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Masked Diffusion Models (MDMs) have emerged as a powerful generative modeling technique. Despite their remarkable results, they typically suffer from slow inference with several steps. In this paper, we propose Di$\mathtt{[M]}$O, a novel…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Yuanzhi Zhu , Xi Wang , Stéphane Lathuilière , Vicky Kalogeiton

Three-dimensional molecular generators based on diffusion models can now reach near-crystallographic accuracy, yet they remain fragmented across tasks. SMILES-only inputs, two-stage pretrain-finetune pipelines, and one-task-one-model…

Biomolecules · Quantitative Biology 2025-07-11 Dong Xu , Zhangfan Yang , Sisi Yuan , Jenna Xinyi Yao , Jiangqiang Li , Junkai Ji

While diffusion models can learn complex distributions, sampling requires a computationally expensive iterative process. Existing distillation methods enable efficient sampling, but have notable limitations, such as performance degradation…

Machine Learning · Computer Science 2024-12-09 Sirui Xie , Zhisheng Xiao , Diederik P Kingma , Tingbo Hou , Ying Nian Wu , Kevin Patrick Murphy , Tim Salimans , Ben Poole , Ruiqi Gao

Diffusion models are increasingly used as powerful conditional generators, yet real deployments often involve multiple target distributions arising from different tasks, e.g., diverse prompt domains in text-to-image generation, or multiple…

Machine Learning · Computer Science 2026-05-26 Ziheng Cheng , Yixiao Huang , Hanlin Zhu , Haoran Geng , Somayeh Sojoudi , Jitendra Malik , Pieter Abbeel , Xin Guo

A molecule's geometry, also known as conformation, is one of a molecule's most important properties, determining the reactions it participates in, the bonds it forms, and the interactions it has with other molecules. Conventional…

Machine Learning · Computer Science 2020-01-01 Elman Mansimov , Omar Mahmood , Seokho Kang , Kyunghyun Cho

Diffusion models are promising for joint trajectory prediction and controllable generation in autonomous driving, but they face challenges of inefficient inference steps and high computational demands. To tackle these challenges, we…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Yixiao Wang , Chen Tang , Lingfeng Sun , Simone Rossi , Yichen Xie , Chensheng Peng , Thomas Hannagan , Stefano Sabatini , Nicola Poerio , Masayoshi Tomizuka , Wei Zhan

Learning to generate graphs is challenging as a graph is a set of pairwise connected, unordered nodes encoding complex combinatorial structures. Recently, several works have proposed graph generative models based on normalizing flows or…

Machine Learning · Computer Science 2023-06-21 Xiaohui Chen , Yukun Li , Aonan Zhang , Li-Ping Liu

Deep generative models have been praised for their ability to learn smooth latent representation of images, text, and audio, which can then be used to generate new, plausible data. However, current generative models are unable to work with…

Machine Learning · Computer Science 2019-09-09 Bidisha Samanta , Abir De , Gourhari Jana , Pratim Kumar Chattaraj , Niloy Ganguly , Manuel Gomez-Rodriguez

Diffusion models have significantly advanced the state of the art in image, audio, and video generation tasks. However, their applications in practical scenarios are hindered by slow inference speed. Drawing inspiration from the…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Chen Xu , Tianhui Song , Weixin Feng , Xubin Li , Tiezheng Ge , Bo Zheng , Limin Wang

In genome-scale constraint-based metabolic models, gene deletion strategies are essential for achieving growth-coupled production, where cell growth and target metabolite synthesis occur simultaneously. Despite the inherently networked…

Quantitative Methods · Quantitative Biology 2026-04-10 Ziwei Yang , Takeyuki Tamura

Diffusion distillation, exemplified by Distribution Matching Distillation (DMD), has shown great promise in few-step generation but often sacrifices quality for sampling speed. While integrating Reinforcement Learning (RL) into distillation…

Machine Learning · Computer Science 2026-04-22 Linwei Dong , Ruoyu Guo , Ge Bai , Zehuan Yuan , Yawei Luo , Changqing Zou

Large video diffusion and flow models have achieved remarkable success in high-quality video generation, but their use in real-time interactive applications remains limited due to their inefficient multi-step sampling process. In this work,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Weili Nie , Julius Berner , Nanye Ma , Chao Liu , Saining Xie , Arash Vahdat

Discrete diffusion models offer a promising alternative to autoregressive generation through parallel decoding, but they suffer from a sampling wall: once categorical sampling occurs, rich distributional information collapses into one-hot…

Machine Learning · Computer Science 2026-05-14 Mingyu Jo , Jaesik Yoon , Justin Deschenaux , Caglar Gulcehre , Sungjin Ahn

In the realm of generative models for graphs, extensive research has been conducted. However, most existing methods struggle with large graphs due to the complexity of representing the entire joint distribution across all node pairs and…

Social and Information Networks · Computer Science 2024-05-15 Andreas Bergmeister , Karolis Martinkus , Nathanaël Perraudin , Roger Wattenhofer

We introduce Efficient Motion Diffusion Model (EMDM) for fast and high-quality human motion generation. Current state-of-the-art generative diffusion models have produced impressive results but struggle to achieve fast generation without…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Wenyang Zhou , Zhiyang Dou , Zeyu Cao , Zhouyingcheng Liao , Jingbo Wang , Wenjia Wang , Yuan Liu , Taku Komura , Wenping Wang , Lingjie Liu

Energy-based models for discrete domains, such as graphs, explicitly capture relative likelihoods, naturally enabling composable probabilistic inference tasks like conditional generation or enforcing constraints at test-time. However,…

In this paper, we address the problem of generative dataset distillation that utilizes generative models to synthesize images. The generator may produce any number of images under a preserved evaluation time. In this work, we leverage the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Junqiao Fan , Yunjiao Zhou , Min Chang Jordan Ren , Jianfei Yang

In the digital age, advanced image editing tools pose a serious threat to the integrity of visual content, making image forgery detection and localization a key research focus. Most existing Image Manipulation Localization (IML) methods…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Yachun Mi , Xingyang He , Shixin Sun , Yu Li , Yanting Li , Zhixuan Li , Jian Jin , Chen Hui , Shaohui Liu

Finding frequently occurring subgraph patterns or network motifs in neural architectures is crucial for optimizing efficiency, accelerating design, and uncovering structural insights. However, as the subgraph size increases,…

Machine Learning · Computer Science 2026-02-04 Yikang Yang , Zhengxin Yang , Minghao Luo , Luzhou Peng , Hongxiao Li , Wanling Gao , Lei Wang , Jianfeng Zhan

We consider feature representation learning problem of molecular graphs. Graph Neural Networks have been widely used in feature representation learning of molecular graphs. However, most existing methods deal with molecular graphs…

Machine Learning · Computer Science 2022-06-08 Zhaoning Yu , Hongyang Gao