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Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

Biomolecules · Quantitative Biology 2025-01-06 Weihang Dai

We perform event-driven molecular dynamics simulations of a system composed by uniaxial hard ellipsoids for different values of the aspect-ratio and packing fraction . We compare the molecular orientational-dependent structure factors…

Soft Condensed Matter · Physics 2012-07-06 Cristiano De Michele , Antonio Scala , Rolf Schilling , Francesco Sciortino

Recent advances in protein function prediction exploit graph-based deep learning approaches to correlate the structural and topological features of proteins with their molecular functions. However, proteins in vivo are not static but…

Biomolecules · Quantitative Biology 2022-11-22 Yuan Chiang , Wei-Han Hui , Shu-Wei Chang

Biological neurons communicate with a sparing exchange of pulses - spikes. It is an open question how real spiking neurons produce the kind of powerful neural computation that is possible with deep artificial neural networks, using only so…

Neural and Evolutionary Computing · Computer Science 2016-09-08 Davide Zambrano , Sander M. Bohte

Proteins perform critical processes in all living systems: converting solar energy into chemical energy, replicating DNA, as the basis of highly performant materials, sensing and much more. While an incredible range of functionality has…

Biomolecules · Quantitative Biology 2021-09-29 Leonardo V. Castorina , Rokas Petrenas , Kartic Subr , Christopher W. Wood

Design considerations for molecular dynamics algorithms capable of taking advantage of the computational power of a graphics processing unit (GPU) are described. Accommodating the constraints of scalable streaming-multiprocessor hardware…

Computational Physics · Physics 2011-01-27 D. C. Rapaport

We provide a detailed user guide for SMARTIES, a suite of Matlab codes for the calculation of the optical properties of oblate and prolate spheroidal particles, with comparable capabilities and ease-of-use as Mie theory for spheres.…

Optics · Physics 2016-02-08 W. R. C. Somerville , B. Auguié , E. C. Le Ru

Achieving fast and reliable temporal signal encoding is crucial for low-power, always-on systems. While current spike-based encoding algorithms rely on complex networks or precise timing references, simple and robust encoding models can be…

Neural and Evolutionary Computing · Computer Science 2025-04-23 Filippo Costa , Chiara De Luca

Deep learning-based computational methods have achieved promising results in predicting protein-protein interactions (PPIs). However, existing benchmarks predominantly focus on isolated pairwise evaluations, overlooking a model's capability…

Machine Learning · Computer Science 2025-10-23 Xinzhe Zheng , Hao Du , Fanding Xu , Jinzhe Li , Zhiyuan Liu , Wenkang Wang , Tao Chen , Wanli Ouyang , Stan Z. Li , Yan Lu , Nanqing Dong , Yang Zhang

The non-orthogonal local submatrix method applied to electronic-structure based molecular dynamics simulations is shown to exceed 1.1 EFLOP/s in FP16/FP32 mixed floating-point arithmetic when using 4,400 NVIDIA A100 GPUs of the Perlmutter…

Computational Physics · Physics 2022-06-08 Robert Schade , Tobias Kenter , Hossam Elgabarty , Michael Lass , Thomas D. Kühne , Christian Plessl

This work presents the implementation of a fragment-based, quantum-centric supercomputing workflow for computing molecular electronic structure using quantum hardware. The workflow is applied to predict the relative energies of two…

Over the last decade, researchers have been working to improve a crucial aspect of quantum computing to predict Hamiltonian energy of solids. Quantum algorithms such as Variational Quantum Eigensolver (VQE) and Variational Quantum Deflation…

Materials Science · Physics 2025-09-03 Naman Khandelwal , Nidhi Verma , Pooja Jamdagni , Ashok Kumar

As neural computation is revolutionizing the field of Artificial Intelligence (AI), rethinking the ideal neural hardware is becoming the next frontier. Fast and reliable von Neumann architecture has been the hosting platform for neural…

Neural and Evolutionary Computing · Computer Science 2024-12-31 Yigit Demirag

The freud Python package is a powerful library for analyzing simulation data. Written with modern simulation and data analysis workflows in mind, freud provides a Python interface to fast, parallelized C++ routines that run efficiently on…

Spiking neural networks are the basis of versatile and power-efficient information processing in the brain. Although we currently lack a detailed understanding of how these networks compute, recently developed optimization techniques allow…

Neural and Evolutionary Computing · Computer Science 2021-01-01 Benjamin Cramer , Yannik Stradmann , Johannes Schemmel , Friedemann Zenke

Following the success of Moore's predictions, we are approaching a limit in the miniaturization of semiconductors for computing materials. This has led to the exploration of various research paths to develop alternative computing paradigms,…

Quantum Physics · Physics 2026-05-20 Dawit Hiluf Hailu

A promising platform for quantum information processing is that of silicon impurities, where the quantum states are manipulated by magnetic resonance. Such systems, in abstraction, can be considered as a nucleus of arbitrary spin coupled to…

Quantum Physics · Physics 2013-05-07 M. H. Mohammady

While classical neural networks take a position of a leading method in the machine learning community, spiking neuromorphic systems bring attention and large projects in neuroscience. Spiking neural networks were shown to be able to…

Neural and Evolutionary Computing · Computer Science 2016-04-07 Sergei Dytckov , Masoud Daneshtalab

P systems are computing conceptual computing devices that are at least as powerful as Turing machines. However, until recently it was not known how one can encode any recursive function as a P~system. Here we propose a new encoding of…

Formal Languages and Automata Theory · Computer Science 2018-09-25 Apostolos Syropoulos , Stratos Doumanis , Konstantinos T. Sotiriades

Accurately predicting protein structures from amino acid sequences remains a fundamental challenge in computational biology, with profound implications for understanding biological functions and enabling structure-based drug discovery.…

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