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Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the…

Medical Physics · Physics 2023-07-11 Guo-Yang Li , Xu Feng , Seok-Hyun Yun

The mechanical properties of arterial walls are critical for maintaining vascular function under pulsatile pressure and are closely linked to the development of cardiovascular diseases. Despite advances in imaging and elastography,…

Biological Physics · Physics 2025-07-29 Yuxuan Jiang , Guo-Yang Li , Ruizhi Wang , Xu Feng , Yanhang Zhang , Seok-Hyun Yun

Mechanical properties of tissue provide valuable information for identifying lesions. One approach to obtain quantitative estimates of elastic properties is shear wave elastography with optical coherence elastography (OCE). However, given…

Image and Video Processing · Electrical Eng. & Systems 2020-04-30 Maximilian Neidhardt , Marcel Bengs , Sarah Latus , Matthias Schlüter , Thore Saathoff , Alexander Schlaefer

Traveling-wave optical coherence elastography (OCE) is a promising technique to measure the stiffness of biological tissues. While OCE has been applied to relatively homogeneous samples, tissues with significantly varying elasticity through…

Medical Physics · Physics 2022-01-31 Xu Feng , Guo-Yang Li , Antoine Ramier , Amira M. Eltony , Seok-Hyun Yun

Elasticity is a fundamental cellular property that is related to the anatomy, functionality and pathological state of cells and tissues. However, current techniques based on cell deformation, atomic force microscopy or Brillouin scattering…

Robot-assisted surgery has advantages compared to conventional laparoscopic procedures, e.g., precise movement of the surgical instruments, improved dexterity, and high-resolution visualization of the surgical field. However, mechanical…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Maximilian Neidhardt , Robin Mieling , Sarah Latus , Martin Fischer , Tobias Maurer , Alexander Schlaefer

Dynamic optical coherence elastography (OCE) tracks mechanical wave propagation in the subsurface region of tissue to image its shear modulus. For bulk shear waves, the lateral resolution of the reconstructed modulus map (i.e.,…

Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise…

Instrumentation and Detectors · Physics 2021-04-07 Nichaluk Leartprapun , Rishyashring R. Iyer , Gavrielle R. Untracht , Jeffrey A. Mulligan , Steven G. Adie

The distinction between malignant and benign tumors is essential to the treatment of cancer. The tissue's elasticity can be used as an indicator for the required tissue characterization. Optical coherence elastography (OCE) probes have been…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Robin Mieling , Johanna Sprenger , Sarah Latus , Lennart Bargsten , Alexander Schlaefer

This article describes a novel quasi-real time system for quantitative and volumetric measurement of tissue elasticity in the prostate. Tissue elasticity is computed by using a local frequency estimator to measure the three dimensional…

Visualizing elastic waves by noninvasive imaging has been useful for analyzing the mechanical properties of materials and tissues. However, the maximum wave frequency of elastography has been limited to ~10 kHz due to the finite sensitivity…

Applied Physics · Physics 2022-11-22 Xu Feng , Guo-Yang Li , Seok-Hyun Yun

In the framework of algebraic inversion, Magnetic Resonance Elastography (MRE) repeatability, reproducibility and robustness were evaluated on extracted shear velocities (or elastic moduli). The same excitation system was implemented at two…

Lens tension is essential for accommodative vision but remains difficult to measure with precision. Here, we present an optical coherence elastography (OCE) technique that quantifies both tension and elastic modulus in the lens capsule and…

Applied Physics · Physics 2025-12-29 Xu Feng , Guo-yang Li , Yuxuan Jiang , Owen Shortt-Nguyen , Seok-Hyun Yun

Understanding corneal stiffness is valuable for improving refractive surgery, detecting corneal abnormalities, and assessing intraocular pressure. However, accurately measuring the elastic properties, particularly the tensile and shear…

Medical Physics · Physics 2023-08-11 Guo-Yang Li , Xu Feng , Seok-Hyun Yun

Displacement estimation in optical coherence tomography (OCT) imaging is relevant for several potential applications, e.g. for optical coherence elastography (OCE) for corneal biomechanical characterization. Larger displacements may be…

Image and Video Processing · Electrical Eng. & Systems 2021-03-22 Hossein Khodadadi , Orcun Goksel , Sabine Kling

Magnetic resonance elastography (MRE) and related elastography techniques are emerging as quantitative diagnostic tools for assessing tissue microstructure and pathology. To determine descriptive parameters of the tissues' properties, a…

Medical Physics · Physics 2026-03-17 Laura Ruhland , Jing Guo , Ingolf Sack , Kai Willner

Tissue viscoelasticity is becoming an increasingly useful biomarker beyond elasticity and can theoretically be estimated using shear wave elastography (SWE), by inverting the propagation and attenuation characteristics of shear waves.…

Biological Physics · Physics 2024-11-19 Shuvrodeb Adikary , Matthew W. Urban , Murthy N. Guddati

Objectives: Magnetic resonance elastography (MRE) is a noninvasive technique for assessing the viscoelastic properties of soft biological tissues in vivo, with potential relevance for pediatric tumor evaluation. This study aimed to evaluate…

Shear wave absolute vibro-elastography (S-WAVE) is an imaging technique that generates steady-state shear waves inside the tissue using multi-frequency excitation from an external vibration source. In this work, plane wave imaging is…

Image and Video Processing · Electrical Eng. & Systems 2023-07-27 Hoda S. Hashemi , Reza Zahiri Azar , Septimiu E. Salcudean , Robert N. Rohling

The mechanisms of flow in suspensions of soft particles above the glass-transition volume fraction and in the jammed state were probed using Orthogonal Superposition Rheometry (OSR). A small amplitude oscillatory shear flow is superimposed…

Soft Condensed Matter · Physics 2026-02-06 Panagiota Bogri , Gabriele Pagani , Jan Vermant , Joris Sprakel , George Petekidis
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