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Large language models (LLMs) have revolutionized medical reasoning tasks, yet single-agent systems often falter on complex, interdisciplinary problems requiring robust handling of uncertainty and conflicting evidence. Multi-agent systems…

Artificial Intelligence · Computer Science 2026-05-29 Xiaoyang Wang , Christopher C. Yang

With the rapid progress of large language models (LLMs), LLM-powered multi-agent systems (MAS) are drawing increasing interest across academia and industry. However, many current MAS frameworks struggle with reliability and scalability,…

Multiagent Systems · Computer Science 2025-11-04 Yang Li , Siqi Ping , Xiyu Chen , Xiaojian Qi , Zigan Wang , Ye Luo , Xiaowei Zhang

Multi-agent systems (MAS) built on large language models (LLMs) offer a promising path toward solving complex, real-world tasks that single-agent systems often struggle to manage. While recent advancements in test-time scaling (TTS) have…

Artificial Intelligence · Computer Science 2025-08-20 Can Jin , Hongwu Peng , Qixin Zhang , Yujin Tang , Dimitris N. Metaxas , Tong Che

Data marketplaces, which mediate the purchase and exchange of data from third parties, have attracted growing attention for reducing the cost and effort of data collection while enabling the trading of diverse datasets. However, a…

Multiagent Systems · Computer Science 2025-11-18 Jun Sashihara , Yukihisa Fujita , Kota Nakamura , Masahiro Kuwahara , Teruaki Hayashi

Malicious agents pose significant threats to the reliability and decision-making capabilities of Multi-Agent Systems (MAS) powered by Large Language Models (LLMs). Existing defenses often fall short due to reactive designs or centralized…

Cryptography and Security · Computer Science 2026-04-03 Yang Feng , Xudong Pan

Therapy recommendation for chronic patients with multimorbidity is challenging due to risks of treatment conflicts. Existing decision support systems face scalability limitations. Inspired by the way in which general practitioners (GP)…

Artificial Intelligence · Computer Science 2025-07-16 Yicong Wu , Ting Chen , Irit Hochberg , Zhoujian Sun , Ruth Edry , Zhengxing Huang , Mor Peleg

Mobile autonomous system (MAS) becomes pervasive especially in the vehicular and robotic networks. Multiple heterogeneous MAS networks can be integrated together as a multi-layer MAS network to offer holistic services. The network…

Systems and Control · Electrical Eng. & Systems 2019-12-10 Juntao Chen , Quanyan Zhu

While multi-agent systems (MAS) have demonstrated superior performance over single-agent approaches in complex reasoning tasks, they often suffer from significant computational inefficiencies. Existing frameworks typically deploy large…

Artificial Intelligence · Computer Science 2026-01-27 Jingbo Wang , Sendong Zhao , Jiatong Liu , Haochun Wang , Wanting Li , Bing Qin , Ting Liu

Large Language Model-based Multi-Agent Systems (MASs) have emerged as a powerful paradigm for tackling complex tasks through collaborative intelligence. However, the topology of these systems--how agents in MASs should be configured,…

Multiagent Systems · Computer Science 2025-10-20 Jiaxi Yang , Mengqi Zhang , Yiqiao Jin , Hao Chen , Qingsong Wen , Lu Lin , Yi He , Srijan Kumar , Weijie Xu , James Evans , Jindong Wang

Multi-agent systems powered by Large Language Models (LLM-MAS) have demonstrated remarkable capabilities in collaborative problem-solving. However, their deployment also introduces new security risks. Existing research on LLM-based agents…

Multiagent Systems · Computer Science 2025-10-07 Yizhe Xie , Congcong Zhu , Xinyue Zhang , Tianqing Zhu , Dayong Ye , Minghao Wang , Chi Liu

Recent interest in Multi-Agent Systems of Large Language Models (MAS LLMs) has led to an increase in frameworks leveraging multiple LLMs to tackle complex tasks. However, much of this literature appropriates the terminology of MAS without…

Recent surges in LLM-driven intelligent systems largely overlook decades of foundational multi-agent systems (MAS) research, resulting in frameworks with critical limitations such as centralization and inadequate trust and communication…

Multiagent Systems · Computer Science 2025-10-22 Michael J. Wooldridge , Attila Bagoly , Jonathan J. Ward , Emanuele La Malfa , Gabriel Paludo Licks

Agentic AI applications increasingly rely on multiple agents with distinct roles, specialized tools, and access to memory layers to solve complex tasks -- closely resembling service-oriented architectures. Yet, in the rapid evolving…

Software Engineering · Computer Science 2025-10-15 Alessandro Cornacchia , Vaastav Anand , Muhammad Bilal , Zafar Qazi , Marco Canini

High-dimensional decision-making tasks, such as business partner selection, involve evaluating large candidate pools with heterogeneous numerical, categorical, and textual features. While large language models (LLMs) offer strong in-context…

Multiagent Systems · Computer Science 2025-11-03 Lingyao Li , Haolun Wu , Zhenkun Li , Jiabei Hu , Yu Wang , Xiaoshan Huang , Wenyue Hua , Wenqian Wang

The transition to open, distributed Multi-Agent Systems (MAS) promises scalable intelligence but introduces a non-trivial tension: maximizing global efficiency requires cooperative, resource-aware scheduling, yet autonomous agents may be…

Networking and Internet Architecture · Computer Science 2026-03-19 Hongze Liu , Chang Guo , Yingzeng Li , Mengru Wang , Jiong Lou , Shijing Yuan , Hefeng Zhou , Chentao Wu , Jie LI

This paper explores multi-agent systems and identify challenges that remain inadequately addressed. By leveraging the diverse capabilities and roles of individual agents, multi-agent systems can tackle complex tasks through agent…

Multiagent Systems · Computer Science 2026-01-29 Shanshan Han , Qifan Zhang , Weizhao Jin , Zhaozhuo Xu

Large language model (LLM)-based multi-agent systems have emerged as a powerful paradigm for enabling autonomous agents to solve complex tasks. As these systems scale in complexity, cost becomes an important consideration for practical…

Multiagent Systems · Computer Science 2025-11-27 Liming Yang , Junyu Luo , Xuanzhe Liu , Yiling Lou , Zhenpeng Chen

Multi-agent systems powered by large language models exhibit strong capabilities in collaborative problem-solving. However, these systems suffer from substantial knowledge redundancy. Agents duplicate efforts in retrieval and reasoning…

Graphics · Computer Science 2026-02-27 Heng Zhang , Yuling Shi , Xiaodong Gu , Haochen You , Zijian Zhang , Lubin Gan , Yilei Yuan , Jin Huang

The design space of agentic AI inference spans two extremes: frontier large language models (LLMs), typically hosted in the cloud and offering strong performance across a wide range of tasks at substantially high cost, and more…

Multiagent Systems · Computer Science 2026-05-29 Corrado Rainone , Davide Belli , Bence Major , Arash Behboodi

Multi-Agent Systems (MAS) with Large Language Model (LLM)-powered agents are gaining attention, yet fewer studies explore their team dynamics. Inspired by human team science, we propose a multi-agent framework to examine core aspects of…

Computation and Language · Computer Science 2025-10-13 Rasika Muralidharan , Haewoon Kwak , Jisun An