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With the development of next generation sequencing technology, researchers have now been able to study the microbiome composition using direct sequencing, whose output are bacterial taxa counts for each microbiome sample. One goal of…

Applications · Statistics 2013-05-24 Jun Chen , Hongzhe Li

Microorganisms play a critical role in host health. The advancement of high-throughput sequencing technology provides opportunities for a deeper understanding of microbial interactions. However, due to the limitations of 16S ribosomal RNA…

Methodology · Statistics 2021-05-12 Hee Cheol Chung , Irina Gaynanova , Yang Ni

Surveys of microbial biodiversity such as the Earth Microbiome Project (EMP) and the Human Microbiome Project (HMP) have revealed robust ecological patterns across different environments. A major goal in ecology is to leverage these…

Populations and Evolution · Quantitative Biology 2020-03-05 Robert Marsland , Wenping Cui , Pankaj Mehta

The human-associated microbiome is closely tied to human health and is of substantial clinical interest. Metagenomics-based tools are emerging for clinical diagnostics, tracking the spread of diseases, and surveillance of potential…

High-throughput techniques are leading to an explosive growth in the size of biological databases and creating the opportunity to revolutionize our understanding of life and disease. Interpretation of these data remains, however, a major…

Molecular Networks · Quantitative Biology 2009-11-11 Roger Guimera , Luis A. Nunes Amaral

The explosion in known microbial diversity in the last two decades has made it abundantly clear that microbes in the environment do not exist in isolation; they are members of communities. Accordingly, omics approaches such as metagenomics…

Quantitative Methods · Quantitative Biology 2024-07-15 James C. Kosmopoulos , Karthik Anantharaman

The gut microbiota has emerged as a fundamental regulator of sleep physiology, influencing neural, endocrine, and immune pathways through the gut-microbiota-brain axis (GMBA). This bidirectional communication system modulates…

Neurons and Cognition · Quantitative Biology 2025-12-11 Enso Onill Torres Alegre

Objective: As metabolic cost is a primary factor influencing humans' gait, we want to deepen our understanding of metabolic energy expenditure models. Therefore, this paper identifies the parameters and input variables, such as muscle or…

Machine Learning · Computer Science 2023-11-08 Markus Gambietz , Marlies Nitschke , Jörg Miehling , Anne Koelewijn

One of the fundamental problems in biology concerns the method by which a cluster of organisms can regulate the proportion of individuals that perform various roles or modes as if each individual knows a whole situation without a leader. A…

Adaptation and Self-Organizing Systems · Physics 2015-12-21 Mayuko Iwamoto , Daishin Ueyama

Microbiome studies increasingly indicate that disease-associated shifts cannot be understood from compositional changes alone. The functional architecture of microbial communities encoded in patterns of association among microbial gene…

Other Quantitative Biology · Quantitative Biology 2026-04-28 Marianna Milano , Pietro Hiram Guzzi

Microbial communities play important roles in the function and maintenance of various biosystems, ranging from human body to the environment. Current methods for analysis of microbial communities are typically based on taxonomic…

Genomics · Quantitative Biology 2015-12-02 Ehsaneddin Asgari , Kiavash Garakani , Mohammad R. K Mofrad

Bacteria are highly adaptive microorganisms that thrive in a wide range of growth conditions via changes in cell morphologies and macromolecular composition. How bacterial morphologies are regulated in diverse environmental conditions is a…

Cell Behavior · Quantitative Biology 2021-10-26 Diana Serbanescu , Nikola Ojkic , Shiladitya Banerjee

The interactions among the constituent members of a microbial community play a major role in determining the overall behavior of the community and the abundance levels of its members. These interactions can be modeled using a network whose…

Artificial Intelligence · Computer Science 2020-10-20 Sahar Tavakoli

We introduce various models for cellulose bio-degradation by micro-organisms. Those models rely on complex chemical mechanisms, involve the structure of the cellulose chains and are allowed to depend on the phenotypical traits of the…

Dynamical Systems · Mathematics 2020-11-09 Pierre-Emmanuel Jabin , Alexey Miroshnikov , Robin Young

Equilibrium aspects of molecular recognition of rigid biomolecules are investigated using coarse-grained lattice models. The analysis is carried out in two stages. First an ensemble of probe molecules is designed with respect to the target…

Biological Physics · Physics 2009-11-13 Hans Behringer , Andreas Degenhard , Friederike Schmid

We present a mathematical model based on a system of partial differential equations (PDEs) with cross-diffusion and reaction terms to describe ecological interactions between multiple bacterial species and substrates within microaggregates,…

Populations and Evolution · Quantitative Biology 2025-12-16 Viktoria Freingruber , Rebeca Gonzalez-Cabaleiro , Havva Yoldaş

A fundamental goal of microbial ecology is to understand what determines the diversity, stability, and structure of microbial ecosystems. The microbial context poses special conceptual challenges because of the strong mutual influences…

Biological Physics · Physics 2019-03-06 Robert Marsland , Wenping Cui , Joshua Goldford , Alvaro Sanchez , Kirill Korolev , Pankaj Mehta

This review focuses on microbiomes associated with residues within the context of other microbial habitats in cereal-producing agroecosystems such as phyllosphere or rhizosphere. We connect residue microbiome with the survival of…

Populations and Evolution · Quantitative Biology 2019-08-14 Lydie Kerdraon , Valérie Laval , Frédéric Suffert

Associative learning is one of the key mechanisms displayed by living organisms in order to adapt to their changing environments. It was early recognized to be a general trait of complex multicellular organisms but also found in "simpler"…

Cell Behavior · Quantitative Biology 2017-01-24 Javier Macia , Blai Vidiella , Ricard Sole

Assessing the synergistic high-order behaviors (HOBs) that emerge from underlying structural mechanisms is crucial to characterize complex systems. This work leverages the combined use of predictability and information measures to detect…

Quantitative Methods · Quantitative Biology 2025-12-16 Chiara Barà , Yuri Antonacci , Laura Sparacino , Helder Pinto , Michal Javorka , Sebastiano Stramaglia , Luca Faes