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Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

Deep learning is attracting significant interest in the neuroimaging community as a means to diagnose psychiatric and neurological disorders from structural magnetic resonance images. However, there is a tendency amongst researchers to…

Machine Learning · Computer Science 2019-10-22 David Wood , James Cole , Thomas Booth

Exploring the complex structure of the human brain is crucial for understanding its functionality and diagnosing brain disorders. Thanks to advancements in neuroimaging technology, a novel approach has emerged that involves modeling the…

Machine Learning · Computer Science 2024-06-06 Xuexiong Luo , Jia Wu , Jian Yang , Shan Xue , Amin Beheshti , Quan Z. Sheng , David McAlpine , Paul Sowman , Alexis Giral , Philip S. Yu

Over the past decade, machine learning techniques especially predictive modeling and pattern recognition in biomedical sciences from drug delivery system to medical imaging has become one of the important methods which are assisting…

Computer Vision and Pattern Recognition · Computer Science 2016-03-30 Saman Sarraf , Ghassem Tofighi

Recent neuroimaging studies that focus on predicting brain disorders via modern machine learning approaches commonly include a single modality and rely on supervised over-parameterized models.However, a single modality provides only a…

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of…

Computer Vision and Pattern Recognition · Computer Science 2020-08-28 Wonsik Jung , Eunji Jun , Heung-Il Suk

Mild Cognitive Impairment (MCI) serves as a prodromal stage of Alzheimer's Disease (AD), where early identification and intervention can effectively slow the progression to dementia. However, diagnosing AD remains a significant challenge in…

Artificial Intelligence · Computer Science 2025-11-07 Yutao Jin , Haowen Xiao , Junyong Zhai , Yuxiao Li , Jielei Chu , Fengmao Lv , Yuxiao Li

Alzheimer's disease (AD) affects 50 million people worldwide and is projected to overwhelm 152 million by 2050. AD is characterized by cognitive decline due partly to disruptions in metabolic brain connectivity. Thus, early and accurate…

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused…

Machine Learning · Computer Science 2020-04-01 Sebastian Pölsterl , Ignacio Sarasua , Benjamín Gutiérrez-Becker , Christian Wachinger

In a surprising turn, Large Language Models (LLMs) together with a growing arsenal of prompt-based heuristics now offer powerful off-the-shelf approaches providing few-shot solutions to myriad classic NLP problems. However, despite…

Computation and Language · Computer Science 2023-06-21 Dhananjay Ashok , Zachary C. Lipton

In response to the global challenge of mental health problems, we proposes a Logical Neural Network (LNN) based Neuro-Symbolic AI method for the diagnosis of mental disorders. Due to the lack of effective therapy coverage for mental…

Computation and Language · Computer Science 2023-06-07 Yeldar Toleubay , Don Joven Agravante , Daiki Kimura , Baihan Lin , Djallel Bouneffouf , Michiaki Tatsubori

Alzheimer's disease is characterized by alterations of the brain's structural and functional connectivity during its progressive degenerative processes. Existing auxiliary diagnostic methods have accomplished the classification task, but…

Machine Learning · Computer Science 2021-10-19 Qiankun Zuo , Baiying Lei , Shuqiang Wang , Yong Liu , Bingchuan Wang , Yanyan Shen

Objective: Multi-modal functional magnetic resonance imaging (fMRI) can be used to make predictions about individual behavioral and cognitive traits based on brain connectivity networks. Methods: To take advantage of complementary…

Machine Learning · Computer Science 2024-08-27 Gang Qu , Li Xiao , Wenxing Hu , Kun Zhang , Vince D. Calhoun , Yu-Ping Wang

Brain network discovery aims to find nodes and edges from the spatio-temporal signals obtained by neuroimaging data, such as fMRI scans of human brains. Existing methods tend to derive representative or average brain networks, assuming…

Machine Learning · Computer Science 2023-11-07 Hang Yin , Yao Su , Xinyue Liu , Thomas Hartvigsen , Yanhua Li , Xiangnan Kong

Prompting large language models is a training-free method for detecting Alzheimer's disease from speech transcripts. Using the ADReSS dataset, we revisit zero-shot prompting and study few-shot prompting with a class-balanced protocol using…

Machine Learning · Computer Science 2025-09-25 Jana Sweidan , Mounim A. El-Yacoubi , Nasredine Semmar

Insomnia affects a vast population of the world and can have a wide range of causes. Existing treatments for insomnia have been linked with many side effects like headaches, dizziness, etc. As such, there is a clear need for improved…

Signal Processing · Electrical Eng. & Systems 2025-07-22 Kevin Monteiro , Sam Nallaperuma-Herzberg , Martina Mason , Steve Niederer

Alzheimers disease is a fatal progressive brain disorder that worsens with time. It is high time we have inexpensive and quick clinical diagnostic techniques for early detection and care. In previous studies, various Machine Learning…

Computation and Language · Computer Science 2021-09-27 Akshay Valsaraj , Ithihas Madala , Nikhil Garg , Veeky Baths

Alzheimer's disease (AD) is a neurodegenerative disease that affects nearly 50 million individuals across the globe and is one of the leading causes of deaths globally. It is projected that by 2050, the number of people affected by the…

Machine Learning · Computer Science 2021-10-26 Yash Kumar , Piyush Maheshwari , Shreyansh Joshi , Veeky Baths

Graph neural networks (GNNs) are becoming increasingly popular for EEG-based depression detection. However, previous GNN-based methods fail to sufficiently consider the characteristics of depression, thus limiting their performance.…

Signal Processing · Electrical Eng. & Systems 2026-05-11 Yiye Wang , Wenming Zheng , Yang Li , Hao Yang