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Time series data from the Intensive Care Unit (ICU) provides critical information for patient monitoring. While recent advancements in applying Large Language Models (LLMs) to time series modeling (TSM) have shown great promise, their…

Machine Learning · Computer Science 2026-01-27 Feixiang Zheng , Yu Wu , Cecilia Mascolo , Ting Dang

Clinical language models have achieved strong performance on downstream tasks by pretraining on domain specific corpora such as discharge summaries and medical notes. However, most approaches treat the electronic health record as a static…

Computation and Language · Computer Science 2025-04-28 Tatsunori Tanaka , Fi Zheng , Kai Sato , Zhifeng Li , Yuanyun Zhang , Shi Li

Tokenization strategies shape how models process electronic health records, yet fair comparisons of their effectiveness remain limited. We present a systematic evaluation of tokenization approaches for clinical time series modeling using…

Machine Learning · Computer Science 2025-12-08 Rafi Al Attrach , Rajna Fani , David Restrepo , Yugang Jia , Peter Schüffler

Timing of clinical events is central to characterization of patient trajectories, enabling analyses such as process tracing, forecasting, and causal reasoning. However, structured electronic health records capture few data elements critical…

Computation and Language · Computer Science 2025-04-18 Jing Wang , Jeremy C Weiss

The adaptation of large language models (LLMs) to time series forecasting poses unique challenges, as time series data is continuous in nature, while LLMs operate on discrete tokens. Despite the success of LLMs in natural language…

Computation and Language · Computer Science 2025-08-05 Taibiao Zhao , Xiaobing Chen , Mingxuan Sun

Time series analysis provides essential insights for real-world system dynamics and informs downstream decision-making, yet most existing methods often overlook the rich contextual signals present in auxiliary modalities. To bridge this…

Machine Learning · Computer Science 2026-03-24 Yushan Jiang , Wenchao Yu , Geon Lee , Dongjin Song , Kijung Shin , Wei Cheng , Yanchi Liu , Haifeng Chen

High-dimensional observations are a major challenge in the application of model-based reinforcement learning (MBRL) to real-world environments. To handle high-dimensional sensory inputs, existing approaches use representation learning to…

Machine Learning · Computer Science 2021-06-15 Tung Nguyen , Rui Shu , Tuan Pham , Hung Bui , Stefano Ermon

Time series data is essential in various applications, including climate modeling, healthcare monitoring, and financial analytics. Understanding the contextual information associated with real-world time series data is often essential for…

Artificial Intelligence · Computer Science 2025-03-11 Geon Lee , Wenchao Yu , Kijung Shin , Wei Cheng , Haifeng Chen

Large language models (LLMs) have emerged as promising tools for assisting in medical tasks, yet processing Electronic Health Records (EHRs) presents unique challenges due to their longitudinal nature. While LLMs' capabilities to perform…

Artificial Intelligence · Computer Science 2025-03-07 Hejie Cui , Alyssa Unell , Bowen Chen , Jason Alan Fries , Emily Alsentzer , Sanmi Koyejo , Nigam Shah

Representing continuous time is a critical and under-explored challenge in modeling temporal event sequences with large language models (LLMs). Various strategies like byte-level representations or calendar tokens have been proposed.…

Computation and Language · Computer Science 2026-05-12 Zefang Liu , Nam H. Nguyen , Yinzhu Quan , Shi-Xiong Zhang

Analyzing temporal developments is crucial for the accurate prognosis of many medical conditions. Temporal changes that occur over short time scales are key to assessing the health of physiological functions, such as the cardiac cycle.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Chengzhi Shen , Martin J. Menten , Hrvoje Bogunović , Ursula Schmidt-Erfurth , Hendrik Scholl , Sobha Sivaprasad , Andrew Lotery , Daniel Rueckert , Paul Hager , Robbie Holland

Clinical notes in Electronic Health Records (EHRs) capture rich temporal information on events, clinician reasoning, and lifestyle factors often missing from structured data. Leveraging them for predictive modeling can be impactful for…

Computation and Language · Computer Science 2026-05-08 Rochana Chaturvedi , Yue Zhou , Andrew D. Boyd , Brian T. Layden , Mudassir Rashid , Lu Cheng , Ali Cinar , Barbara Di Eugenio

Pre-trained Large Language Models (LLMs) encapsulate large amounts of knowledge and take enormous amounts of compute to train. We make use of this resource, together with the observation that LLMs are able to transfer knowledge and…

Machine Learning · Computer Science 2025-01-14 Malcolm L. Wolff , Shenghao Yang , Kari Torkkola , Michael W. Mahoney

Large language models (LLMs) excel at text generation, but their ability to handle clinical classification tasks involving structured data, such as time series, remains underexplored. In this work, we adapt instruction-tuned LLMs using…

Computation and Language · Computer Science 2025-09-18 Iyadh Ben Cheikh Larbi , Ajay Madhavan Ravichandran , Aljoscha Burchardt , Roland Roller

Clinical notes contain valuable, context-rich information, but their unstructured format introduces several challenges, including unintended biases (e.g., gender or racial bias), and poor generalization across clinical settings (e.g.,…

Computation and Language · Computer Science 2025-11-18 Karthikeyan K , Raghuveer Thirukovalluru , David Carlson

Traditional machine learning methods face two main challenges in dealing with healthcare predictive analytics tasks. First, the high-dimensional nature of healthcare data needs labor-intensive and time-consuming processes to select an…

Machine Learning · Computer Science 2022-09-16 Mohammad Amin Morid , Olivia R. Liu Sheng , Joseph Dunbar

Clinical natural language processing (NLP) models have shown promise for supporting hospital discharge planning by leveraging narrative clinical documentation. However, note-based models are particularly vulnerable to temporal and lexical…

Computation and Language · Computer Science 2026-02-20 Ha Na Cho , Sairam Sutari , Alexander Lopez , Hansen Bow , Kai Zheng

Tracking entities throughout a procedure described in a text is challenging due to the dynamic nature of the world described in the process. Firstly, we propose to formulate this task as a question answering problem. This enables us to use…

Computation and Language · Computer Science 2021-04-16 Hossein Rajaby Faghihi , Parisa Kordjamshidi

Recent advances in large language models (LLMs) have shown potential in clinical text summarization, but their ability to handle long patient trajectories with multi-modal data spread across time remains underexplored. This study…

Computation and Language · Computer Science 2025-09-08 Maya Kruse , Shiyue Hu , Nicholas Derby , Yifu Wu , Samantha Stonbraker , Bingsheng Yao , Dakuo Wang , Elizabeth Goldberg , Yanjun Gao

In recent times, Large Language Models (LLMs) have captured a global spotlight and revolutionized the field of Natural Language Processing. One of the factors attributed to the effectiveness of LLMs is the model architecture used for…

Machine Learning · Computer Science 2023-08-31 Oluwaseyi Ogunfowora , Homayoun Najjaran
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