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Brain connectomics is still largely dominated by pairwise-based models, such as graphs, which cannot represent circulatory or higher-order functional interactions. In this paper, we propose a multimodal framework based on Topological Signal…

Neurons and Cognition · Quantitative Biology 2026-04-01 Breno C. Bispo , Stefania Sardellitti , Juliano B. Lima , Fernando A. N. Santos

Many modern datasets are large and carry complex structural relationships. Graph-based methods have traditionally been used to represent networked data, modeling individual elements as nodes and pairwise interactions as edges. Furthermore,…

Signal Processing · Electrical Eng. & Systems 2026-05-25 Flavia Petruso , Maria Giulia Preti , Dimitri Van De Ville

To understand collective network behavior in the complex human brain, pairwise correlation networks alone are insufficient for capturing the high-order interactions that extend beyond pairwise interactions and play a crucial role in brain…

Neurons and Cognition · Quantitative Biology 2025-07-01 Qiang Li , Jingyu Liu , Vince D. Calhoun

The human brain is a complex system defined by multi-way, higher-order interactions invisible to traditional pairwise network models. Although a diverse array of analytical methods has been developed to address this shortcoming, the field…

Quantitative Methods · Quantitative Biology 2025-11-11 Mohamma Reza Salehi , Ali BashirGonbadi , Hamid Soltanian-Zadeh

The Topological Signal Processing (TSP) framework has been recently developed to analyze signals defined over simplicial complexes, i.e. topological spaces represented by finite sets of elements that are closed under inclusion of subsets…

Signal Processing · Electrical Eng. & Systems 2021-12-14 Stefania Sardellitti , Sergio Barbarossa , Lucia Testa

The brain's complex functionality emerges from network interactions that go beyond dyadic connections, with higher-order interactions significantly contributing to this complexity. One method of capturing higher-order interactions is…

Neurons and Cognition · Quantitative Biology 2024-06-11 Behdad Khodabandehloo , Payam Jannatdoust , Babak Nadjar Araabi

Understanding the common topological characteristics of the human brain network across a population is central to understanding brain functions. The abstraction of human connectome as a graph has been pivotal in gaining insights on the…

Quantitative Methods · Quantitative Biology 2023-04-26 Soumya Das , D. Vijay Anand , Moo K. Chung

Networked systems display complex patterns of interactions between a large number of components. In physical networks, these interactions often occur along structural connections that link components in a hard-wired connection topology,…

Neurons and Cognition · Quantitative Biology 2018-04-03 Jason Kim , Jonathan M. Soffer , Ari E. Kahn , Jean M. Vettel , Fabio Pasqualetti , Danielle S. Bassett

We present a novel topological framework for analyzing functional brain signals using time-frequency analysis. By integrating persistent homology with time-frequency representations, we capture multi-scale topological features that…

Neurons and Cognition · Quantitative Biology 2025-04-23 Moo K. Chung , Aaron F. Struck

Several data-driven approaches based on information theory have been proposed for analyzing high-order interactions involving three or more components of a network system. Most of these methods are defined only in the time domain and rely…

Applications · Statistics 2025-03-18 Yuri Antonacci , Chiara Bara' , Laura Sparacino , Gorana Mijatovic , Ludovico Minati , Luca Faes

The goal of this paper is to establish the fundamental tools to analyze signals defined over a topological space, i.e. a set of points along with a set of neighborhood relations. This setup does not require the definition of a metric and…

Signal Processing · Electrical Eng. & Systems 2020-10-28 Sergio Barbarossa , Stefania Sardellitti

Modern neuroimaging techniques provide us with unique views on brain structure and function; i.e., how the brain is wired, and where and when activity takes place. Data acquired using these techniques can be analyzed in terms of its network…

Image and Video Processing · Electrical Eng. & Systems 2018-01-31 Weiyu Huang , Thomas A. W. Bolton , John D. Medaglia , Danielle S. Bassett , Alejandro Ribeiro , Dimitri Van De Ville

Topology identification and inference of processes evolving over graphs arise in timely applications involving brain, transportation, financial, power, as well as social and information networks. This chapter provides an overview of graph…

Signal Processing · Electrical Eng. & Systems 2025-12-12 Gonzalo Mateos , Yanning Shen , Georgios B. Giannakis , Ananthram Swami

Higher-order networks have so far been considered primarily in the context of studying the structure of complex systems, i.e., the higher-order or multi-way relations connecting the constituent entities. More recently, a number of studies…

Signal Processing · Electrical Eng. & Systems 2022-02-03 Michael T. Schaub , Jean-Baptiste Seby , Florian Frantzen , T. Mitchell Roddenberry , Yu Zhu , Santiago Segarra

Developing methods to process irregularly structured data is crucial in applications like gene-regulatory, brain, power, and socioeconomic networks. Graphs have been the go-to algebraic tool for modeling the structure via nodes and edges…

Signal Processing · Electrical Eng. & Systems 2025-02-17 Elvin Isufi , Geert Leus , Baltasar Beferull-Lozano , Sergio Barbarossa , Paolo Di Lorenzo

Traditional functional connectivity based on functional magnetic resonance imaging (fMRI) can only capture pairwise interactions between brain regions. Hypergraphs, which reveal high-order relationships among multiple brain regions, have…

Neurons and Cognition · Quantitative Biology 2025-05-20 Wenqi Hu , Xuerui Su , Guanliang Li , Yidi Pan , Aijing Lin

The irreducible complexity of natural phenomena has led Graph Neural Networks to be employed as a standard model to perform representation learning tasks on graph-structured data. While their capacity to capture local and global patterns is…

Machine Learning · Computer Science 2024-02-13 Lorenzo Giusti

The study of irreducible higher-order interactions has become a core topic of study in complex systems. Two of the most well-developed frameworks, topological data analysis and multivariate information theory, aim to provide formal tools…

Information Theory · Computer Science 2025-04-15 Thomas F. Varley , Pedro A. M. Mediano , Alice Patania , Josh Bongard

Accurately characterizing higher-order interactions of brain regions and extracting interpretable organizational patterns from Functional Magnetic Resonance Imaging data is crucial for brain disease diagnosis. Current graph-based deep…

Neurons and Cognition · Quantitative Biology 2026-03-16 Dengyi Zhao , Zhiheng Zhou , Guiying Yan , Dongxiao Yu , Xingqin Qi

The brain's spatial orientation system uses different neuron ensembles to aid in environment-based navigation. Two of the ways brains encode spatial information is through head direction cells and grid cells. Brains use head direction cells…

Neural and Evolutionary Computing · Computer Science 2023-09-07 Edward C. Mitchell , Brittany Story , David Boothe , Piotr J. Franaszczuk , Vasileios Maroulas
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