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Discovering new drug molecules is a pivotal yet challenging process due to the near-infinitely large chemical space and notorious demands on time and resources. Numerous generative models have recently been introduced to accelerate the drug…

Computational Engineering, Finance, and Science · Computer Science 2025-12-23 Shitong Luo , Wenhao Gao , Zuofan Wu , Jian Peng , Connor W. Coley , Jianzhu Ma

A fundamental research goal for Explainable AI (XAI) is to build models that are capable of reasoning through the generation of natural language explanations. However, the methodologies to design and evaluate explanation-based inference…

Artificial Intelligence · Computer Science 2022-05-06 Marco Valentino , André Freitas

We present a novel approach to construction of a formal semantics for a programming language. Our approach, using a parametric denotational semantics, allows the semantics to be easily extended to support new language features, and…

Programming Languages · Computer Science 2018-12-04 In-Ho Yi

Grammatic is a tool for grammar definition and manipulation aimed to improve modularity and reuse of grammars and related development artifacts. It is independent from parsing technology and any other details of target system…

Programming Languages · Computer Science 2009-01-19 Andrey Breslav

We propose a novel approach to program synthesis, focusing on synthesizing database queries. At a high level, our proposed algorithm takes as input a sketch with soft constraints encoding user intent, and then iteratively interacts with the…

Programming Languages · Computer Science 2021-10-12 Osbert Bastani , Xin Zhang , Armando Solar-Lezama

We argue that existing definitions of interpretability are not actionable in that they fail to inform users about general, sound, and robust interpretable model design. This makes current interpretability research fundamentally ill-posed.…

Machine Learning · Computer Science 2025-08-04 Pietro Barbiero , Mateo Espinosa Zarlenga , Alberto Termine , Mateja Jamnik , Giuseppe Marra

Motivated by questions from program transformations, eight notions of isomorphisms between term rewriting systems are defined, analysed, and classified. The notions include global isomorphisms, where the renaming of variables and function…

Logic in Computer Science · Computer Science 2022-12-01 Michael Christian Fink Amores , David Sabel

Reaction-diffusion systems offer a powerful framework for understanding self-organized patterns in biological systems, yet controlling these patterns remains a significant challenge. As a consequence, we present a rigorous framework of…

Optimization and Control · Mathematics 2026-04-13 Mohamed Amine Ouchdiri , Hamza Faquir , Saad Benjelloun , Mohamed Adlene Maghenem , Irene Otero-Muras , Adnane Saoud

This note clarifies the concept of syntax and semantics and their relationships. Today, a lot of confusion arises from the fact that the word "semantics" is used in different meanings. We discuss a general approach at defining semantics…

Software Engineering · Computer Science 2014-09-25 Bernhard Rumpe

Relational databases play an important role in business, science, and more. However, many users cannot fully unleash the analytical power of relational databases, because they are not familiar with database languages such as SQL. Many…

Databases · Computer Science 2024-01-08 Yuan Tian , Zheng Zhang , Zheng Ning , Toby Jia-Jun Li , Jonathan K. Kummerfeld , Tianyi Zhang

The scattering of electromagnetic waves by resonant systems is determined by the excitation of quasinormal modes (QNMs), i.e., the eigenmodes of the system. This Review addresses three fundamental concepts in relation with the…

Quantum Physics · Physics 2022-03-02 C. Sauvan , T. Wu , R. Zarouf , E. A. Muljarov , P. Lalanne

Complex systems are composed of many particles or agents that move and interact with one another. The underlying mathematical framework to model many of these systems must incorporate the spatial transport of particles and their…

Statistical Mechanics · Physics 2026-02-09 Mauricio J. del Razo , Tommaso Lamma , Wout Merbis

A microscopic calculation of reaction cross sections for nucleon-nucleus scattering has been performed by explicitly coupling the elastic channel to all particle-hole excitations in the target and one-nucleon pickup channels. The…

Nuclear Theory · Physics 2011-12-26 G. P. A. Nobre , F. S. Dietrich , J. E. Escher , I. J. Thompson , M. Dupuis , J. Terasaki , J. Engel

Reaction diffusion systems describe the behaviour of dynamic, interacting, particulate systems. Quantum stochastic processes generalise Brownian motion and Poisson processes, having operator valued It\^{o} calculus machinery. Here it is…

Mathematical Physics · Physics 2023-05-31 Chris D Greenman

Chemical reaction mechanisms are the foundation of how chemists evaluate reactivity and feasibility, yet current Computer-Assisted Synthesis Planning (CASP) systems operate without this mechanistic reasoning. We introduce a computational…

Machine Learning · Computer Science 2026-04-20 Théo A. Neukomm , Zlatko Jončev , Philippe Schwaller

In this work, we present an application of Locally Interpretable Machine-Agnostic Explanations to 2-D chemical structures. Using this framework we are able to provide a structural interpretation for an existing black-box model for…

Machine Learning · Statistics 2016-11-23 Leanne S. Whitmore , Anthe George , Corey M. Hudson

This paper is centered on using chemical reaction as a computational metaphor for simultaneously solving problems. An artificial chemical reactor that can simultaneously solve instances of three unrelated problems was created. The reactor…

Emerging Technologies · Computer Science 2015-06-30 Jaderick P. Pabico

Starting from a microscopic approach, we develop a covariant formalism to describe a set of interacting gases. For that purpose, we model the collision term entering the Boltzmann equation for a class of interactions and then integrate this…

General Relativity and Quantum Cosmology · Physics 2009-10-31 Jean-Philippe Uzan

The need for systems to explain behavior to users has become more evident with the rise of complex technology like machine learning or self-adaptation. In general, the need for an explanation arises when the behavior of a system does not…

Software Engineering · Computer Science 2021-08-16 Mersedeh Sadeghi , Verena Klös , Andreas Vogelsang

Notions of guardedness serve to delineate admissible recursive definitions in various settings in a compositional manner. In recent work, we have introduced an axiomatic notion of guardedness in symmetric monoidal categories, which serves…

Logic in Computer Science · Computer Science 2021-05-25 Sergey Goncharov , Christoph Rauch , Lutz Schröder