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Predicting clinical outcomes from preclinical data is essential for identifying safe and effective drug combinations, reducing late-stage clinical failures, and accelerating the development of precision therapies. Current AI models rely on…

Distributed representations of medical concepts have been used to support downstream clinical tasks recently. Electronic Health Records (EHR) capture different aspects of patients' hospital encounters and serve as a rich source for…

Computation and Language · Computer Science 2020-01-07 Shaika Chowdhury , Chenwei Zhang , Philip S. Yu , Yuan Luo

Multimodal electronic health record (EHR) data can offer a holistic assessment of a patient's health status, supporting various predictive healthcare tasks. Recently, several studies have embraced the multitask learning approach in the…

Machine Learning · Computer Science 2024-06-19 Muhao Xu , Zhenfeng Zhu , Youru Li , Shuai Zheng , Yawei Zhao , Kunlun He , Yao Zhao

With the increasing availability of diverse data types, particularly images and time series data from medical experiments, there is a growing demand for techniques designed to combine various modalities of data effectively. Our motivation…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Ali Rasekh , Reza Heidari , Amir Hosein Haji Mohammad Rezaie , Parsa Sharifi Sedeh , Zahra Ahmadi , Prasenjit Mitra , Wolfgang Nejdl

The polypharmacy side effect prediction problem considers cases in which two drugs taken individually do not result in a particular side effect; however, when the two drugs are taken in combination, the side effect manifests. In this work,…

Databases · Computer Science 2018-10-23 Brandon Malone , Alberto García-Durán , Mathias Niepert

The treatment effects of medications play a key role in guiding medical prescriptions. They are usually assessed with randomized controlled trials (RCTs), which are expensive. Recently, large-scale electronic health records (EHRs) have…

Machine Learning · Statistics 2019-08-20 Linying Zhang , Yixin Wang , Anna Ostropolets , Jami J. Mulgrave , David M. Blei , George Hripcsak

Medication recommendation is a crucial task for assisting physicians in making timely decisions from longitudinal patient medical records. However, real-world EHR data present significant challenges due to the presence of rarely observed…

Artificial Intelligence · Computer Science 2025-08-15 Yan Ting Chok , Soyon Park , Seungheun Baek , Hajung Kim , Junhyun Lee , Jaewoo Kang

Multi-modal knowledge graph completion (MMKGC) aims to predict the missing triples in the multi-modal knowledge graphs by incorporating structural, visual, and textual information of entities into the discriminant models. The information…

Artificial Intelligence · Computer Science 2024-02-26 Yichi Zhang , Zhuo Chen , Lei Liang , Huajun Chen , Wen Zhang

Context-aware recommendation systems improve upon classical recommender systems by including, in the modelling, a user's behaviour. Research into context-aware recommendation systems has previously only considered the sequential ordering of…

Information Retrieval · Computer Science 2022-10-20 Mufhumudzi Muthivhi , Terence L. van Zyl , Hairong Wang

Machine learning holds promise for advancing clinical decision support, yet it remains unclear when multimodal learning truly helps in practice, particularly under modality missingness and fairness constraints. In this work, we conduct a…

Machine Learning · Computer Science 2026-03-02 Kejing Yin , Haizhou Xu , Wenfang Yao , Chen Liu , Zijie Chen , Yui Haang Cheung , William K. Cheung , Jing Qin

Drug recommendation (DR) systems aim to support healthcare professionals in selecting appropriate medications based on patients' medical conditions. State-of-the-art approaches utilize deep learning techniques for improving DR, but fall…

Information Retrieval · Computer Science 2025-11-03 Yu Lin , Zhen Jia , Philipp Christmann , Xu Zhang , Shengdong Du , Tianrui Li

A well-designed recommender system can accurately capture the attributes of users and items, reflecting the unique preferences of individuals. Traditional recommendation techniques usually focus on modeling the singular type of behaviors…

Information Retrieval · Computer Science 2023-03-06 Hongrui Xuan , Yi Liu , Bohan Li , Hongzhi Yin

Combinatorial medication recommendation(CMR) is a fundamental task of healthcare, which offers opportunities for clinical physicians to provide more precise prescriptions for patients with intricate health conditions, particularly in the…

Artificial Intelligence · Computer Science 2025-01-14 Jie Tan , Yu Rong , Kangfei Zhao , Tian Bian , Tingyang Xu , Junzhou Huang , Hong Cheng , Helen Meng

Concept bottleneck models (CBMs), which predict human-interpretable concepts (e.g., nucleus shapes in cell images) before predicting the final output (e.g., cell type), provide insights into the decision-making processes of the model.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Winnie Pang , Xueyi Ke , Satoshi Tsutsui , Bihan Wen

Self-supervised representation learning for human action recognition has developed rapidly in recent years. Most of the existing works are based on skeleton data while using a multi-modality setup. These works overlooked the differences in…

Computer Vision and Pattern Recognition · Computer Science 2024-01-12 Yiping Wei , Kunyu Peng , Alina Roitberg , Jiaming Zhang , Junwei Zheng , Ruiping Liu , Yufan Chen , Kailun Yang , Rainer Stiefelhagen

Machine learning methods in healthcare have traditionally focused on using data from a single modality, limiting their ability to effectively replicate the clinical practice of integrating multiple sources of information for improved…

Machine Learning · Computer Science 2024-02-13 Felix Krones , Umar Marikkar , Guy Parsons , Adam Szmul , Adam Mahdi

Reliability of machine learning (ML) systems is crucial in safety-critical applications such as healthcare, and uncertainty estimation is a widely researched method to highlight the confidence of ML systems in deployment. Sequential and…

Machine Learning · Computer Science 2021-04-23 Utkarsh Sarawgi , Rishab Khincha , Wazeer Zulfikar , Satrajit Ghosh , Pattie Maes

Multi-modal entity alignment (MMEA) is essential for enhancing knowledge graphs and improving information retrieval and question-answering systems. Existing methods often focus on integrating modalities through their complementarity but…

Artificial Intelligence · Computer Science 2024-10-21 Wei Ai , Wen Deng , Hongyi Chen , Jiayi Du , Tao Meng , Yuntao Shou

Most of the existing medication recommendation models are predicted with only structured data such as medical codes, with the remaining other large amount of unstructured or semi-structured data underutilization. To increase the utilization…

Computation and Language · Computer Science 2024-07-16 Yu-Tzu Lee

Background: Medication review is a structured interview of the patient, performed by the pharmacist and aimed at optimizing drug treatments. In practice, medication review is a long and cognitively-demanding task that requires specific…