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Protein design is a technique to engineer proteins by modifying their sequence to obtain novel functionalities. In this method, amino acids in the sequence are permutated to find the low energy states satisfying the configuration. However,…

Quantitative Methods · Quantitative Biology 2023-05-10 Mohammad Hassan Khatami , Udson C. Mendes , Nathan Wiebe , Philip M. Kim

The description of gene interactions that constantly occur in the cellular environment is an extremely challenging task due to an immense number of degrees of freedom and incomplete knowledge about microscopic details. Hence, a…

Quantum Physics · Physics 2024-08-19 Mirko Rossini , Felix M. Weidner , Joachim Ankerhold , Hans A. Kestler

The 3-Satisfiability Problem (3-SAT) is a demanding combinatorial problem, of central importance among the non-deterministic polynomial (NP) complete problems, with applications in circuit design, artificial intelligence and logistics. Even…

Satisfiability (SAT) is a central problem in computer science, and advances in SAT-solving algorithms have a far-reaching impact across many fields. Recent works have proposed quantum SAT solvers based on Grover's algorithm, a quantum…

Quantum Physics · Physics 2026-04-21 Shang-Wei Lin , Ji-Qing Yan , Yean-Ru Chen , Zhe Hou , David Sanán

The use of Boolean Satisfiability (SAT) solver for hardware verification incurs exponential run-time in several instances. In this work we have proposed an efficient quantum SAT (qSAT) solver for equivalence checking of Boolean circuits…

Quantum Physics · Physics 2026-05-19 Abhoy Kole , Mohammed E. Djeridane , Lennart Weingarten , Kamalika Datta , Rolf Drechsler

Protein folding, which dictates the protein structure from its amino acid sequence, is half a century old problem of biology. The function of the protein correlates with its structure, emphasizing the need of understanding protein folding…

Quantum Physics · Physics 2025-01-03 Jaya Vasavi P , Soham Bopardikar , Avinash D , Ashwini K , Kalyan Dasgupta , Sanjib Senapati

The Boolean satisfiability problem (SAT) is of central importance in both theory and practice. Yet, most provable guarantees for quantum algorithms rely exclusively on Grover-type methods that cap the possible advantage at only quadratic…

Quantum Physics · Physics 2025-11-14 Franz J. Schreiber , Maximilian J. Kramer , Alexander Nietner , Jens Eisert

As a compact representation of joint probability distributions over a dependence graph of random variables, and a tool for modelling and reasoning in the presence of uncertainty, Bayesian networks are of great importance for artificial…

Quantum Physics · Physics 2020-10-06 Michael de Oliveira , Luis Soares Barbosa

In this paper, we analyse large random Boolean networks in terms of a constraint satisfaction problem. We first develop an algorithmic scheme which allows to prune simple logical cascades and under-determined variables, returning thereby…

Statistical Mechanics · Physics 2009-11-11 L. Correale , M. Leone , A. Pagnani , M. Weigt , R. Zecchina

Replication of DNA and synthesis of proteins are studied from the view-point of quantum database search. Identification of a base-pairing with a quantum query gives a natural (and first ever) explanation of why living organisms have 4…

Quantum Physics · Physics 2009-11-06 Apoorva Patel

We review enzymatic systems which involve biocatalytic reactions utilized for information processing (biocomputing). Extensive ongoing research in biocomputing, mimicking Boolean logic gates has been motivated by potential applications in…

Biological Physics · Physics 2010-10-12 Evgeny Katz , Vladimir Privman

Protein folding processes are a vital aspect of molecular biology that is hard to simulate with conventional computers. Quantum algorithms have been proven superior for certain problems and may help tackle this complex life science…

Quantum Physics · Physics 2024-09-11 Hanna Linn , Isak Brundin , Laura García-Álvarez , Göran Johansson

Grover's algorithm is a well-known unstructured quantum search algorithm run on quantum computers. It constructs an oracle and calls the oracle O($\sqrt N$) times to locate specific data out of N unsorted data. This represents a quadratic…

Computational Complexity · Computer Science 2023-12-18 Jehn-Ruey Jiang , Qiao-Yi Lin

Boolean satisfiability (SAT) solving is a fundamental problem in computer science. Finding efficient algorithms for SAT solving has broad implications in many areas of computer science and beyond. Quantum SAT solvers have been proposed in…

Quantum Physics · Physics 2023-08-08 Shang-Wei Lin , Tzu-Fan Wang , Yean-Ru Chen , Zhe Hou , David Sanán , Yon Shin Teo

This paper presents a complete algorithmic study of the decision Boolean Satisfiability Problem under the classical computation and quantum computation theories. The paper depicts deterministic and probabilistic algorithms, propositions of…

Computational Complexity · Computer Science 2016-02-22 Carlos Barrón-Romero

We develop a computation model for solving Boolean networks by implementing wires through quantum ground-mode computation and gates through identities following from angular momentum algebra and statistics. Gates are represented by…

Quantum Physics · Physics 2007-05-23 Giuseppe Castagnoli , David Ritz Finkelstein

Boolean Satisfiability problems are vital components in Electronic Design Automation, particularly within the Logic Equivalence Checking process. Currently, SAT solvers are employed for these problems and neural network is tried as…

Artificial Intelligence · Computer Science 2024-03-07 Tsz Ho Chan , Wenyi Xiao , Junhua Huang , Huiling Zhen , Guangji Tian , Mingxuan Yuan

Molecular docking is a critical computational strategy in drug design and discovery, but the complex diversity of biomolecular structures and flexible binding conformations create an enormous search space that challenges conventional…

Computational Physics · Physics 2025-03-27 Yihan He , Ming-Chun Hong , Qiming Ding , Chih-Sheng Lin , Chih-Ming Lai , Chao Fang , Xiao Gong , Tuo-Hung Hou , Gengchiau Liang

In this paper, it is demonstrated that the DNA-based algorithm [Ho et al. 2005] for solving an instance of the clique problem to any a graph G = (V, E) with n vertices and p edges and its complementary graph G1 = (V, E1) with n vertices and…

Data Structures and Algorithms · Computer Science 2009-05-14 Weng-Long Chang , Ting-Ting Ren , Mang Feng , Jun Luo , Kawuu Weicheng Lin , Minyi Guo , Lai Chin Lu

Bayesian network structure learning is an NP-hard problem that has been faced by a number of traditional approaches in recent decades. Currently, quantum technologies offer a wide range of advantages that can be exploited to solve…

Quantum Physics · Physics 2022-03-07 Vicente P. Soloviev , Concha Bielza , Pedro Larrañaga
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