to their evaluation. For molecular generative models, the state-of-the-art examines their output in isolation or in relation to…

Generative adversarial networks (GANs) are a powerful framework for generative tasks. However, they are difficult to train and tend to miss modes of the true data generation process. Although GANs can learn a rich representation of the…

Machine Learning · Computer Science 2017-11-27 Robin Winter , Djork-Arné Clevert

Generating as diverse molecules as possible with desired properties is crucial for drug discovery research, which invokes many approaches based on deep generative models today. Despite recent advancements in these models, particularly in…

Machine Learning · Computer Science 2024-07-17 Changhun Lee , Gyumin Lee

We apply generative adversarial network (GAN) technology to build an event generator that simulates particle production in electron-proton scattering that is free of theoretical assumptions about underlying particle dynamics. The difficulty…

Biomarker discovery is vital in advancing personalized medicine, offering insights into disease diagnosis, prognosis, and therapeutic efficacy. Traditionally, the identification and validation of biomarkers heavily depend on extensive…

Machine Learning · Computer Science 2024-09-25 Wangyang Ying , Dongjie Wang , Xuanming Hu , Ji Qiu , Jin Park , Yanjie Fu

Soft sensing infers hard-to-measure data through a large number of easily obtainable variables. However, in complex industrial scenarios, the issue of insufficient data volume persists, which diminishes the reliability of soft sensing.…

Machine Learning · Computer Science 2025-12-23 Zesen Wang , Yonggang Li , Lijuan Lan

Generative Adversarial Networks (GANs) represent a promising class of generative networks that combine neural networks with game theory. From generating realistic images and videos to assisting musical creation, GANs are transforming many…

Machine Learning · Computer Science 2017-12-04 Alexandre Yahi , Rami Vanguri , Noémie Elhadad , Nicholas P. Tatonetti

Generative Adversarial Networks (GANs) have gained a lot of attention from machine learning community due to their ability to learn and mimic an input data distribution. GANs consist of a discriminator and a generator working in tandem…

Computation and Language · Computer Science 2018-06-19 Saurabh Sahu , Rahul Gupta , Carol Espy-Wilson

In this paper, we explore machine translation improvement via Generative Adversarial Network (GAN) architecture. We take inspiration from RelGAN, a model for text generation, and NMT-GAN, an adversarial machine translation model, to…

Computation and Language · Computer Science 2021-12-01 Jay Ahn , Hari Madhu , Viet Nguyen

One of the main motivations for training high quality image generative models is their potential use as tools for image manipulation. Recently, generative adversarial networks (GANs) have been able to generate images of remarkable quality.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-01 Aviv Gabbay , Yedid Hoshen

Recently, molecule generation using deep learning has been actively investigated in drug discovery. In this field, Transformer and VAE are widely used as powerful models, but they are rarely used in combination due to structural and…

Biomolecules · Quantitative Biology 2024-04-08 Yasuhiro Yoshikai , Tadahaya Mizuno , Shumpei Nemoto , Hiroyuki Kusuhara

Generative Adversarial Networks (GAN) are trained to generate sample images of interest distribution. To this end, generator network of GAN learns implicit distribution of real data set from the classification with candidate generated…

Machine Learning · Computer Science 2020-11-17 Gahye Lee , Seungkyu Lee

Self-supervised neural language models have recently found wide applications in generative design of organic molecules and protein sequences as well as representation learning for downstream structure classification and functional…

Materials Science · Physics 2022-09-21 Lai Wei , Nihang Fu , Yuqi Song , Qian Wang , Jianjun Hu

We propose to improve unconditional Generative Adversarial Networks (GAN) by training the self-supervised learning with the adversarial process. In particular, we apply self-supervised learning via the geometric transformation on input…

Computer Vision and Pattern Recognition · Computer Science 2019-05-15 Ngoc-Trung Tran , Viet-Hung Tran , Ngoc-Bao Nguyen , Ngai-Man Cheung

Generative adversarial networks (GANs)successfully generate high quality data by learning amapping from a latent vector to the data. Various studies assert that the latent space of a GAN is semanticallymeaningful and can be utilized for…

Computer Vision and Pattern Recognition · Computer Science 2020-03-06 Duhyeon Bang , Seoungyoon Kang , Hyunjung Shim