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This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Large language models (LLMs) exhibit strong generative capabilities but remain vulnerable to confabulations, fluent yet unreliable outputs that vary arbitrarily even under identical prompts. Leveraging a quantum tensor network based…

Computation and Language · Computer Science 2026-02-03 Pragatheeswaran Vipulanandan , Kamal Premaratne , Dilip Sarkar

The recent performance leap of Large Language Models (LLMs) opens up new opportunities across numerous industrial applications and domains. However, erroneous generations, such as false predictions, misinformation, and hallucination made by…

Software Engineering · Computer Science 2025-01-07 Yuheng Huang , Jiayang Song , Zhijie Wang , Shengming Zhao , Huaming Chen , Felix Juefei-Xu , Lei Ma

Large language models (LLMs) have shown remarkable achievements in natural language processing tasks, producing high-quality outputs. However, LLMs still exhibit limitations, including the generation of factually incorrect information. In…

Computation and Language · Computer Science 2023-11-17 Sridevi Wagle , Sai Munikoti , Anurag Acharya , Sara Smith , Sameera Horawalavithana

Modern Large Language Models (LLMs) often require external tools, such as machine learning classifiers or knowledge retrieval systems, to provide accurate answers in domains where their pre-trained knowledge is insufficient. This…

Machine Learning · Computer Science 2025-05-23 Panagiotis Lymperopoulos , Vasanth Sarathy

Large Language Models (LLMs) are prone to generating fluent but incorrect content, known as confabulation, which poses increasing risks in multi-turn or agentic applications where outputs may be reused as context. In this work, we…

Computation and Language · Computer Science 2026-03-18 Tianyi Zhou , Johanne Medina , Sanjay Chawla

As large language models (LLMs) continue to evolve, understanding and quantifying the uncertainty in their predictions is critical for enhancing application credibility. However, the existing literature relevant to LLM uncertainty…

Computation and Language · Computer Science 2024-10-22 Hsiu-Yuan Huang , Yutong Yang , Zhaoxi Zhang , Sanwoo Lee , Yunfang Wu

Despite the massive advancements in large language models (LLMs), they still suffer from producing plausible but incorrect responses. To improve the reliability of LLMs, recent research has focused on uncertainty quantification to predict…

Artificial Intelligence · Computer Science 2025-04-01 Yongjin Yang , Haneul Yoo , Hwaran Lee

Large language models (LLMs) are increasingly employed in information-seeking and decision-making tasks. Despite their broad utility, LLMs tend to generate information that conflicts with real-world facts, and their persuasive style can…

Computation and Language · Computer Science 2024-09-19 Arslan Chaudhry , Sridhar Thiagarajan , Dilan Gorur

Large language models (LLMs) produce outputs with varying levels of uncertainty, and, just as often, varying levels of correctness; making their practical reliability far from guaranteed. To quantify this uncertainty, we systematically…

Computation and Language · Computer Science 2025-10-24 Christian Hobelsberger , Theresa Winner , Andreas Nawroth , Oliver Mitevski , Anna-Carolina Haensch

Large language models (LLMs) have demonstrated remarkable capabilities across various tasks. However, these models could offer biased, hallucinated, or non-factual responses camouflaged by their fluency and realistic appearance. Uncertainty…

Computation and Language · Computer Science 2025-05-30 Zhiqiu Xia , Jinxuan Xu , Yuqian Zhang , Hang Liu

Language Models (LMs) have shown promising performance in natural language generation. However, as LMs often generate incorrect or hallucinated responses, it is crucial to correctly quantify their uncertainty in responding to given inputs.…

Computation and Language · Computer Science 2024-09-17 Xinmeng Huang , Shuo Li , Mengxin Yu , Matteo Sesia , Hamed Hassani , Insup Lee , Osbert Bastani , Edgar Dobriban

When using large language models (LLMs) in high-stakes applications, we need to know when we can trust their predictions. Some works argue that prompting high-performance LLMs is sufficient to produce calibrated uncertainties, while others…

We introduce BSDetector, a method for detecting bad and speculative answers from a pretrained Large Language Model by estimating a numeric confidence score for any output it generated. Our uncertainty quantification technique works for any…

Computation and Language · Computer Science 2023-10-05 Jiuhai Chen , Jonas Mueller

Uncertainty quantification enables users to assess the reliability of responses generated by large language models (LLMs). We present a novel Question Rephrasing technique to evaluate the input uncertainty of LLMs, which refers to the…

Computation and Language · Computer Science 2024-08-08 Zizhang Chen , Pengyu Hong , Sandeep Madireddy

Large language models (LLMs) are rapidly being integrated into computational social science research, yet their blackboxed training and designed stochastic elements in inference pose unique challenges for scientific inquiry. This article…

Computers and Society · Computer Science 2025-12-08 Bolun Zhang , Linzhuo Li , Yunqi Chen , Qinlin Zhao , Zihan Zhu , Xiaoyuan Yi , Xing Xie

Large Language Models (LLMs) have been widely employed in programming language analysis to enhance human productivity. Yet, their reliability can be compromised by various code distribution shifts, leading to inconsistent outputs. While…

Software Engineering · Computer Science 2024-02-12 Yufei Li , Simin Chen , Yanghong Guo , Wei Yang , Yue Dong , Cong Liu

Large language models (LLMs) are stochastic, and not all models give deterministic answers, even when setting temperature to zero with a fixed random seed. However, few benchmark studies attempt to quantify uncertainty, partly due to the…

Computation and Language · Computer Science 2025-06-30 Robert E. Blackwell , Jon Barry , Anthony G. Cohn

Guaranteeing the correctness and factuality of language model (LM) outputs is a major open problem. In this work, we propose conformal factuality, a framework that can ensure high probability correctness guarantees for LMs by connecting…

Machine Learning · Computer Science 2024-02-20 Christopher Mohri , Tatsunori Hashimoto

As large language models (LLMs) are increasingly used for factual question-answering, it becomes more important for LLMs to have the capability to communicate the likelihood that their answer is correct. For these verbalized expressions of…

Computation and Language · Computer Science 2025-12-15 Sophia Hager , David Mueller , Kevin Duh , Nicholas Andrews