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Artificial intelligence is widely used in everyday life. However, an insufficient computing efficiency due to the so-called von Neumann bottleneck cannot satisfy the demand for real-time processing of rapidly growing data. Memristive…

Applied Physics · Physics 2024-02-23 Jing Yang , Lingxiang Hu , Liufeng Shen , Jingrui Wang , Peihong Cheng , Huanming Lu , Fei Zhuge , Zhizhen Ye

Analog computing at the edge is an emerging strategy to limit data storage and transmission requirements, as well as energy consumption, and its practical implementation is in its initial stages of development. Translating properties of…

Signal Processing · Electrical Eng. & Systems 2025-12-09 Giuseppe Leo , Paolo Gibertini , Irem Ilter , Erika Covi , Ole Richter , Elisabetta Chicca

As genome sequencing is finding utility in a wide variety of domains beyond the confines of traditional medical settings, its computational pipeline faces two significant challenges. First, the creation of up to 0.5 GB of data per minute…

Efficient operation of intelligent machines in the real world requires methods that allow them to understand and predict the uncertainties presented by the unstructured environments with good accuracy, scalability and generalization,…

Nowadays a diverse range of physiological data can be captured continuously for various applications in particular wellbeing and healthcare. Such data require efficient methods for classification and analysis. Deep learning algorithms have…

Machine Learning · Computer Science 2018-11-02 Hamid Soleimani , Aliasghar , Makhlooghpour , Wilten Nicola , Claudia Clopath , Emmanuel. M. Drakakis

Reservoir computing is a highly efficient machine learning framework for processing temporal data by extracting features from the input signal and mapping them into higher dimensional spaces. Physical reservoir layers have been realized…

Machine Learning · Computer Science 2023-11-17 Md Razuan Hossain , Ahmed Salah Mohamed , Nicholas Xavier Armendarez , Joseph S. Najem , Md Sakib Hasan

Low-cost, high-throughput DNA and RNA sequencing (HTS) data is the backbone of the life sciences. Genome sequencing is now becoming a part of Predictive, Preventive, Personalized, and Participatory (termed 'P4') medicine. All genomic data…

Memristor crossbar arrays are used in a wide range of in-memory and neuromorphic computing applications. However, memristor devices suffer from non-idealities that result in the variability of conductive states, making programming them to a…

Emerging Technologies · Computer Science 2021-05-13 A. P. James , L. O. Chua

DNA sequencing is the physical/biochemical process of identifying the location of the four bases (Adenine, Guanine, Cytosine, Thymine) in a DNA strand. As semiconductor technology revolutionized computing, modern DNA sequencing technology…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-06 S. Karen Khatamifard , Zamshed Chowdhury , Nakul Pande , Meisam Razaviyayn , Chris Kim , Ulya R. Karpuzcu

Genome analysis fundamentally starts with a process known as read mapping, where sequenced fragments of an organism's genome are compared against a reference genome. Read mapping is currently a major bottleneck in the entire genome analysis…

Hardware Architecture · Computer Science 2020-10-29 Mohammed Alser , Zülal Bingöl , Damla Senol Cali , Jeremie Kim , Saugata Ghose , Can Alkan , Onur Mutlu

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

Hardware Architecture · Computer Science 2021-11-04 Damla Senol Cali

The increasing computational demands of deep learning models pose significant challenges for edge devices. To address this, we propose a memristor-based circuit design for MobileNetV3, specifically for image classification tasks. Our design…

Hardware Architecture · Computer Science 2025-04-04 Jiale Li , Zhihang Liu , Sean Longyu Ma , Chiu-Wing Sham , Chong Fu

MR Fingerprinting is a novel quantitative MR technique that could simultaneously provide multiple tissue property maps. When optimizing MRF scans, modeling undersampling errors and field imperfections in cost functions will make the…

Image and Video Processing · Electrical Eng. & Systems 2021-05-26 Siyuan Hu , Stephen Jordan , Rasim Boyacioglu , Ignacio Rozada , Matthias Troyer , Mark Griswold , Debra McGivney , Dan Ma

Conventional neuro-computing architectures and artificial neural networks have often been developed with no or loose connections to neuroscience. As a consequence, they have largely ignored key features of biological neural processing…

Emerging Technologies · Computer Science 2017-11-08 Giacomo Indiveri , Bernabe Linares-Barranco , Robert Legenstein , George Deligeorgis , Themistoklis Prodromakis

The Von Neumann bottleneck, a fundamental challenge in conventional computer architecture, arises from the inability to execute fetch and data operations simultaneously due to a shared bus linking processing and memory units. This…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-12-10 Md Tawsif Rahman Chowdhury , Huynh Quang Nguyen Vo , Paritosh Ramanan , Murat Yildirim , Gozde Tutuncuoglu

Quantum computer technology harnesses the features of quantum physics for revolutionizing information processing and computing. As such, quantum computers use physical quantum gates that process information unitarily, even though the final…

As neural computation is revolutionizing the field of Artificial Intelligence (AI), rethinking the ideal neural hardware is becoming the next frontier. Fast and reliable von Neumann architecture has been the hosting platform for neural…

Neural and Evolutionary Computing · Computer Science 2024-12-31 Yigit Demirag

This study presents the first implementation of multilayer neural networks on a memristor/CMOS integrated system on chip (SoC) to simultaneously detect multiple diseases. To overcome limitations in medical data, generative AI techniques are…

Hardware Architecture · Computer Science 2024-10-22 Zihan Wang , Daniel W. Yang , Zerui Liu , Evan Yan , Heming Sun , Ning Ge , Miao Hu , Wei Wu

The emerging memristor crossbar array based computing circuits exhibit computing speeds and energy efficiency far surpassing those of traditional digital processors. This type of circuits can complete high-dimensional matrix operations in…

Signal Processing · Electrical Eng. & Systems 2025-06-05 Jia-Hui Bi , Shaoshi Yang , Sheng Chen , Ping Zhang

Hand-sized Deoxyribonucleic acid (DNA) sequencing machines are of growing importance in several life sciences fields as their small footprints enable a broader range of use cases than their larger, stationary counterparts. However, as…

Hardware Architecture · Computer Science 2025-10-13 Abel Beyene , Zhongpan Wu , Yunus Dawji , Karim Hammad , Ebrahim Ghafar-Zadeh , Sebastian Magierowski