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Differentiating between the two main subtypes of Inflammatory Bowel Disease (IBD): Crohns disease (CD) and ulcerative colitis (UC) is a persistent clinical challenge due to overlapping presentations. This study introduces a novel…

Genomics · Quantitative Biology 2026-01-14 Myles Joshua Toledo Tan , Maria Kapetanaki , Panayiotis V. Benos

Crohn's Disease (CD) and Ulcerative Colitis (UC) are the two main Inflammatory Bowel Disease (IBD) types. We developed deep learning models to identify histological disease features for both CD and UC using only endoscopic labels. We…

The Wireless Capsule Endoscopy (WCE) is becoming a popular way of screening gastrointestinal system diseases and cancer. However, the time-consuming process in inspecting WCE data limits its applications and increases the cost of…

Computer Vision and Pattern Recognition · Computer Science 2018-09-10 Xiaolu Zhang , Shiwan Zhao , Lingxi Xie

Inflammatory bowel diseases (IBD) are complex diseases in which the gut microbiota is attacked by the immune system of genetically predisposed subjects when they are exposed to yet unclear environmental factors. The complexity of this class…

Quantitative Methods · Quantitative Biology 2022-08-17 Mirko Hu , Guido Caldarelli , Tommaso Gili

International Classification of Diseases (ICD) is a globally recognized coding system that records diagnostic events during each patient encounter, providing a standardized data foundation for various clinical tasks. However, the irregular…

Artificial Intelligence · Computer Science 2026-05-28 Leo Y. Li-Han , Ellen L. Larson , Elizabeth B. Habermann , Cornelius A. Thiels , Hojjat Salehinejad

Due to its safety-critical property, the image-based diagnosis is desired to achieve robustness on out-of-distribution (OOD) samples. A natural way towards this goal is capturing only clinically disease-related features, which is composed…

Computer Vision and Pattern Recognition · Computer Science 2022-04-22 Churan Wang , Jing Li , Xinwei Sun , Fandong Zhang , Yizhou Yu , Yizhou Wang

Ulcerative colitis (UC) is one of the most common forms of inflammatory bowel disease (IBD) characterized by inflammation of the mucosal layer of the colon. Diagnosis of UC is based on clinical symptoms, and then confirmed based on…

Quantitative Methods · Quantitative Biology 2020-08-05 Hanieh Marvi Khorasani , Hamid Usefi , Lourdes Peña-Castillo

Geometric deep learning provides a principled and versatile manner for the integration of imaging and non-imaging modalities in the medical domain. Graph Convolutional Networks (GCNs) in particular have been explored on a wide variety of…

As the therapeutic target for Inflammatory Bowel Disease (IBD) shifts toward histologic remission, the accurate assessment of microscopic inflammation has become increasingly central for evaluating disease activity and response to…

Foot ulcer is a common complication of diabetes mellitus and, associated with substantial morbidity and mortality, remains a major risk factor for lower leg amputations. Extracting accurate morphological features from foot wounds is crucial…

Image and Video Processing · Electrical Eng. & Systems 2022-06-20 Amirreza Mahbod , Gerald Schaefer , Rupert Ecker , Isabella Ellinger

Gastrointestinal endoscopy is a medical procedure that utilizes a flexible tube equipped with a camera and other instruments to examine the digestive tract. This minimally invasive technique allows for diagnosing and managing various…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Pham Vu Hung , Nguyen Duy Manh , Nguyen Thi Oanh , Nguyen Thi Thuy , Dinh Viet Sang

Ulcerative Colitis (UC) is an incurable inflammatory bowel disease that leads to ulcers along the large intestine and rectum. The increase in the prevalence of UC coupled with gastrointestinal physician shortages stresses the healthcare…

Image and Video Processing · Electrical Eng. & Systems 2024-12-12 Venkat Margapuri

The tremendous boost in the next generation sequencing and in the omics technologies makes it possible to characterize human gut microbiome (the collective genomes of the microbial community that reside in our gastrointestinal tract). While…

Quantitative Methods · Quantitative Biology 2020-01-10 Hilal Hacilar , O. Ufuk Nalbantoglu , Oya Aran , Burcu Bakir-Gungor

The task of spatial clustering of transcriptomics data is of paramount importance. It enables the classification of tissue samples into diverse subpopulations of cells, which, in turn, facilitates the analysis of the biological functions of…

Machine Learning · Computer Science 2025-07-29 Mehrad Soltani , Luis Rueda

Developing computational tools for integrative analysis across multiple types of omics data has been of immense importance in cancer molecular biology and precision medicine research. While recent advancements have yielded integrative…

Deep convolutional neural networks(CNNs) have been successful for a wide range of computer vision tasks, including image classification. A specific area of the application lies in digital pathology for pattern recognition in the…

Image and Video Processing · Electrical Eng. & Systems 2020-08-10 Rasoul Sali , Sodiq Adewole , Lubaina Ehsan , Lee A. Denson , Paul Kelly , Beatrice C. Amadi , Lori Holtz , Syed Asad Ali , Sean R. Moore , Sana Syed , Donald E. Brown

The gut microbiome, crucial for human health, presents challenges in analyzing its complex metaomic data due to high dimensionality and sparsity. Traditional methods struggle to capture its intricate relationships. We investigate graph…

Machine Learning · Computer Science 2025-06-24 Christopher Irwin , Flavio Mignone , Stefania Montani , Luigi Portinale

Disease diagnosis on chest X-ray images is a challenging multi-label classification task. Previous works generally classify the diseases independently on the input image without considering any correlation among diseases. However, such…

Computer Vision and Pattern Recognition · Computer Science 2020-03-02 Daizong Liu , Shuangjie Xu , Pan Zhou , Kun He , Wei Wei , Zichuan Xu

Chronic wounds, including diabetic foot ulcers which affect up to one-third of people with diabetes, impose a substantial clinical and economic burden, with U.S. healthcare costs exceeding 25 billion dollars annually. Current wound…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Moses Kiprono

Grading inflammatory bowel disease (IBD) activity using standardized histopathological scoring systems remains challenging due to resource constraints and inter-observer variability. In this study, we developed a deep learning model to…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Amit Das , Tanmay Shukla , Naofumi Tomita , Ryland Richards , Laura Vidis , Bing Ren , Saeed Hassanpour
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