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Sensitivity analysis methods such as the Cornfield inequality and the E-value were developed to assess the robustness of observed associations against unmeasured confounding -- a major challenge in observational studies. However, the…

Other Statistics · Statistics 2026-04-10 Qingyan Xiang , Jiahao Zhang , Bojian Feng

Large language models (LLMs) are widely used as scalable evaluators of model responses in lieu of human annotators. However, imperfect sensitivity and specificity of the LLM judges induce bias in naive evaluation scores. We propose a simple…

Machine Learning · Computer Science 2026-02-10 Chungpa Lee , Thomas Zeng , Jongwon Jeong , Jy-yong Sohn , Kangwook Lee

Artificially intelligent (AI) co-scientists must be able to sift through research literature cost-efficiently while applying nuanced scientific reasoning. We evaluate Small Language Models (SLMs, <= 8B parameters) for classifying medical…

Computational Engineering, Finance, and Science · Computer Science 2025-12-09 Muhammed Muaaz Dawood , Mohammad Zaid Moonsamy , Kaela Kokkas , Hairong Wang , Robert F. Breiman , Richard Klein , Emmanuel K. Sekyi , Bruce A. Bassett

Large Language Models (LLMs), characterized by being trained on broad amounts of data in a self-supervised manner, have shown impressive performance across a wide range of tasks. Indeed, their generative abilities have aroused interest on…

Machine Learning · Computer Science 2024-07-30 Jorge García-Carrasco , Alejandro Maté , Juan Trujillo

Introduction. Advances in large language models (LLMs) offer a chance to act as scientific assistants, helping people grasp complex research areas. This study examines how LLMs evolve in healthcare disparities research, with attention to…

Computers and Society · Computer Science 2025-12-10 David An

Instruction-tuned Large Language Models (LLMs) can perform a wide range of tasks given natural language instructions to do so, but they are sensitive to how such instructions are phrased. This issue is especially concerning in healthcare,…

Large language models (LLMs) are increasingly used to generate labels from radiology reports to enable large-scale AI evaluation. However, label noise from LLMs can introduce bias into performance estimates, especially under varying disease…

BACKGROUND: Recent studies have shown that domain-adapted large language models (LLMs) do not consistently outperform general-purpose counterparts on standard medical benchmarks, raising questions about the need for specialized clinical…

Computation and Language · Computer Science 2026-04-09 Ane G. Domingo-Aldama , Iker De La Iglesia , Maitane Urruela , Aitziber Atutxa , Ander Barrena

Large Language Models (LLMs) have demonstrated promise in medical knowledge assessments, yet their practical utility in real-world clinical decision-making remains underexplored. In this study, we evaluated the performance of three…

Computation and Language · Computer Science 2025-12-30 Mengdi Chai , Ali R. Zomorrodi

Large language models (LLMs) hold promise for transforming healthcare, from streamlining administrative and clinical workflows to enriching patient engagement and advancing clinical decision-making. However, their successful integration…

Computers and Society · Computer Science 2025-04-04 Mohammed Al-Garadi , Tushar Mungle , Abdulaziz Ahmed , Abeed Sarker , Zhuqi Miao , Michael E. Matheny

Recent advances in large language models (LLMs) have shown promising results in medical diagnosis, with some studies indicating superior performance compared to human physicians in specific scenarios. However, the diagnostic capabilities of…

Artificial Intelligence · Computer Science 2025-03-24 Zhoujian Sun , Ziyi Liu , Cheng Luo , Jiebin Chu , Zhengxing Huang

Large language models (LLMs) have attracted significant attention for potential applications in digital health, while their application in mental health is subject to ongoing debate. This systematic review aims to evaluate the usage of LLMs…

Computers and Society · Computer Science 2024-08-14 Zhijun Guo , Alvina Lai , Johan Hilge Thygesen , Joseph Farrington , Thomas Keen , Kezhi Li

The advent of Large Language Models (LLMs) has ushered in a new era for design science in Information Systems, demanding a paradigm shift in tailoring LLMs design for business contexts. We propose and test a novel framework to customize…

Computers and Society · Computer Science 2024-05-15 Wen Wang , Zhenyue Zhao , Tianshu Sun

Large Language Models (LLMs) are increasingly used as evaluators of reasoning quality, yet their reliability and bias in payments-risk settings remain poorly understood. We introduce a structured multi-evaluator framework for assessing LLM…

Artificial Intelligence · Computer Science 2026-02-06 Liang Wang , Junpeng Wang , Chin-chia Michael Yeh , Yan Zheng , Jiarui Sun , Xiran Fan , Xin Dai , Yujie Fan , Yiwei Cai

Recently, Large Language Models (LLMs) have showcased remarkable capabilities in natural language understanding. While demonstrating proficiency in everyday conversations and question-answering situations, these models frequently struggle…

Computation and Language · Computer Science 2023-08-28 Chaoyi Wu , Weixiong Lin , Xiaoman Zhang , Ya Zhang , Yanfeng Wang , Weidi Xie

Large Language Models (LLMs) have been widely applied in various professional fields. By fine-tuning the models using domain specific question and answer datasets, the professional domain knowledge and Q\&A abilities of these models have…

Computation and Language · Computer Science 2024-07-17 Qimin Yang , Rongsheng Wang , Jiexin Chen , Runqi Su , Tao Tan

Introduction: Large language models (LLMs) can process requests and generate texts, but their feasibility for assessing complex academic content needs further investigation. To explore LLM's potential in assisting scientific review, this…

Computation and Language · Computer Science 2026-01-29 Yinuo Liu , Emre Sezgin , Eric A. Youngstrom

Purpose: To assess the alignment of GPT-4-based evaluation to human clinician experts, for the evaluation of responses to ophthalmology-related patient queries generated by fine-tuned LLM chatbots. Methods: 400 ophthalmology questions and…

Artificial Intelligence · Computer Science 2024-02-16 Ting Fang Tan , Kabilan Elangovan , Liyuan Jin , Yao Jie , Li Yong , Joshua Lim , Stanley Poh , Wei Yan Ng , Daniel Lim , Yuhe Ke , Nan Liu , Daniel Shu Wei Ting

Lab results are often confusing and hard to understand. Large language models (LLMs) such as ChatGPT have opened a promising avenue for patients to get their questions answered. We aim to assess the feasibility of using LLMs to generate…

Computation and Language · Computer Science 2024-04-23 Zhe He , Balu Bhasuran , Qiao Jin , Shubo Tian , Karim Hanna , Cindy Shavor , Lisbeth Garcia Arguello , Patrick Murray , Zhiyong Lu

Large language models (LLMs) have demonstrated great potential for domain-specific applications, such as the law domain. However, recent disputes over GPT-4's law evaluation raise questions concerning their performance in real-world legal…

Computation and Language · Computer Science 2023-10-19 Ruihao Shui , Yixin Cao , Xiang Wang , Tat-Seng Chua
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