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Ultrasound contrast imaging is a specialized imaging technique that applies microbubble contrast agents to traditional medical sonography, providing real-time visualization of blood flow and vessels. Gas-filled microbubbles are injected…

Analysis of PDEs · Mathematics 2024-12-17 Vanja Nikolić , Teresa Rauscher

The acoustic wave-propagation without mean flow and heat flux can be described in terms of velocity and pressure by the compressible nonlinear Navier-Stokes equations, where boundary layers appear at walls due to the viscosity and a…

Analysis of PDEs · Mathematics 2017-01-10 Anastasia Thoens-Zueva , Kersten Schmidt , Adrien Semin

Motivated by simulations of ultrasound-enhanced drug delivery, this work presents the numerical analysis of a mathematical model that captures the influence of ultrasound waves on the diffusivity of the drug. The system under study consists…

Numerical Analysis · Mathematics 2026-03-10 Femke de Wit , Vanja Nikolić

We investigate a nonlinear multiphysics model motivated by ultrasound-enhanced drug delivery. The acoustic pressure field is modeled by Westervelt's quasilinear wave equation to adequately capture the nonlinear effects in ultrasound…

Analysis of PDEs · Mathematics 2024-12-11 Julio Careaga , Vanja Nikolić , Belkacem Said-Houari

We analyse the ultrasound waves reflected by multiple bubbles in the linearized time-dependent acoustic model. The generated time-dependent wave field is estimated close to the bubbles. The motivation of this study comes from the therapy…

Analysis of PDEs · Mathematics 2024-09-24 Arpan Mukherjee , Mourad Sini

Accurate simulation of nonlinear acoustic waves is essential for the continued development of a wide range of (high-intensity) focused ultrasound applications. This article explores mixed finite element formulations of classical strongly…

Numerical Analysis · Mathematics 2022-09-08 Mostafa Meliani , Vanja Nikolić

Modeling time-harmonic Maxwell problems in heterogeneous media presents significant mathematical and computational challenges. Due to the inherent non-elliptic structure and non-coercive nature of Maxwell equations, conventional methods…

Numerical Analysis · Mathematics 2026-04-30 Xiang Zhong , Eric T. Chung , Xingguang Jin

This paper introduces a novel framework integrating nonlinear acoustic computing and reinforcement learning to enhance advanced human-robot interaction under complex noise and reverberation. Leveraging physically informed wave equations…

Robotics · Computer Science 2025-05-07 Xiaoliang Chen , Xin Yu , Le Chang , Yunhe Huang , Jiashuai He , Shibo Zhang , Jin Li , Likai Lin , Ziyu Zeng , Xianling Tu , Shuyu Zhang

Heating generated by high-intensity focused ultrasound waves is central to many emerging medical applications, including non-invasive cancer therapy and targeted drug delivery. In this study, we aim to gain a fundamental understanding of…

Numerical Analysis · Mathematics 2025-10-03 Julio Careaga , Benjamin Dörich , Vanja Nikolić

The multiscale complexity of modern problems in computational science and engineering can prohibit the use of traditional numerical methods in multi-dimensional simulations. Therefore, novel algorithms are required in these situations to…

Numerical Analysis · Mathematics 2021-06-15 Cale Harnish , Luke Dalessandro , Karel Matous , Daniel Livescu

We present both, theory and an algorithm for solving time-harmonic wave problems in a general setting. The time-harmonic solutions will be achieved by computing time-periodic solutions of the original wave equations. Thus, an exact…

Analysis of PDEs · Mathematics 2011-05-23 Dirk Pauly , Tuomo Rossi

The generation of harmonics by atoms or ions in a two-color, coplanar field configuration with commensurate frequencies is investigated through both, an analytical calculation based on the Lewenstein model and the numerical ab initio…

Atomic Physics · Physics 2009-11-07 F. Ceccherini , D. Bauer , F. Cornolti

With their ability to handle an increased amount of information, multivariate and multichannel signals can be used to solve problems normally not solvable with signals obtained from a single source. One such problem is the decomposition…

Information Theory · Computer Science 2019-04-02 Ljubisa Stankovic , Milos Brajovic , Milos Dakovic , Danilo Mandic

The quasi-accumulation solutions of acoustic wave in a moving fluid are obtained by using the Lagrange parameter variation method to solve the differential equation that describes the interaction between the acoustic waves and the flow. The…

Fluid Dynamics · Physics 2021-02-09 Zuwen Qian

Nonlinear ultrasound imaging leverages harmonic wave generation to enhance contrast and spatial resolution beyond the capabilities of conventional linear techniques. This behavior is commonly modeled by the Westervelt equation, which…

Analysis of PDEs · Mathematics 2026-05-25 Benjamin Rainer , Barbara Kaltenbacher

Subharmonic response from contrast microbubbles as a function of ambient overpressure is numerically investigated for subharmonic aided noninvasive estimation of local organ level blood pressure. Three different interfacial rheological…

Medical Physics · Physics 2015-07-20 Nima Mobadersany , Amit Katiyar , Kausik Sarkar

Time-harmonic solutions to the wave equation can be computed in the frequency or in the time domain. In the frequency domain, one solves a discretized Helmholtz equation, while in the time domain, the periodic solutions to a discretized…

Numerical Analysis · Mathematics 2021-10-26 Christiaan C. Stolk

We consider the application of the WaveHoltz iteration to time-harmonic elastic wave equations with energy conserving boundary conditions. The original WaveHoltz iteration for acoustic Helmholtz problems is a fixed-point iteration that…

Numerical Analysis · Mathematics 2022-09-28 Daniel Appelö , Fortino Garcia , Allen Alvarez Loya , Olof Runborg

Subharmonics emitted from microbubble-based ultrasound contrast agents (UCA) are considered as a noninvasive indicator for diagnostic applications in medical fields. Contrast ultrasound imaging using the modality of subharmonics could be…

Medical Physics · Physics 2021-04-13 Lang Xia

This paper proposes a new hybrid high-order discretization for the biharmonic problem and the corresponding eigenvalue problem. The discrete ansatz space includes degrees of freedom in $n-2$ dimensional submanifolds (e.g., nodal values in…

Numerical Analysis · Mathematics 2026-04-06 Yizhou Liang , Ngoc Tien Tran
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