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In today's world of big data, computational analysis has become a key driver of biomedical research. Recent exponential growth in the volume of available omics data has reshaped the landscape of contemporary biology, creating demand for a…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-12-09 Jaqueline J. Brito , Thiago Mosqueiro , Jeremy Rotman , Victor Xue , Douglas J. Chapski , Juan De la Hoz , Paulo Matias , Lana Martin , Alex Zelikovsky , Matteo Pellegrinni , Serghei Mangul

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling,…

Computation and Language · Computer Science 2026-03-03 Zhenyu Wang , Zikang Wang , Jiyue Jiang , Pengan Chen , Xiangyu Shi , Yu Li

The drug development process necessitates that pharmacologists undertake various tasks, such as reviewing literature, formulating hypotheses, designing experiments, and interpreting results. Each stage requires accessing and querying vast…

Computation and Language · Computer Science 2023-08-01 Hong Lu , Chuan Li , Yinheng Li , Jie Zhao

The paper tackles the issue of mapping logic axioms formalised in the Ontology Web Language (OWL) within the Object-Oriented Programming (OOP) paradigm. The issues of mapping OWL axioms hierarchies and OOP objects hierarchies are due to…

Artificial Intelligence · Computer Science 2024-04-22 Luca Buoncompagni , Fulvio Mastrogiovanni

Large language models (LLMs) show promise for aiding graduate level education, but are limited by their training data and potential confabulations. We developed ChemTAsk, an open-source pipeline that combines LLMs with retrieval-augmented…

Autonomous science agents built on large language models (LLMs) are increasingly used to generate hypotheses, design experiments, and produce reports. However, prior work mainly targets open-ended scientific problems with subjective outputs…

Computation and Language · Computer Science 2026-03-24 Tianshu Zhang , Huan Sun

This research was focused on the efficient collection of experimental Metal-Organic Framework (MOF) data from scientific literature to address the challenges of accessing hard-to-find data and improving the quality of information available…

Materials Science · Physics 2024-04-23 Wonseok Lee , Yeonghun Kang , Taeun Bae , Jihan Kim

This paper presents the Never Ending Open Learning Adaptive Framework (NEOLAF), an integrated neural-symbolic cognitive architecture that models and constructs intelligent agents. The NEOLAF framework is a superior approach to constructing…

Active learning (AL) accelerates scientific discovery by prioritizing the most informative experiments, but traditional machine learning (ML) models used in AL suffer from cold-start limitations and domain-specific feature engineering,…

Machine Learning · Computer Science 2025-12-05 Hongchen Wang , Rafael Espinosa Castañeda , Jay R. Werber , Yao Fehlis , Edward Kim , Jason Hattrick-Simpers

BEFANA is a free and open-source software tool for ecological network analysis and visualisation. It is adapted to ecologists' needs and allows them to study the topology and dynamics of ecological networks as well as apply selected machine…

Quantitative Methods · Quantitative Biology 2026-03-12 Martin Marzidovšek , Vid Podpečan , Erminia Conti , Marko Debeljak , Christian Mulder

Branch is a web application that provides users with no programming with the ability to interact directly with large biomedical datasets. The interaction is mediated through a collaborative graphical user interface for building and…

Applications · Statistics 2016-05-04 Karthik Gangavarapu , Vyshakh Babji , Tobias Meißner , Andrew I. Su , Benjamin M. Good

We find ourselves in the midst of an explosion in artificial intelligence research, particularly with large language models (LLMs). These models have diverse applications spanning finance, commonsense knowledge graphs, medicine, and visual…

Software Engineering · Computer Science 2025-08-08 Gang Xu , Airong Wang , Yushan Pan

To exploit the Web Ontology Language OWL as an answer set programming (ASP) language, we introduce the notion of bounded model semantics, as an intuitive and computationally advantageous alternative to its classical semantics. We show that…

Programming Languages · Computer Science 2015-11-04 Sarah Alice Gaggl , Sebastian Rudolph , Lukas Schweizer

Gene Ontology (GO) is the most important resource for gene function annotation. It provides a way to unify biological knowledge across different species via a dynamic and controlled vocabulary. GO is now widely represented in the Semantic…

Genomics · Quantitative Biology 2019-09-26 Yanying Wu

Large Language Models (LLMs) excel at general code generation, yet translating natural-language trading intents into correct option strategies remains challenging. Real-world option design requires reasoning over massive, multi-dimensional…

Artificial Intelligence · Computer Science 2026-03-18 Haochen Luo , Zhengzhao Lai , Junjie Xu , Yifan Li , Tang Pok Hin , Yuan Zhang , Chen Liu

Large Language Models (LLMs) possess substantial reasoning capabilities and are increasingly applied to optimization tasks, particularly in synergy with evolutionary computation. However, while recent surveys have explored specific aspects…

Neural and Evolutionary Computing · Computer Science 2026-01-08 Yisong Zhang , Ran Cheng , Guoxing Yi , Kay Chen Tan

Large Language Models (LLMs) are increasingly deployed in high-stakes contexts where their outputs influence real-world decisions. However, evaluating bias in LLM outputs remains methodologically challenging due to sensitivity to prompt…

Computation and Language · Computer Science 2026-01-13 William Guey , Wei Zhang , Pei-Luen Patrick Rau , Pierrick Bougault , Vitor D. de Moura , Bertan Ucar , Jose O. Gomes

Merging natural language interfaces with computational fluid dynamics (CFD) workflows presents transformative opportunities for both industry and research. In this study, we introduce OptMetaOpenFOAM - a novel framework that bridges…

Artificial Intelligence · Computer Science 2025-03-04 Yuxuan Chen , Long Zhang , Xu Zhu , Hua Zhou , Zhuyin Ren

Large Language Models (LLMs) have emerged as transformative tools for natural language understanding and user intent resolution, enabling tasks such as translation, summarization, and, increasingly, the orchestration of complex workflows.…

Software Engineering · Computer Science 2025-11-12 Justus Flerlage , Alexander Acker , Odej Kao
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