English
Related papers

Related papers: Inferring genotype-phenotype maps using attention …

200 papers

Understanding how genes influence phenotype across species is a fundamental challenge in genetic engineering, which will facilitate advances in various fields such as crop breeding, conservation biology, and personalized medicine. However,…

Machine Learning · Computer Science 2025-03-11 Mengdi Liu , Zhangyang Gao , Hong Chang , Stan Z. Li , Shiguang Shan , Xilin Chen

In the classic view introduced by R. A. Fisher, a quantitative trait is encoded by many loci with small, additive effects. Recent advances in QTL mapping have begun to elucidate the genetic architectures underlying vast numbers of…

Populations and Evolution · Quantitative Biology 2013-10-04 Etienne Rajon , Joshua B. Plotkin

Attention-based neural networks, such as Transformers, have become ubiquitous in numerous applications, including computer vision, natural language processing, and time-series analysis. In all kinds of attention networks, the attention maps…

Machine Learning · Computer Science 2023-05-01 Yujing Wang , Yaming Yang , Zhuo Li , Jiangang Bai , Mingliang Zhang , Xiangtai Li , Jing Yu , Ce Zhang , Gao Huang , Yunhai Tong

As the amount and complexity of genetic information increases it is necessary that we explore some efficient ways of handling these data. This study takes the "divide and conquer" approach for analyzing high dimensional genomic data. Our…

Applications · Statistics 2013-08-15 Deniz Akdemir

Many real-world problems can be represented as graph-based learning problems. In this paper, we propose a novel framework for learning spatial and attentional convolution neural networks on arbitrary graphs. Different from previous…

Machine Learning · Computer Science 2019-02-26 Hao Peng , Jianxin Li , Qiran Gong , Senzhang Wang , Yuanxing Ning , Philip S. Yu

Sequence labeling architectures use word embeddings for capturing similarity, but suffer when handling previously unseen or rare words. We investigate character-level extensions to such models and propose a novel architecture for combining…

Computation and Language · Computer Science 2016-11-15 Marek Rei , Gamal K. O. Crichton , Sampo Pyysalo

We propose an attention-based method that aggregates local image features to a subject-level representation for predicting disease severity. In contrast to classical deep learning that requires a fixed dimensional input, our method operates…

Computer Vision and Pattern Recognition · Computer Science 2018-07-02 Sumedha Singla , Mingming Gong , Siamak Ravanbakhsh , Frank Sciurba , Barnabas Poczos , Kayhan N. Batmanghelich

Recurrent neural networks with differentiable attention mechanisms have had success in generative and classification tasks. We show that the classification performance of such models can be enhanced by guiding a randomly initialized model…

Machine Learning · Computer Science 2017-12-18 Jack Lindsey

Causal inference approaches in systems genetics exploit quantitative trait loci (QTL) genotypes to infer causal relationships among phenotypes. The genetic architecture of each phenotype may be complex, and poorly estimated genetic…

Applications · Statistics 2010-10-08 Elias Chaibub Neto , Mark P. Keller , Alan D. Attie , Brian S. Yandell

The functions of proteins and RNAs are determined by a myriad of interactions between their constituent residues, but most quantitative models of how molecular phenotype depends on genotype must approximate this by simple additive effects.…

Quantitative Methods · Quantitative Biology 2017-12-19 Adam J. Riesselman , John B. Ingraham , Debora S. Marks

Transformer-based architectures have become the prevailing backbone of large language models. However, the quadratic time and memory complexity of self-attention remains a fundamental obstacle to efficient long-context modeling. To address…

Computation and Language · Computer Science 2026-02-10 Yutao Sun , Zhenyu Li , Yike Zhang , Tengyu Pan , Bowen Dong , Yuyi Guo , Jianyong Wang

A substantial body of research has focused on developing systems that assist medical professionals during labor-intensive early screening processes, many based on convolutional deep-learning architectures. Recently, multiple studies…

Computer Vision and Pattern Recognition · Computer Science 2024-04-19 Tristan Piater , Niklas Penzel , Gideon Stein , Joachim Denzler

Heritability is a central parameter in quantitative genetics, both from an evolutionary and a breeding perspective. For plant traits heritability is traditionally estimated by comparing within and between genotype variability. This approach…

Knowledge bases, and their representations in the form of knowledge graphs (KGs), are naturally incomplete. Since scientific and industrial applications have extensively adopted them, there is a high demand for solutions that complete their…

Artificial Intelligence · Computer Science 2025-07-30 Vítor Lourenço , Aline Paes

Methods for time series prediction and classification of gene regulatory networks (GRNs) from gene expression data have been treated separately so far. The recent emergence of attention-based recurrent neural networks (RNN) models boosted…

Attention Model has now become an important concept in neural networks that has been researched within diverse application domains. This survey provides a structured and comprehensive overview of the developments in modeling attention. In…

Machine Learning · Computer Science 2021-07-13 Sneha Chaudhari , Varun Mithal , Gungor Polatkan , Rohan Ramanath

Accurate prediction of crop yield supported by scientific and domain-relevant insights, can help improve agricultural breeding, provide monitoring across diverse climatic conditions and thereby protect against climatic challenges to crop…

The research explores the utilization of a deep learning model employing an attention mechanism in medical text mining. It targets the challenge of analyzing unstructured text information within medical data. This research seeks to enhance…

Computation and Language · Computer Science 2024-06-04 Lingxi Xiao , Muqing Li , Yinqiu Feng , Meiqi Wang , Ziyi Zhu , Zexi Chen

Although group convolutional networks are able to learn powerful representations based on symmetry patterns, they lack explicit means to learn meaningful relationships among them (e.g., relative positions and poses). In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2020-07-01 David W. Romero , Erik J. Bekkers , Jakub M. Tomczak , Mark Hoogendoorn

Attention-based models are successful when trained on large amounts of data. In this paper, we demonstrate that even in the low-resource scenario, attention can be learned effectively. To this end, we start with discrete human-annotated…

Computation and Language · Computer Science 2018-08-29 Yujia Bao , Shiyu Chang , Mo Yu , Regina Barzilay