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The mammalian brain is a metabolically expensive device, and evolutionary pressures have presumably driven it to make productive use of its resources. For sensory areas, this concept has been expressed more formally as an optimality…

Neurons and Cognition · Quantitative Biology 2016-03-02 Deep Ganguli , Eero P. Simoncelli

We explore a suite of generative modelling techniques to efficiently navigate and explore the complex landscapes of odor and the broader chemical space. Unlike traditional approaches, we not only generate molecules but also predict the odor…

Machine Learning · Computer Science 2025-02-03 Mrityunjay Sharma , Sarabeshwar Balaji , Pinaki Saha , Ritesh Kumar

The olfactory search POMDP (partially observable Markov decision process) is a sequential decision-making problem designed to mimic the task faced by insects searching for a source of odor in turbulence, and its solutions have applications…

Robotics · Computer Science 2023-03-21 Aurore Loisy , Robin A. Heinonen

Information theoretical tools are applied for the study of the sensitivity and selectivity enhancements of resistive fluctuation-enhanced sensors. General considerations are given for the upper limit of selectivity enhancement. The…

General Physics · Physics 2008-07-06 Laszlo B. Kish , Janusz Smulko , Peter Heszler , Claes-Goran Granqvist

The gain of neurons' responses in the auditory cortex is sensitive to contrast changes in the stimulus within a spectrotemporal range similar to their receptive fields, which can be interpreted to represent the tuning of the input to a…

Neurons and Cognition · Quantitative Biology 2013-10-23 Linus J. Schumacher , Geoff K. Nicholls

Advances in neural recording methods enable sampling from populations of thousands of neurons during the performance of behavioral tasks, raising the question of how recorded activity relates to the theoretical models of computations…

Neurons and Cognition · Quantitative Biology 2020-07-01 Audrey J. Sederberg , Ilya Nemenman

The olfactory system of male moths is exquisitely sensitive to pheromones emitted by females and transported in the environment by atmospheric turbulence. Moths respond to minute amounts of pheromones and their behavior is sensitive to the…

Quantitative Methods · Quantitative Biology 2014-11-14 Antonio Celani , Emmanuel Villermaux , Massimo Vergassola

The insect olfactory system, which includes the antennal lobe (AL), mushroom body (MB), and ancillary structures, is a relatively simple neural system capable of learning. Its structural features, which are widespread in biological neural…

Neurons and Cognition · Quantitative Biology 2018-02-09 Charles B. Delahunt , Jeffrey A. Riffell , J. Nathan Kutz

This research introduces a Machine Learning-centric approach to replicate olfactory experiences, validated through experimental quantification of perfume perception. Key contributions encompass a hybrid model connecting perfume molecular…

The prediction of odor characters is still impossible based on the odorant molecular structure. We designed a CNN-based regressor for computed parameters in molecular vibrations (CNN\_vib), in order to investigate the ability to predict…

Chemical Physics · Physics 2025-09-23 Yuki Harada , Shuichi Maeda , Junwei Shen , Taku Misonou , Hirokazu Hori , Shinichiro Nakamura

Reward models are crucial for aligning large language models (LLMs) with human values and intentions. Existing approaches follow either Generative (GRMs) or Discriminative (DRMs) paradigms, yet both suffer from limitations: GRMs typically…

Computation and Language · Computer Science 2026-03-03 Longze Chen , Lu Wang , Renke Shan , Ze Gong , Run Luo , Jiaming Li , Jing Luo , Qiyao Wang , Min Yang

We present a generalized theoretical framework for olfactory representation and plasticity, using the theory of smooth manifolds and sheaves to depict categorical odor learning via distributed neural computation. Beginning with the space of…

Neurons and Cognition · Quantitative Biology 2023-10-13 Jack A. Cook , Thomas A. Cleland

Understanding how molecular structure gives rise to odor perception remains a long-standing challenge, with ongoing debate over whether olfaction is primarily governed by molecular shape, vibrational properties, or their interplay at the…

Materials Science · Physics 2026-04-14 P. Zanineli , E. V. C. Lopes , G. R. Schleder , L. N. Lemos , F. Crasto de Lima , A. Fazzio

State-of-the-art methods for object detection use region proposal networks (RPN) to hypothesize object location. These networks simultaneously predicts object bounding boxes and \emph{objectness} scores at each location in the image. Unlike…

Computer Vision and Pattern Recognition · Computer Science 2018-12-27 Awais Mansoor , Antonio R. Porras , Marius George Linguraru

In specific motifs of three recurrently connected neurons with probabilistic response, the spontaneous information flux, defined as the mutual information between subsequent states, has been shown to increase by adding ongoing white noise…

Neurons and Cognition · Quantitative Biology 2024-08-13 Claus Metzner , Achim Schilling , Andreas Maier , Patrick Krauss

Navigation by scent is a capability in robotic systems that is rising in demand. However, current methods often suffer from ambiguities, particularly when robots misattribute odours to incorrect objects due to limitations in olfactory…

Robotics · Computer Science 2025-09-23 Kordel K. France , Ovidiu Daescu

Olfactory perception plays a critical role in both human and organismal interactions, yet understanding of its underlying mechanisms and influencing factors remain insufficient. Molecular structures influence odor perception through…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Jian Wang

Advances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how they…

Neurons and Cognition · Quantitative Biology 2024-04-09 Vivek Agarwal , Joshua Harvey , Dmitry Rinberg , Vasant Dhar

We present a novel machine learning architecture for classification suggested by experiments on olfactory systems. The network separates input stimuli, represented as spatially distinct currents, via winnerless competition---a process based…

Biological Physics · Physics 2020-06-18 Jason A. Platt , Anna Miller , Lawson Fuller , Henry D. I. Abarbanel

We present a theoretical investigation on possible selection of olfactory receptors (ORs) as sensing components of nanobiosensors. Accordingly, we generate the impedance spectra of the rat OR I7 in the native and activated state and analyze…

Biomolecules · Quantitative Biology 2011-02-17 Eleonora Alfinito , Cecilia Pennetta , Lino Reggiani