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Biologically important molecules span a size range from very large biomacromolecules, such as proteins to small metabolite molecules. Consequently, spectroscopic techniques which can detect and characterize the structure of inherently…

Chiral near fields possessing enhanced asymmetry (superchirality), created by the interaction of light with (chiral) nanostructures, potentially provide a route to novel sensing and metrology technologies for biophysical applications.…

Chiroptical enantioselective sensing is gaining traction across various applications. However, intrinsic molecular chiroptical responses are weak, and existing amplification approaches add synthesis, manufacturing, or operational complexity…

The detection and discrimination of molecular chirality are essential for advancing pharmaceutical and biological applications. While nanophotonic platforms offer a route to enhance chiral light-matter interactions, existing device concepts…

Optics · Physics 2025-11-21 Zhongjun Jiang , Soyaib Sohag , You Zhou

Fine management of chiral processes on solid surfaces has progressed over the years, yet still faces the need for the controlled and selective production of advanced chiral materials. Here, we report on the use of enantiomerically enriched…

Molecular chirality detection and enantiomer discrimination are very important issues for many areas of science and technology, prompting intensive investigations via optical methods. However, these methods are hindered by the intrinsically…

Chiral discrimination that is efficient to tiny amounts of chiral substances, especially at the single-molecule level, is highly demanded. Here, we propose a single-shot nondestructive quantum sensing method addressing such an issue. Our…

Quantum Physics · Physics 2023-10-05 Chong Ye , Yifan Sun , Yong Li , Xiangdong Zhang

Chiral nanomaterials offer intriguing possibilities for novel electronic and chemical applications. Here, we report the discovery of an enantiomer-selective magnetoresistance effect in chiral gold nanocrystals. Based on precise control of…

Mesoscale and Nanoscale Physics · Physics 2025-03-03 Fengxia Wu , Ying Wang , Yufei Zhao , Zhenyu Yang , Yu Tian , Zuoti Xie , Wenxin Niu , Binghai Yan , Cunlan Guo

Chiral discrimination of enantiomeric biomolecules is vital in chemistry, biology, and medicine. Conventional methods, relying on circularly polarized light, face weak chiroptical signals and potential photodamage. Despite extensive efforts…

Quantum Physics · Physics 2026-01-21 Yiquan Yang , Xiaolong Hu , Wei Du , Shuhe Wu , Peiyu Yang , Guzhi Bao , Weiping Zhang

Resonance energy transfer between chiral molecules can be used to discriminate between different enantiomers. The transfer rate between chiral molecules consists of a non-discriminatory and discriminatory parts. We derive these two rate…

Quantum Physics · Physics 2023-03-29 Janine Christine Franz , Stefan Yoshi Buhmann , A. Salam

From the beginning of molecular theory, the interplay of chirality and magnetism has intrigued scientists. There is still the question if enantiospecific adsorption of chiral molecules occurs on magnetic surfaces. Enantiomer discrimination…

We propose a method to realize enantiodiscrimination of chiral molecules based on quantum correlation function in a driven cavity-molecule system, where the chiral molecule is coupled with a quantized cavity field and two classical light…

Quantum Physics · Physics 2022-08-12 Fen Zou , Yu-Yuan Chen , Bo Liu , Yong Li

Chirality discrimination is of a fundamental interest in biology, chemistry, and metamaterial studies. In optics, near-field plasmon-resonance spectroscopy with superchiral probing fields is effectively applicable for analyses of large…

Materials Science · Physics 2016-05-03 E. Hollander , E. O. Kamenetskii , R. Shavit

We discuss how tensorial observables, available in photoelectron angular distributions resulting from interaction between isotropic chiral samples and cross polarized $\omega$-$2\omega$ bichromatic fields, allow for chiral discrimination…

Atomic Physics · Physics 2022-06-28 Andres F. Ordonez , Olga Smirnova

The development of efficient techniques to distinguish mirror images of chiral molecules (enantiomers) is very important in both chemistry and physics. Enantiomers share most molecular properties except, for instance, the absorption of…

Chemical Physics · Physics 2023-07-11 Rosario R. Riso , Laura Grazioli , Enrico Ronca , Tommaso Giovannini , Henrik Koch

Molecular matter-wave interferometry enables novel strategies for manipulating the internal mechanical motion of complex molecules. Here, we show how chiral molecules can be prepared in a quantum superposition of two enantiomers by…

Quantum Physics · Physics 2021-09-22 Benjamin A. Stickler , Mira Diekmann , Robert Berger , Daqing Wang

This work presents a quantum-limited optomechanical sensing platform for real-time detection and discrimination of chiral molecules, based on a multilayer hybrid plasmonic-mechanical resonator. Leveraging quantum zero-point motion and…

Optics · Physics 2025-07-29 Giuseppina Simone

Mirror symmetry is among the most fundamental concepts of physics and its spontaneous breaking at the molecular level allows chiral molecules to exist in two enantiomers that are mirror images of each other. The majority of chiro-optical…

Optics · Physics 2021-09-29 Alessandro Ciattoni

Strong light-matter coupling in chiral cavities has been proposed as an effective way to selectively interact with an enantiomer that shares the same handedness as the cavity's chiral mode. We show that surface plasmons supported by a…

Chirality pervades natural processes from the atomic to the cosmic scales, crucially impacting molecular chemistry and pharmaceutics. Traditional chirality sensing methods face challenges in sensitivity and efficiency, prompting the quest…

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