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In chemical processing and bioprocessing, conventional online sensors are limited to measure only basic process variables like pressure and temperature, pH, dissolved O and CO$_2$ and viable cell density (VCD). The concentration of other…

Quantitative Methods · Quantitative Biology 2020-05-07 Semion Rozov

Raman spectroscopy's capability to provide meaningful composition predictions is heavily reliant on a pre-processing step to remove insignificant spectral variation. This is crucial in biofluid analysis. Widespread adoption of diagnostics…

Signal Processing · Electrical Eng. & Systems 2019-04-05 Emily E Storey , Amr S. Helmy

We demonstrate novel instrumentation for spontaneous Raman spectroscopy in biofluids, enabling development of a portable, automated, reliable diagnostics technique requiring minimal operator expertise to quantify disease markers. Label-free…

Biological Physics · Physics 2021-05-27 Emily E. Storey , Duxuan Wu , Amr S. Helmy

Here we design, construct, and characterize a compact Raman-spectroscopy-based sensor that measures the concentration of a water-methanol mixture. The sensor measures the concentration with an accuracy of 0.5% and a precision of 0.2% with a…

Instrumentation and Detectors · Physics 2018-08-16 Daniel D. Hickstein , Russell Goldfarmmuren , Jack Darrah , Luke Erickson , Laura A. Johnson

We present results of Raman spectroscopic studies of urine to determine the suitability of near-infrared Raman spectroscopy for quantitative estimation of urinary urea. The Raman spectra were acquired from the urine samples with an inbuilt…

Medical Physics · Physics 2014-12-24 S. Kumar , S. K. Majumdar

Although Raman spectroscopy is widely used for the investigation of biomedical samples and has a high potential for use in clinical applications, it is not common in clinical routines. One of the factors that obstruct the integration of…

Data Analysis, Statistics and Probability · Physics 2022-01-20 Darina Storozhuk , Oleg Ryabchykov , Juergen Popp , Thomas Bocklitz

Confocal Raman microscopy offers a particular pathway for monitoring chemical "fingerprints" of intracellular components like the cell membrane, organelles, and nucleus. Nevertheless, conventional Raman acquisitions of fixed or randomly…

Raman spectroscopy enables non-destructive, label-free imaging with unprecedented molecular contrast but is limited by slow data acquisition, largely preventing high-throughput imaging applications. Here, we present a comprehensive…

Image and Video Processing · Electrical Eng. & Systems 2021-12-02 Conor C. Horgan , Magnus Jensen , Anika Nagelkerke , Jean-Phillipe St-Pierre , Tom Vercauteren , Molly M. Stevens , Mads S. Bergholt

Raman scattering spectroscopy is widely used as an analytical technique in various fields, but its measurement process tends to be slow due to the low scattering cross-section. In the last decade, various broadband coherent Raman scattering…

Optics · Physics 2025-05-06 Takuma Nakamura , Kazuki Hashimoto , Takuro Ideguchi

This paper addresses the gap between the capabilities and utilisation of robotics and automation in laboratory settings and builds upon the concept of Self Driving Labs (SDL). %to significantly impact laboratory operations. We introduce an…

Systems and Control · Electrical Eng. & Systems 2024-02-20 Shayan Azizi , Ehsan Asadi , Shaun Howard , Benjamin W. Muir , Riley O'Shea , Alireza Bab-Hadiashar

Raman spectroscopy is a widely-used non-destructive material characterization method, which provides information about the vibrational modes of the material and therefore of its atomic structure and chemical composition. Interpretation of…

Computational Physics · Physics 2023-02-09 Mohammad Bagheri , Hannu-Pekka Komsa

Surface enhanced Raman spectroscopy, is a technique of fundamental importance to analytical science and technology where the amplified Raman spectrum of analytes is used for chemical fingerprinting. Here, we showcase an engineered…

Applied Physics · Physics 2021-06-08 K N Prajapati , Anoop A Nair , S Ravi P Silva , J Mitra

Raman spectroscopy is an important tool in the study of vibrational properties and composition of molecules, peptides and even proteins. Raman spectra can be simulated based on the change of the electronic polarizability with vibrations,…

Computational Physics · Physics 2024-04-30 Ethan Berger , Juha Niemelä , Outi Lampela , André H. Juffer , Hannu-Pekka Komsa

This study explores the deployment of three machine learning (ML) approaches for real-time prediction of glucose, lactate, and ammonium concentrations in cell culture processes, using Raman spectroscopy as input features. The research…

Quantitative Methods · Quantitative Biology 2025-09-04 Thanh Tung Khuat , Johnny Peng , Robert Bassett , Ellen Otte , Bogdan Gabrys

Reliable identification of high-value products such as whisky is an increasingly important area, as issues such as brand substitution (i.e. fraudulent products) and quality control are critical to the industry. We have examined a range of…

Segment Anything Model (SAM) is drastically accelerating the speed and accuracy of automatically segmenting and labeling large Red-Green-Blue (RGB) imagery datasets. However, SAM is unable to segment and label images outside of the visible…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 James E. Gallagher , Aryav Gogia , Edward J. Oughton

In general, most of the substances in nature exist in mixtures, and the noninvasive identification of mixture composition with high speed and accuracy remains a difficult task. However, the development of Raman spectroscopy, machine…

Signal Processing · Electrical Eng. & Systems 2022-02-02 Liangrui Pan , Peng Zhang , Chalongrat Daengngam , Mitchai Chongcheawchamnan

Automation can transform productivity in research activities that use liquid handling, such as organic synthesis, but it has made less impact in materials laboratories, which require sample preparation steps and a range of solid-state…

The extensive use of pesticides and synthetic dyes poses critical threats to food safety, human health, and environmental sustainability, necessitating rapid and reliable detection methods. Raman spectroscopy offers molecularly specific…

Materials Science · Physics 2025-11-18 Quach Thi Thai Binh , Thuan Phuoc , Xuan Hai , Thang Bach Phan , Vu Thi Hanh Thu , Nguyen Tuan Hung

Raman spectroscopy is frequently used to identify composition, structure and layer thickness of 2D materials. Here, we describe an efficient first-principles workflow for calculating resonant first-order Raman spectra of solids within…

Materials Science · Physics 2020-07-15 A. Taghizadeh , U. Leffers , T. G. Pedersen , K. S. Thygesen
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