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We introduce a method for solving combinatorial optimization problems on digital quantum computers, where we incorporate auxiliary counterdiabatic (CD) terms into the adiabatic Hamiltonian, while integrating bias terms derived from an…

Radiation therapy treatment planning can be viewed as an iterative hyperparameter tuning process to balance conflicting clinical goals. In this work, we investigated the performance of modern Bayesian Optimization (BO) methods on automated…

Medical Physics · Physics 2023-02-15 Qingying Wang , Ruoxi Wang , Jiacheng Liu , Fan Jiang , Haizhen Yue , Yi Du , Hao Wu

We present a detailed study of portfolio optimization using different versions of the quantum approximate optimization algorithm (QAOA). For a given list of assets, the portfolio optimization problem is formulated as quadratic binary…

We present a novel quantum optimization-based route compression technique that significantly reduces storage requirements compared to conventional methods. Route optimization systems face critical challenges in efficiently storing selected…

Quantum Physics · Physics 2025-04-07 Shunsuke Sotobayashi , Yuichiro Minato , Takao Tomono

A quantum-inspired optimization approach is proposed to study the portfolio optimization aimed at selecting an optimal mix of assets based on the risk-return trade-off to achieve the desired goal in investment. By integrating conventional…

Portfolio Management · Quantitative Finance 2024-11-15 Ying-Chang Lu , Chao-Ming Fu , Lien-Po Yu , Yen-Jui Chang , Ching-Ray Chang

Quantum computing exploits basic quantum phenomena such as state superposition and entanglement to perform computations. The Quantum Approximate Optimization Algorithm (QAOA) is arguably one of the leading quantum algorithms that can…

Machine Learning · Computer Science 2022-06-16 Sami Khairy , Ruslan Shaydulin , Lukasz Cincio , Yuri Alexeev , Prasanna Balaprakash

Combinatorial optimization problems are pivotal across many fields. Among these, Quadratic Unconstrained Binary Optimization (QUBO) problems, central to fields like portfolio optimization, network design, and computational biology, are…

Optimization and Control · Mathematics 2024-06-07 Yuhan Huang , Siyuan Jin , Yichi Zhang , Ling Pan , Qiming Shao

Quantum approximate optimization is one of the promising candidates for useful quantum computation, particularly in the context of finding approximate solutions to Quadratic Unconstrained Binary Optimization (QUBO) problems. However, the…

In this work, we introduce a novel Quadratic Binary Optimization (QBO) framework for training a quantized neural network. The framework enables the use of arbitrary activation and loss functions through spline interpolation, while Forward…

Machine Learning · Computer Science 2025-12-09 Wenxin Li , Chuan Wang , Hongdong Zhu , Qi Gao , Yin Ma , Hai Wei , Kai Wen

To date, research in quantum computation promises potential for outperforming classical heuristics in combinatorial optimization. However, when aiming at provable optimality, one has to rely on classical exact methods like integer…

Quantum Physics · Physics 2025-03-13 Friedrich Wagner , Jonas Nüßlein , Frauke Liers

Leveraging quantum computers for optimization problems holds promise across various application domains. Nevertheless, utilizing respective quantum computing solvers requires describing the optimization problem according to the Quadratic…

Quantum Physics · Physics 2025-10-15 Deborah Volpe , Nils Quetschlich , Mariagrazia Graziano , Giovanna Turvani , Robert Wille

High error rates and limited fidelity of quantum gates in near-term quantum devices are the central obstacles to successful execution of the Quantum Approximate Optimization Algorithm (QAOA). In this paper we introduce an…

Quantum Physics · Physics 2022-06-16 Ruslan Shaydulin , Alexey Galda

The Quadratic Unconstrained Binary Optimization problem (QUBO) has become a unifying model for representing a wide range of combinatorial optimization problems, and for linking a variety of disciplines that face these problems. A new class…

Artificial Intelligence · Computer Science 2017-05-30 Mark Lewis , Fred Glover

Bayesian network structure learning is an NP-hard problem that has been faced by a number of traditional approaches in recent decades. Currently, quantum technologies offer a wide range of advantages that can be exploited to solve…

Quantum Physics · Physics 2022-03-07 Vicente P. Soloviev , Concha Bielza , Pedro Larrañaga

Binary optimisation tasks are ubiquitous in areas ranging from logistics to cryptography. The exponential complexity of such problems means that the performance of traditional computational methods decreases rapidly with increasing problem…

Quantum computing is poised to transform the financial industry, yet its advantages over traditional methods have not been evidenced. As this technology rapidly evolves, benchmarking is essential to fairly evaluate and compare different…

Optimization and Control · Mathematics 2025-02-11 Ying Chen , Thorsten Koch , Hanqiu Peng , Hongrui Zhang

Bayesian optimization (BO) is a principled approach to molecular design tasks. In this paper we explain three pitfalls of BO which can cause poor empirical performance: an incorrect prior width, over-smoothing, and inadequate acquisition…

Machine Learning · Computer Science 2024-07-26 Austin Tripp , José Miguel Hernández-Lobato

While the ultimate goal of solving computationally intractable problems is to find a provably optimal solutions, practical constraints of real-world scenarios often necessitate focusing on efficiently obtaining high-quality, near-optimal…

Quantum Physics · Physics 2025-04-23 Prashanti Priya Angara , Emily Martins , Ulrike Stege , Hausi Müller

We propose a hybrid quantum-classical approximate optimization algorithm for photonic quantum computing, specifically tailored for addressing continuous-variable optimization problems. Inspired by counterdiabatic protocols, our algorithm…

Quantum Physics · Physics 2024-10-03 Pranav Chandarana , Koushik Paul , Mikel Garcia-de-Andoin , Yue Ban , Mikel Sanz , Xi Chen

The increasing complexity of industrial scheduling and transport routing problems motivates the study of alternative optimization formulations and computational paradigms. In this work, we study how higher-order unconstrained binary…

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