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We propose a modelling framework to analyse the stochastic behaviour of heterogeneous, multi-scale cellular populations. We illustrate our methodology with a particular example in which we study a population with an oxygen-regulated…

Biological Physics · Physics 2017-09-01 Roberto de la Cruz , Pilar Guerrero , Fabian Spill , Tomás Alarcón

Populations of species in ecosystems are often constrained by availability of resources within their environment. In effect this means that a growth of one population, needs to be balanced by comparable reduction in populations of others.…

Populations and Evolution · Quantitative Biology 2016-02-17 Sergei Maslov , Kim Sneppen

We consider an extension of the noisy $N$-Branching Random Walk that models the evolution of a population subject to natural selection. We show the existence of a critical value for the noise which separates the limiting genealogical…

Populations and Evolution · Quantitative Biology 2025-03-17 Emmanuel Schertzer , Alejandro H. Wences

Diffusion based generative models have achieved unprecedented fidelity in synthesizing high dimensional data, yet the theoretical mechanisms governing multimodal generation remain poorly understood. Here, we present a theoretical framework…

Machine Learning · Computer Science 2026-02-10 Emil Albrychiewicz , Andrés Franco Valiente , Li-Ching Chen

Consider a population evolving from year to year through three seasons: spring, summer and winter. Every spring starts with $N$ dormant individuals waking up independently of each other according to a given distribution. Once an individual…

We are interested in the dynamic of a structured branching population where the trait of each individual moves according to a Markov process. The rate of division of each individual is a function of its trait and when a branching event…

Probability · Mathematics 2018-11-20 Aline Marguet

Genomes contain the mutational footprint of an organism's evolutionary history, shaped by diverse forces including ecological factors, selective pressures, and life history traits. The sequentially Markovian coalescent (SMC) is a versatile…

Populations and Evolution · Quantitative Biology 2025-06-03 David Peede , Trevor Cousins , Arun Durvasula , Anastasia Ignatieva , Toby G. L. Kovacs , Alba Nieto , Emily E. Puckett , Elizabeth T. Chevy

We derive exact formulae for the allele frequency spectrum under the coalescent with mutation, conditioned on allele counts at some fixed time in the past. We consider unlinked biallelic markers mutating according to a finite sites, or…

Populations and Evolution · Quantitative Biology 2011-09-19 David Bryant , Arindam RoyChoudhury , Remco Bouckaert , Joseph Felsenstein , Noah Rosenberg

We consider diploid bi-parental analogues of Cannings models: in a population of fixed size $N$ the next generation is composed of $V_{i,j}$ offspring from parents $i$ and $j$, where $V=(V_{i,j})_{1\le i\neq j \le N}$ is a (jointly)…

Probability · Mathematics 2018-03-29 Matthias Birkner , Huili Liu , Anja Sturm

Populations evolving under the joint influence of recombination and resampling (traditionally known as genetic drift) are investigated. First, we summarise and adapt a deterministic approach, as valid for infinite populations, which assumes…

Populations and Evolution · Quantitative Biology 2009-02-20 Ellen Baake , Inke Herms

We consider a model of a population of fixed size $N$ undergoing selection. Each individual acquires beneficial mutations at rate $\mu_N$, and each beneficial mutation increases the individual's fitness by $s_N$. Each individual dies at…

Probability · Mathematics 2015-07-03 Jason Schweinsberg

We study a class of coalescents derived from a sampling procedure out of N i.i.d. Pareto(alpha) random variables, normalized by their sum, including beta-size-biasing on total length effects (beta < alpha). Depending on the range of alpha,…

Probability · Mathematics 2013-02-26 Thierry Huillet

We describe a continuous-time modelling framework for biological population dynamics that accounts for demographic noise. In the spirit of the methodology used by statistical physicists, transitions between the states of the system are…

Populations and Evolution · Quantitative Biology 2018-07-19 George W. A. Constable , Alan J. McKane

We examine genetic statistics used in the study of structured populations. In a 1999 paper, Wakeley observed that the coalescent process associated with the finite island model can be decomposed into a scattering phase and a collecting…

Populations and Evolution · Quantitative Biology 2008-11-11 Sivan Leviyang

Species networks generalize the notion of species trees to allow for hybridization or other lateral gene transfer. Under the Network Multispecies Coalescent Model, individual gene trees arising from a network can have any topology, but…

Populations and Evolution · Quantitative Biology 2019-05-20 Elizabeth Allman , Hector Banos , John Rhodes

Existing studies comparing individual-based models of growing cell populations and their continuum counterparts have mainly focused on homogeneous populations, in which all cells have the same phenotypic characteristics. However,…

Populations and Evolution · Quantitative Biology 2022-06-06 Fiona R Macfarlane , Xinran Ruan , Tommaso Lorenzi

AI training datasets will inevitably contain AI-generated examples, leading to ``feedback'' in which the output of one model impacts the training of another. It is known that such iterative feedback can lead to model collapse, yet the…

Machine Learning · Computer Science 2026-02-24 Vibhas Kumar Vats , David J. Crandall , Samuel Goree

Longitudinal molecular data of rapidly evolving viruses and pathogens provide information about disease spread and complement traditional surveillance approaches based on case count data. The coalescent is used to model the genealogy that…

Applications · Statistics 2020-09-07 Lorenzo Cappello , Julia A. Palacios

We consider an individual-based spatially structured population for Darwinian evolution in an asexual population. The individuals move randomly on a bounded continuous space according to a reflected brownian motion. The dynamics involves…

Probability · Mathematics 2015-09-08 Helene Leman

Most species are structured and influenced by processes that either increased or reduced gene flow between populations. However, most population genetic inference methods ignore population structure and reconstruct a history characterized…

Populations and Evolution · Quantitative Biology 2015-11-10 Olivier Mazet , Willy Rodríguez , Simona Grusea , Simon Boitard , Lounès Chikhi
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