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With the advent of Large Language Models (LLMs), medical artificial intelligence (AI) has experienced substantial technological progress and paradigm shifts, highlighting the potential of LLMs to streamline healthcare delivery and improve…
Large language models (LLMs) achieve strong average performance yet remain unreliable at the instance level, with frequent hallucinations, brittle failures, and poorly calibrated confidence. We study reliability through the lens of…
Building trustworthy clinical AI systems requires not only accurate predictions but also transparent, biologically grounded explanations. We present \texttt{DiagnoLLM}, a hybrid framework that integrates Bayesian deconvolution, eQTL-guided…
Large Language Models (LLMs) are being adopted at an unprecedented rate, yet still face challenges in knowledge-intensive domains like biomedicine. Solutions such as pre-training and domain-specific fine-tuning add substantial computational…
The rapid adoption of large language models (LLMs) in customer service introduces new risks, as malicious actors can exploit them to conduct large-scale user impersonation through machine-generated text (MGT). Current MGT detection methods…
Metadata play a crucial role in ensuring the findability, accessibility, interoperability, and reusability of datasets. This paper investigates the potential of large language models (LLMs), specifically GPT-4, to improve adherence to…
Information overload is a major obstacle to scientific progress. The explosive growth in scientific literature and data has made it ever harder to discover useful insights in a large mass of information. Today scientific knowledge is…
Medical large language models (LLMs), including custom medical GPTs (MedGPTs) and open-source models, are increasingly deployed on web platforms to provide clinical guidance. However, they pose risks of hallucination, policy noncompliance,…
Large Language Models (LLMs) have recently demonstrated remarkable performance in general tasks across various fields. However, their effectiveness within specific domains such as drug development remains challenges. To solve these…
Effective pre-training of large language models (LLMs) has been challenging due to the immense resource demands and the complexity of the technical processes involved. This paper presents a detailed technical report on YuLan-Mini, a highly…
Large Language Models (LLMs) like LLaMA, Mistral, and Gemma are increasingly used in decision-critical domains such as healthcare, law, and finance, yet their reliability remains uncertain. They often make overconfident errors, degrade…
Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses…
Since the release of ChatGPT and GPT-4, large language models (LLMs) and multimodal large language models (MLLMs) have attracted widespread attention for their exceptional capabilities in understanding, reasoning, and generation,…
We propose PPLqa, an easy to compute, language independent, information-theoretic metric to measure the quality of responses of generative Large Language Models (LLMs) in an unsupervised way, without requiring ground truth annotations or…
Recently, Large Language Models (LLMs) have gained significant traction in medical domain, especially in developing a QA systems to Medical QA systems for enhancing access to healthcare in low-resourced settings. This paper compares five…
Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve…
In this paper, we champion the use of structured and semantic content representation of discourse-based scholarly communication, inspired by tools like Wikipedia infoboxes or structured Amazon product descriptions. These representations…
Large Language Models (LLMs) achieve gold-medal performance across many benchmarks, yet it remains unclear whether such success reflects genuine reasoning or pattern matching. From a cognitive science perspective, an informative test is…
Vision-language models (VLMs) are increasingly adapted through domain-specific fine-tuning, yet it remains unclear whether this improves reasoning beyond superficial visual cues, particularly in high-stakes domains like medicine. We…
This paper examines the reasoning capabilities of Large Language Models (LLMs) from a novel perspective, focusing on their ability to operate within formally specified, rule-governed environments. We evaluate four LLMs (Gemini 2.5 Pro and…