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In this work, we explore the Transcriptomics Atlas pipeline adapted for cost-efficient and high-throughput computing in the cloud. We propose a scalable, cloud-native architecture designed for running a resource-intensive aligner -- STAR --…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-06-17 Piotr Kica , Sabina Lichołai , Michał Orzechowski , Maciej Malawski

We propose a scalable, cloud-native architecture designed for Transcriptomics Atlas Pipeline, using a resource-intensive STAR aligner and processing tens or hundreds of terabytes of RNA-seq data. We implement the pipeline using AWS cloud…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-09-11 Piotr Kica , Sabina Lichołai , Michał Orzechowski , Maciej Malawski

Cloud computing offers on-demand, scalable computing and storage, and has become an essential resource for the analyses of big biomedical data. The usual approach to cloud computing requires users to reserve and provision virtual servers.…

Quantitative Methods · Quantitative Biology 2018-08-01 Dimitar Kumanov , Ling-Hong Hung , Wes Lloyd , Ka Yee Yeung

Serverless platforms have attracted attention due to their promise of elasticity, low cost, and fast deployment. Instead of using a fixed virtual machine (VM) infrastructure, which can incur considerable costs to operate and run, serverless…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-02-15 Michael Wawrzoniak , Ingo Müller , Rodrigo Bruno , Ana Klimovic , Gustavo Alonso

Data processing systems are increasingly deployed in the cloud. While monolithic systems run fully on virtual servers, recent systems embrace cloud infrastructure and utilize the disaggregation of compute and storage to scale them…

Databases · Computer Science 2025-01-15 Thomas Bodner , Theo Radig , David Justen , Daniel Ritter , Tilmann Rabl

The event-driven and elastic nature of serverless runtimes makes them a very efficient and cost-effective alternative for scaling up computations. So far, they have mostly been used for stateless, data parallel and ephemeral computations.…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-01-11 Arda Aytekin , Mikael Johansson

Serverless computing offers the potential to program the cloud in an autoscaling, pay-as-you go manner. In this paper we address critical gaps in first-generation serverless computing, which place its autoscaling potential at odds with…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-12-11 Joseph M. Hellerstein , Jose Faleiro , Joseph E. Gonzalez , Johann Schleier-Smith , Vikram Sreekanti , Alexey Tumanov , Chenggang Wu

Much like on-premises systems, the natural choice for running database analytics workloads in the cloud is to provision a cluster of nodes to run a database instance. However, analytics workloads are often bursty or low volume, leaving…

Databases · Computer Science 2019-11-27 Matthew Perron , Raul Castro Fernandez , David DeWitt , Samuel Madden

Serverless computing has become an important model in cloud computing and influenced the design of many applications. Here, we provide our perspective on how the recent landscape of serverless computing for scientific applications looks…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-09-06 Maciej Malawski , Bartosz Balis

Making serverless computing widely applicable requires detailed performance understanding. Although contemporary benchmarking approaches exist, they report only coarse results, do not apply distributed tracing, do not consider asynchronous…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-05-17 Joel Scheuner , Simon Eismann , Sacheendra Talluri , Erwin van Eyk , Cristina Abad , Philipp Leitner , Alexandru Iosup

Serverless computing has gained a significant traction in recent times because of its simplicity of development, deployment and fine-grained billing. However, while implementing complex services comprising databases, file stores, or more…

Networking and Internet Architecture · Computer Science 2019-11-19 Bishakh Chandra Ghosh , Sourav Kanti Addya , Nishant Baranwal Somy , Shubha Brata Nath , Sandip Chakraborty , Soumya K Ghosh

In this paper, we present STAR, a new distributed in-memory database with asymmetric replication. By employing a single-node non-partitioned architecture for some replicas and a partitioned architecture for other replicas, STAR is able to…

Databases · Computer Science 2019-07-23 Yi Lu , Xiangyao Yu , Samuel Madden

This paper explores resource allocation in serverless cloud computing platforms and proposes an optimization approach for autoscaling systems. Serverless computing relieves users from resource management tasks, enabling focus on application…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-10-31 Harold Ship , Evgeny Shindin , Chen Wang , Diana Arroyo , Asser Tantawi

Serverless computing is an approach to cloud computing that allows programmers to run serverless functions in response to external events. Serverless functions are priced at sub-second granularity, support transparent elasticity, and…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-08-05 Emily Herbert , Arjun Guha

Serverless computing, commonly offered as Function-as-a-Service, was initially designed for small, lean applications. However, there has been an increasing desire to run larger, more complex applications (what we call bulky applications) in…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-05-14 Zhiyuan Guo , Zachary Blanco , Junda Chen , Jinmou Li , Zerui Wei , Bili Dong , Ishaan Pota , Mohammad Shahrad , Harry Xu , Yiying Zhang

As data-intensive applications grow, batch processing in limited-resource environments faces scalability and resource management challenges. Serverless computing offers a flexible alternative, enabling dynamic resource allocation and…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-02-18 Amine Barrak , Emna Ksontini

Serverless computing provides just-in-time infrastructure provisioning with rapid elasticity and a finely-grained pricing model. As full control of resource allocation is in the hands of the cloud provider and applications only consume…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-10 Natalie Carl , Tobias Pfandzelter , David Bermbach

Serverless computing has attracted a broad range of applications due to its ease of use and resource elasticity. However, developing serverless applications often poses a dilemma -- relying on general-purpose serverless platforms can fall…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-17 Minchen Yu , Yinghao Ren , Jiamu Zhao , Jiaqi Li

Serverless computing is increasingly popular because of the promise of lower cost and the convenience it provides to users who do not need to focus on server management. This has resulted in the availability of a number of proprietary and…

Performance · Computer Science 2019-12-16 Junfeng Li , Sameer G. Kulkarni , K. K. Ramakrishnan , Dan Li

Serverless computing -- an emerging cloud-native paradigm for the deployment of applications and services -- represents an evolution in cloud application development, programming models, abstractions, and platforms. It promises a real…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-06-10 Paul Castro , Vatche Ishakian , Vinod Muthusamy , Aleksander Slominski
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