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The complexity of biological systems and processes, spanning molecular to macroscopic scales, necessitates the use of multiscale simulations to get a comprehensive understanding. Quantum mechanics/molecular mechanics (QM/MM) molecular…

Computational micromagnetics requires numerical solution of partial differential equations to resolve complex interactions in magnetic nanomaterials. The Virtual Micromagnetics project described here provides virtual machine simulation…

Other Computer Science · Computer Science 2016-11-28 Mark Vousden , Marc-Antonio Bisotti , Maximilian Albert , Hans Fangohr

Last several years, GPUs are used to accelerate computations in many computer science domains. We focused on GPU accelerated Support Vector Machines (SVM) training with non-linear kernel functions. We had searched for all available GPU…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-07-21 Jan Vanek , Josef Michalek , Josef Psutka

The comparison of computer generated protein structural models is an important element of protein structure prediction. It has many uses including model quality evaluation, selection of the final models from a large set of candidates or…

Computational Engineering, Finance, and Science · Computer Science 2011-07-27 Paweł Widera , Natalio Krasnogor

We present a detailed strong and weak scaling analysis of PICCANTE, an open source, massively parallel, fully-relativistic Particle-In-Cell (PIC) code. PIC codes are widely used in plasma physics and astrophysics to study the cases where…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-03-27 Andrea Sgattoni , Luca Fedeli , Stefano Sinigardi , Alberto Marocchino , Andrea Macchi , Volker Weinberg , Anupam Karmakar

Folding protein dynamics has been an area of high interest for quite some time, especially given the increased focus on the field of Biophysics. Because folding dynamics occur on such short time scales, empirical techniques developed for…

Soft Condensed Matter · Physics 2022-10-11 Rickie Xian

Background: The development, optimization and validation of protein modeling methods require efficient tools for structural comparison. Frequently, a large number of models need to be compared with the target native structure. The main…

Biomolecules · Quantitative Biology 2013-03-04 Jamróz Michał , Koliński Andrzej

Room-temperature metals and semi-metals which consist of a gas of bound electrons in a near-continuum band structure can be classified as cold quantum plasmas. This insight suggests that Particle-in-Cell (PIC) simulations, traditionally…

Plasma Physics · Physics 2025-01-14 Gregory K. Ngirmang , Hue T. B. Do , Guangxin Liu , Michel Bosman , Lin Wu

ESPResSo 4.0 is an extensible simulation package for research on soft matter. This versatile molecular dynamics program was originally developed for coarse-grained simulations of charged systems Limbach et al., Comput. Phys. Commun. 174,…

Interactions of molecules with their environment influence the course and outcome of almost all chemical reactions. However, classical computers struggle to accurately simulate complicated molecule-environment interactions because of the…

We describe a highly optimized implementation of MPI domain decomposition in a GPU-enabled, general-purpose molecular dynamics code, HOOMD-blue (Anderson and Glotzer, arXiv:1308.5587). Our approach is inspired by a traditional CPU-based…

Owing to the computational complexity of electronic structure algorithms running on classical digital computers, the range of molecular systems amenable to simulation remains tightly circumscribed even after many decades of work. Quantum…

Quantum Physics · Physics 2022-05-18 Alexis Ralli , Michael I. Williams , Peter V. Coveney

Large protein assemblies, such as virus capsids, may be coarse-grained as a set of rigid domains linked by generalized (rotational and stretching) harmonic springs. We present a method to obtain the elastic parameters and overdamped…

Biomolecules · Quantitative Biology 2013-05-29 Stephen D. Hicks , C. L. Henley

A software package has been developed to bridge the R analysis model with the conceptual analysis environment typical of radiation physics experiments. The new package has been used in the context of a project for the validation of…

Computational Physics · Physics 2013-11-25 Andreas Pfeiffer , Maria Grazia Pia

Many researches have been working on the protein folding problem from more than half century. Protein folding is indeed one of the major unsolved problems in science. In this work, we discuss a model for the simulation of protein…

Optimization and Control · Mathematics 2008-11-20 A. Mucherino , O. Seref , P. M. Pardalos

We develop a multi-scale approach to simulate hydrated nanobio systems under realistic condi- tions (e.g., nanoparticles and protein solutions at physiological conditions over time-scales up to hours). We combine atomistic simulations of…

Soft Condensed Matter · Physics 2017-07-05 Oriol Vilanova , Valentino Bianco , Giancarlo Franzese

Simulation of non-adiabatic dynamics of a quantum system coupled to dissipative environments poses significant challenges. New sophisticated methods are regularly being developed with an eye towards moving to larger systems and more…

Quantum Physics · Physics 2023-06-07 Amartya Bose

Quantum Mechanics/Molecular Mechanics (QM/MM) simulations are a popular approach to study various features of large systems. A common application of QM/MM calculations is in the investigation of reaction mechanisms in condensed-phase and…

Chemical Physics · Physics 2020-10-29 Jorge Nochebuena , Sehr Naseem-Khan , G. Andrés Cisneros

Computational systems and methods are often being used in biological research, including the understanding of cancer and the development of treatments. Simulations of tumor growth and its response to different drugs are of particular…

The Probe-Particle Model combine theories designed for the simulation of scanning probe microscopy experiments, employing non-reactive, flexible tip apices to achieve sub-molecular resolution. In the article we present the latest version of…

Mesoscale and Nanoscale Physics · Physics 2024-07-02 Niko Oinonen , Aliaksandr V. Yakutovich , Aurelio Gallardo , Martin Ondracek , Prokop Hapala , Ondrej Krejci