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As artificial intelligence (AI) becomes increasingly embedded in healthcare delivery, this chapter explores the critical aspects of developing reliable and ethical Clinical Decision Support Systems (CDSS). Beginning with the fundamental…

Artificial Intelligence · Computer Science 2025-02-18 Muhammet Alkan , Idris Zakariyya , Samuel Leighton , Kaushik Bhargav Sivangi , Christos Anagnostopoulos , Fani Deligianni

AI systems are assisting humans with increasingly diverse intellectual tasks but are still prone to mistakes. Humans are over-reliant on this assistance if they trust AI-generated advice, even though they would make a better decision on…

Computers and Society · Computer Science 2024-12-02 Rosco Hunter , Richard Moulange , Jamie Bernardi , Merlin Stein

Artificial Intelligence (AI) has demonstrated potential in healthcare, particularly in enhancing diagnostic accuracy and decision-making through Clinical Decision Support Systems (CDSSs). However, the successful implementation of these…

Human-Computer Interaction · Computer Science 2025-01-29 Olya Rezaeian , Alparslan Emrah Bayrak , Onur Asan

Clinical decision support systems (CDSS) augmented with artificial intelligence (AI) models are emerging as potentially valuable tools in healthcare. Despite their promise, the development and implementation of these systems typically…

Human-Computer Interaction · Computer Science 2023-03-08 Grace Golden , Christina Popescu , Sonia Israel , Kelly Perlman , Caitrin Armstrong , Robert Fratila , Myriam Tanguay-Sela , David Benrimoh

Artificial intelligence (AI) systems are deployed as collaborators in human decision-making. Yet, evaluation practices focus primarily on model accuracy rather than whether human-AI teams are prepared to collaborate safely and effectively.…

Human-Computer Interaction · Computer Science 2026-03-20 Min Hun Lee

In AI-assisted decision-making, it is critical for human decision-makers to know when to trust AI and when to trust themselves. However, prior studies calibrated human trust only based on AI confidence indicating AI's correctness likelihood…

Human-Computer Interaction · Computer Science 2023-01-18 Shuai Ma , Ying Lei , Xinru Wang , Chengbo Zheng , Chuhan Shi , Ming Yin , Xiaojuan Ma

A growing body of research has explored how to support humans in making better use of AI-based decision support, including via training and onboarding. Existing research has focused on decision-making tasks where it is possible to evaluate…

Human-Computer Interaction · Computer Science 2023-08-31 Anna Kawakami , Luke Guerdan , Yanghuidi Cheng , Matthew Lee , Scott Carter , Nikos Arechiga , Kate Glazko , Haiyi Zhu , Kenneth Holstein

While human-AI decision-making research has primarily used trust measurements to assess the practical usage of AI systems by their end-users, recent empirical evidence suggests that trust measurements do not inform users' appropriate…

Human-Computer Interaction · Computer Science 2026-04-28 Muhammad Raees , Konstantinos Papangelis

As AI systems demonstrate increasingly strong predictive performance, their adoption has grown in numerous domains. However, in high-stakes domains such as criminal justice and healthcare, full automation is often not desirable due to…

Artificial Intelligence · Computer Science 2021-12-23 Vivian Lai , Chacha Chen , Q. Vera Liao , Alison Smith-Renner , Chenhao Tan

AI-based decision support tools (ADS) are increasingly used to augment human decision-making in high-stakes, social contexts. As public sector agencies begin to adopt ADS, it is critical that we understand workers' experiences with these…

A profound gap persists between artificial intelligence (AI) and clinical practice in medicine, primarily due to the lack of rigorous and cost-effective evaluation methodologies. State-of-the-art and state-of-the-practice AI model…

Artificial intelligence (AI) is increasingly being considered to assist human decision-making in high-stake domains (e.g. health). However, researchers have discussed an issue that humans can over-rely on wrong suggestions of the AI model…

Human-Computer Interaction · Computer Science 2023-08-09 Min Hun Lee , Chong Jun Chew

The use of artificial intelligence (AI) in working environments with individuals, known as Human-AI Collaboration (HAIC), has become essential in a variety of domains, boosting decision-making, efficiency, and innovation. Despite HAIC's…

Human-Computer Interaction · Computer Science 2025-03-10 George Fragiadakis , Christos Diou , George Kousiouris , Mara Nikolaidou

Although artificial intelligence (AI) shows growing promise for mental health care, current approaches to evaluating AI tools in this domain remain fragmented and poorly aligned with clinical practice, social context, and first-hand user…

Many important decisions in daily life are made with the help of advisors, e.g., decisions about medical treatments or financial investments. Whereas in the past, advice has often been received from human experts, friends, or family,…

Human-Computer Interaction · Computer Science 2022-04-15 Max Schemmer , Patrick Hemmer , Niklas Kühl , Carina Benz , Gerhard Satzger

Recent developments in Artificial Intelligence (AI) have fueled the emergence of human-AI collaboration, a setting where AI is a coequal partner. Especially in clinical decision-making, it has the potential to improve treatment quality by…

Human-Computer Interaction · Computer Science 2022-04-21 Patrick Hemmer , Max Schemmer , Lara Riefle , Nico Rosellen , Michael Vössing , Niklas Kühl

As AI systems become increasingly capable and influential, ensuring their alignment with human values, preferences, and goals has become a critical research focus. Current alignment methods primarily focus on designing algorithms and loss…

Computation and Language · Computer Science 2025-05-02 Min-Hsuan Yeh , Jeffrey Wang , Xuefeng Du , Seongheon Park , Leitian Tao , Shawn Im , Yixuan Li

Artificial intelligence (AI) systems are increasingly integrated into healthcare and pharmacy workflows, supporting tasks such as medication recommendations, dosage determination, and drug interaction detection. While these systems often…

Artificial Intelligence · Computer Science 2026-05-21 Khalid Adnan Alsayed

Artificial intelligence (AI) in healthcare has the potential to improve patient outcomes, but clinician acceptance remains a critical barrier. We developed a novel decision support interface that provides interpretable treatment…

Human-Computer Interaction · Computer Science 2023-02-02 Venkatesh Sivaraman , Leigh A. Bukowski , Joel Levin , Jeremy M. Kahn , Adam Perer

Artificial intelligence (AI) is rapidly advancing in healthcare, enhancing the efficiency and effectiveness of services across various specialties, including cardiology, ophthalmology, dermatology, emergency medicine, etc. AI applications…

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