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Current state-of-the-art generative approaches frequently rely on a two-stage training procedure, where an autoencoder (often a VAE) first performs dimensionality reduction, followed by training a generative model on the learned latent…

Machine Learning · Statistics 2025-07-15 Gianluigi Silvestri , Luca Ambrogioni

Pan-cancer classification using transcriptomic (RNA-Seq) data can inform tumor subtyping and therapy selection, but is challenging due to extremely high dimensionality and limited sample sizes. In this study, we propose a novel deep…

Genomics · Quantitative Biology 2025-08-06 Vinil Polepalli

In this study, a deep learning based conditional density estimation technique known as conditional variational auto-encoder (CVAE) is used to fill gaps typically observed in particle image velocimetry (PIV) measurements in combustion…

Fluid Dynamics · Physics 2023-12-12 Shashank Yellapantula

Deep latent variable models, trained using variational autoencoders or generative adversarial networks, are now a key technique for representation learning of continuous structures. However, applying similar methods to discrete structures,…

Machine Learning · Computer Science 2018-07-02 Jake Zhao , Yoon Kim , Kelly Zhang , Alexander M. Rush , Yann LeCun

We propose a quantum implicit neural representation (QINR)-based autoencoder (AE) and variational autoencoder (VAE) for image reconstruction and generation tasks. Our purpose is to demonstrate that the QINR in VAEs and AEs can transform…

Machine Learning · Computer Science 2026-03-17 Saadet Müzehher Eren

Layout design with complex constraints is a challenging problem to solve due to the non-uniqueness of the solution and the difficulties in incorporating the constraints into the conventional optimization-based methods. In this paper, we…

Signal Processing · Electrical Eng. & Systems 2018-06-11 Yujie Zhang , Wenjing Ye

Deep probabilistic generative models have achieved incredible success in many fields of application. Among such models, variational autoencoders (VAEs) have proved their ability in modeling a generative process by learning a latent…

Machine Learning · Computer Science 2022-12-16 Eleonora Grassucci , Danilo Comminiello , Aurelio Uncini

Probabilistic generative models are attractive for scientific modeling because their inferred parameters can be used to generate hypotheses and design experiments. This requires that the learned model provide an accurate representation of…

Machine Learning · Statistics 2023-01-18 Liyun Tu , Austin Talbot , Neil Gallagher , David Carlson

We propose and demonstrate a generative deep learning approach for the shape recognition of an arbitrary object from its acoustic scattering properties. The strategy exploits deep neural networks to learn the mapping between the latent…

Sound · Computer Science 2022-07-13 W. W. Ahmed , M. Farhat , P. -Y. Chen , X. Zhang , Y. Wu

Nonreciprocal structures play an important role in optical physics and applications. Conventional approaches for designing nonreciprocal optical structures rely heavily on extensive numerical simulation and parameter tuning, leading to high…

Optics · Physics 2026-03-12 Weiran Zhang , Hao Pan , Shubo Wang

We present a new generative autoencoder model with dual contradistinctive losses to improve generative autoencoder that performs simultaneous inference (reconstruction) and synthesis (sampling). Our model, named dual contradistinctive…

Computer Vision and Pattern Recognition · Computer Science 2020-11-23 Gaurav Parmar , Dacheng Li , Kwonjoon Lee , Zhuowen Tu

Materials informatics (MI), which uses artificial intelligence and data analysis techniques to improve the efficiency of materials development, is attracting increasing interest from industry. One of its main applications is the rapid…

Machine Learning · Computer Science 2023-02-07 Yoshihiro Osakabe , Akinori Asahara

Predicting drop coalescence based on process parameters is crucial for experiment design in chemical engineering. However, predictive models can suffer from the lack of training data and more importantly, the label imbalance problem. In…

Computational Engineering, Finance, and Science · Computer Science 2023-05-02 Kewei Zhu , Sibo Cheng , Nina Kovalchuk , Mark Simmons , Yi-Ke Guo , Omar K. Matar , Rossella Arcucci

In data-driven drug discovery, designing molecular descriptors is a very important task. Deep generative models such as variational autoencoders (VAEs) offer a potential solution by designing descriptors as probabilistic latent vectors…

Machine Learning · Computer Science 2023-08-23 Daiki Koge , Naoaki Ono , Shigehiko Kanaya

The variational autoencoder (VAE) framework remains a popular option for training unsupervised generative models, especially for discrete data where generative adversarial networks (GANs) require workaround to create gradient for the…

Machine Learning · Computer Science 2019-04-24 Jason Chou , Gautam Hathi

Deep generative models have been accelerating the inverse design process in material and drug design. Unlike their counterpart property predictors in typical molecular design frameworks, generative molecular design models have seen fewer…

Machine Learning · Computer Science 2024-11-06 A N M Nafiz Abeer , Sanket Jantre , Nathan M Urban , Byung-Jun Yoon

In recent years, the field of machine learning has made phenomenal progress in the pursuit of simulating real-world data generation processes. One notable example of such success is the variational autoencoder (VAE). In this work, with a…

Machine Learning · Statistics 2021-12-30 Hwan Goh , Sheroze Sheriffdeen , Jonathan Wittmer , Tan Bui-Thanh

Design of new drug compounds with target properties is a key area of research in generative modeling. We present a small drug molecule design pipeline based on graph-generative models and a comparison study of two state-of-the-art graph…

Machine Learning · Computer Science 2021-02-10 Logan Ward , Jenna A. Bilbrey , Sutanay Choudhury , Neeraj Kumar , Ganesh Sivaraman

Variational autoencoders (VAEs) are fundamental for generative modeling and image reconstruction, yet their performance often struggles to maintain high fidelity in reconstructions. This study introduces a hybrid model, quantum variational…

Computer Vision and Pattern Recognition · Computer Science 2025-03-10 Farina Riaz , Fakhar Zaman , Hajime Suzuki , Sharif Abuadbba , David Nguyen

Integrating physics models within machine learning models holds considerable promise toward learning robust models with improved interpretability and abilities to extrapolate. In this work, we focus on the integration of incomplete physics…

Machine Learning · Computer Science 2021-10-28 Naoya Takeishi , Alexandros Kalousis