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MLLMs MLLMs are beginning to appear in clinical workflows, but their ability to perform complex medical reasoning remains unclear. We present Med-CMR, a fine-grained Medical Complex Multimodal Reasoning benchmark. Med-CMR distinguishes from…

Large language models (LLMs) have rapidly advanced in clinical decision-making, yet the deployment of proprietary systems is hindered by privacy concerns and reliance on cloud-based infrastructure. Open-source alternatives allow local…

Computation and Language · Computer Science 2026-04-29 Alif Munim , Jun Ma , Omar Ibrahim , Alhusain Abdalla , Shuolin Yin , Leo Chen , Bo Wang

Causal reasoning is a core component of intelligence. Large language models (LLMs) have shown impressive capabilities in generating human-like text, raising questions about whether their responses reflect true understanding or statistical…

Artificial Intelligence · Computer Science 2025-06-09 Hanna M. Dettki , Brenden M. Lake , Charley M. Wu , Bob Rehder

Large language models (LLMs) are entering clinical workflows as decision support tools, yet how they respond to explicit patient value statements -- the core content of shared decision-making -- remains unmeasured. We conducted a factorial…

Computers and Society · Computer Science 2026-03-03 Sanjay Basu

Large Language Models (LLMs) have attained human-level accuracy on medical question-answer (QA) benchmarks. However, their limitations in navigating open-ended clinical scenarios have recently been shown, raising concerns about the…

Computation and Language · Computer Science 2025-11-13 Jonathan Kim , Anna Podlasek , Kie Shidara , Feng Liu , Ahmed Alaa , Danilo Bernardo

Large Language Models (LLMs) have shown impressive performance on a range of educational tasks, but are still understudied for their potential to solve mathematical problems. In this study, we compare three prominent LLMs, including GPT-4o,…

Artificial Intelligence · Computer Science 2025-07-01 Ruonan Wang , Runxi Wang , Yunwen Shen , Chengfeng Wu , Qinglin Zhou , Rohitash Chandra

This study presents a comparative evaluation of ten state-of-the-art large language models (LLMs) applied to unstructured text categorization using the Interactive Advertising Bureau (IAB) 2.2 hierarchical taxonomy. The analysis employed a…

Computation and Language · Computer Science 2025-10-17 Ariel Kamen

Reasoning-enabled LLMs perform strongly on medical reasoning benchmarks, but it remains unclear whether these gains transfer to structured clinical documentation; we investigate this question using SOAP note generation from clinical…

Computation and Language · Computer Science 2026-05-26 Faizan Faisal

Large Language Models (LLMs) have fundamentally transformed approaches to Natural Language Processing (NLP) tasks across diverse domains. In healthcare, accurate and cost-efficient text classification is crucial, whether for clinical notes…

Computation and Language · Computer Science 2026-02-16 Hajar Sakai , Sarah S. Lam

Strategic model selection and reasoning settings are more effective than ensembling for optimizing automated scoring with large language models (LLMs). We examined self-consistency (intra-model majority voting) and reasoning effort for…

Computers and Society · Computer Science 2026-05-01 Scott Frohn

This study introduces a framework for evaluating consistency in large language model (LLM) binary text classification, addressing the lack of established reliability assessment methods. Adapting psychometric principles, we determine sample…

Computation and Language · Computer Science 2025-12-23 Fadel M. Megahed , Ying-Ju Chen , L. Allision Jones-Farmer , Younghwa Lee , Jiawei Brooke Wang , Inez M. Zwetsloot

This study evaluates the performance of several Large Language Models (LLMs) on MedRedQA, a dataset of consumer-based medical questions and answers by verified experts extracted from the AskDocs subreddit. While LLMs have shown proficiency…

Computation and Language · Computer Science 2025-01-03 Moaiz Abrar , Yusuf Sermet , Ibrahim Demir

Background: Large language models (LLMs) such as OpenAI's GPT-4 or Google's PaLM 2 are proposed as viable diagnostic support tools or even spoken of as replacements for "curbside consults". However, even LLMs specifically trained on medical…

Artificial Intelligence · Computer Science 2024-10-21 Gioele Barabucci , Victor Shia , Eugene Chu , Benjamin Harack , Nathan Fu

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Previous research has reported that large language models (LLMs) demonstrate poor performance on the Chartered Financial Analyst (CFA) exams. However, recent reasoning models have achieved strong results on graduate-level academic and…

Artificial Intelligence · Computer Science 2025-12-10 Jaisal Patel , Yunzhe Chen , Kaiwen He , Keyi Wang , David Li , Kairong Xiao , Xiao-Yang Liu

Clinical reasoning agents based on large language models (LLMs) aim to automate tasks such as intensive care unit (ICU) monitoring and patient state tracking from electronic health records (EHRs). Existing systems typically rely on manually…

Artificial Intelligence · Computer Science 2026-05-12 Timothy Ossowski , Xinchi Liu , Danyal Maqbool , Vaibhav Dhanuka , Sheng Zhang , Hoifung Poon , Majid Afshar , Tyler Bradshaw , Junjie Hu

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Case-based reasoning is a cornerstone of U.S. legal practice, requiring professionals to argue about a current case by drawing analogies to and distinguishing from past precedents. While Large Language Models (LLMs) have shown remarkable…

Computation and Language · Computer Science 2026-01-21 Li Zhang , Matthias Grabmair , Morgan Gray , Kevin Ashley