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The extraction of phenotype information which is naturally contained in electronic health records (EHRs) has been found to be useful in various clinical informatics applications such as disease diagnosis. However, due to imprecise…

Computation and Language · Computer Science 2019-11-12 Jingqing Zhang , Xiaoyu Zhang , Kai Sun , Xian Yang , Chengliang Dai , Yike Guo

Latent space models are widely used for analyzing high-dimensional discrete data matrices, such as patient-feature matrices in electronic health records (EHRs), by capturing complex dependence structures through low-dimensional embeddings.…

Machine Learning · Computer Science 2026-02-19 Weijing Tang , Ming Yuan , Zongqi Xia , Tianxi Cai

This paper explores interpretability techniques for two of the most successful learning algorithms in medical decision-making literature: deep neural networks and random forests. We applied these algorithms in a real-world medical dataset…

Machine Learning · Computer Science 2020-02-24 Catarina Moreira , Renuka Sindhgatta , Chun Ouyang , Peter Bruza , Andreas Wichert

Researchers require timely access to real-world longitudinal electronic health records (EHR) to develop, test, validate, and implement machine learning solutions that improve the quality and efficiency of healthcare. In contrast, health…

Machine Learning · Computer Science 2020-12-21 Siddharth Biswal , Soumya Ghosh , Jon Duke , Bradley Malin , Walter Stewart , Jimeng Sun

Due to patient privacy protection concerns, machine learning research in healthcare has been undeniably slower and limited than in other application domains. High-quality, realistic, synthetic electronic health records (EHRs) can be…

Machine Learning · Computer Science 2023-02-10 Huan He , Shifan Zhao , Yuanzhe Xi , Joyce C Ho

In intensive care units (ICUs), critically ill patients are monitored with electroencephalograms (EEGs) to prevent serious brain injury. The number of patients who can be monitored is constrained by the availability of trained physicians to…

Predicting the incidence of complex chronic conditions such as heart failure is challenging. Deep learning models applied to rich electronic health records may improve prediction but remain unexplainable hampering their wider use in medical…

Electronic Health Records (EHR) are data generated during routine clinical care. EHR offer researchers unprecedented phenotypic breadth and depth and have the potential to accelerate the pace of precision medicine at scale. A main EHR…

Quantitative Methods · Quantitative Biology 2017-04-28 Vaclav Papez , Spiros Denaxas , Harry Hemingway

Complex deep learning models show high prediction tasks in various clinical prediction tasks but their inherent complexity makes it more challenging to explain model predictions for clinicians and healthcare providers. Existing research on…

Machine Learning · Computer Science 2026-02-06 Sayantan Kumar , Sean C. Yu , Thomas Kannampallil , Zachary Abrams , Andrew Michelson , Philip R. O. Payne

Deep learning models for clinical event prediction on electronic health records (EHR) often suffer performance degradation when deployed under different data distributions. While domain adaptation (DA) methods can mitigate such shifts, its…

Machine Learning · Computer Science 2026-02-16 Pengfei Hu , Chang Lu , Feifan Liu , Yue Ning

Cohort studies are of significant importance in the field of healthcare analysis. However, existing methods typically involve manual, labor-intensive, and expert-driven pattern definitions or rely on simplistic clustering techniques that…

Machine Learning · Computer Science 2024-06-21 Qingpeng Cai , Kaiping Zheng , H. V. Jagadish , Beng Chin Ooi , James Yip

Machine learning at the edge offers great benefits such as increased privacy and security, low latency, and more autonomy. However, a major challenge is that many devices, in particular edge devices, have very limited memory, weak…

Machine Learning · Computer Science 2019-09-05 Yang Li , Thomas Strohmer

Electronic Health Records (EHR)-based disease prediction models have demonstrated significant clinical value in promoting precision medicine and enabling early intervention. However, existing large language models face two major challenges:…

Computation and Language · Computer Science 2025-06-19 Junke Wang , Hongshun Ling , Li Zhang , Longqian Zhang , Fang Wang , Yuan Gao , Zhi Li

Conventional machine learning models, particularly tree-based approaches, have demonstrated promising performance across various clinical prediction tasks using electronic health record (EHR) data. Despite their strengths, these models…

Computation and Language · Computer Science 2025-05-26 Sara Ketabi , Dhanesh Ramachandram

In recent years, increasingly augmentation of health data, such as patient Electronic Health Records (EHR), are becoming readily available. This provides an unprecedented opportunity for knowledge discovery and data mining algorithms to dig…

Machine Learning · Computer Science 2019-05-09 Xi Sheryl Zhang , Fengyi Tang , Hiroko Dodge , Jiayu Zhou , Fei Wang

Interpretability of deep learning is widely used to evaluate the reliability of medical imaging models and reduce the risks of inaccurate patient recommendations. For models exceeding human performance, e.g. predicting RNA structure from…

Quantitative Methods · Quantitative Biology 2022-08-31 Mara Graziani , Niccolò Marini , Nicolas Deutschmann , Nikita Janakarajan , Henning Müller , María Rodríguez Martínez

Deep learning models for survival analysis have gained significant attention in the literature, but they suffer from severe performance deficits when the dataset contains many irrelevant features. We give empirical evidence for this problem…

Machine Learning · Computer Science 2019-03-08 Carl Rietschel , Jinsung Yoon , Mihaela van der Schaar

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer

Medical crowdfunding is a popular channel for people needing financial help paying medical bills to collect donations from large numbers of people. However, large heterogeneity exists in donations across cases, and fundraisers face…

Machine Learning · Computer Science 2019-11-25 Tong Wang , Fujie Jin , Yu Hu , Yuan Cheng

Deriving disease subtypes from electronic health records (EHRs) can guide next-generation personalized medicine. However, challenges in summarizing and representing patient data prevent widespread practice of scalable EHR-based…

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