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Although large pre-trained models of code have delivered significant advancements in various code processing tasks, there is an impediment to the wide and fluent adoption of these powerful models in software developers' daily workflow:…

Software Engineering · Computer Science 2022-09-07 Jieke Shi , Zhou Yang , Bowen Xu , Hong Jin Kang , David Lo

Recent advancements in discrete image generation showed that scaling the VQ codebook size significantly improves reconstruction fidelity. However, training generative models with a large VQ codebook remains challenging, typically requiring…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Shufan Li , Jiuxiang Gu , Kangning Liu , Zhe Lin , Aditya Grover , Jason Kuen

Despite rapid advancements, machine learning, particularly deep learning, is hindered by the need for large amounts of labeled data to learn meaningful patterns without overfitting and immense demands for computation and storage, which…

Machine Learning · Computer Science 2025-06-30 Xiaobo Zhao , Aaron Hurst , Panagiotis Karras , Daniel E. Lucani

Data compression and decompression have become vital components of big-data applications to manage the exponential growth in the amount of data collected and stored. Furthermore, big-data applications have increasingly adopted GPUs due to…

Predicting protein function from amino acid sequence remains a central challenge in data-scarce (low-$N$) regimes, limiting machine learning-guided protein design when only small amounts of assay-labeled sequence-function data are…

Machine Learning · Computer Science 2025-08-27 Darin Tsui , Kunal Talreja , Amirali Aghazadeh

Today's computing systems require moving data back-and-forth between computing resources (e.g., CPUs, GPUs, accelerators) and off-chip main memory so that computation can take place on the data. Unfortunately, this data movement is a major…

Hardware Architecture · Computer Science 2022-05-31 Geraldo F. Oliveira , Amirali Boroumand , Saugata Ghose , Juan Gómez-Luna , Onur Mutlu

Decentralized training enables learning with distributed datasets generated at different locations without relying on a central server. In realistic scenarios, the data distribution across these sparsely connected learning agents can be…

Machine Learning · Computer Science 2025-02-27 Sakshi Choudhary , Sai Aparna Aketi , Kaushik Roy

Suffix Array (SA) is a cardinal data structure in many pattern matching applications, including data compression, plagiarism detection and sequence alignment. However, as the volumes of data increase abruptly, the construction of SA is not…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-05-16 Hsiang-Huang Wu , Chien-Min Wang , Hsuan-Chi Kuo , Wei-Chun Chung , Jan-Ming Ho

Stacked Auto-Encoder (SAE) is a kind of deep learning algorithm for unsupervised learning. Which has multi layers that project the vector representation of input data into a lower vector space. These projection vectors are dense…

Computer Vision and Pattern Recognition · Computer Science 2016-10-11 Fei Hu , Changjiu Pu , Haowei Gao , Mengzi Tang , Li Li

Composite DNA is a recent novel method to increase the information capacity of DNA-based data storage above the theoretical limit of 2 bits/symbol. In this method, every composite symbol does not store a single DNA nucleotide but a mixture…

Information Theory · Computer Science 2025-01-22 Tuan Thanh Nguyen , Chen Wang , Kui Cai , Yiwei Zhang , Zohar Yakhini

This paper demonstrates the utility of organized numerical representations of genes in research involving flat string gene formats (i.e., FASTA/FASTQ5). FASTA/FASTQ files have several current limitations, such as their large file sizes,…

Genomics · Quantitative Biology 2023-08-11 Daniel H. Um , David A. Knowles , Gail E. Kaiser

Masked graph autoencoder (MGAE) has emerged as a promising self-supervised graph pre-training (SGP) paradigm due to its simplicity and effectiveness. However, existing efforts perform the mask-then-reconstruct operation in the raw data…

Machine Learning · Computer Science 2023-04-07 Wenxuan Tu , Qing Liao , Sihang Zhou , Xin Peng , Chuan Ma , Zhe Liu , Xinwang Liu , Zhiping Cai

Genome sequencing is essential to decode genetic information, identify organisms, understand diseases and advance personalized medicine. A critical step in any genome sequencing technique is genome assembly. However, de novo genome…

Sequence alignment is a fundamental process in computational biology which identifies regions of similarity in biological sequences. With the exponential growth in the volume of data in bioinformatics databases, the time, processing power,…

Hardware Architecture · Computer Science 2025-07-31 Nasrin Akbari , Mehdi Modarressi , Alireza Khadem

Microbiome functions are encoded within the genes of the community-wide metagenome. A natural question is whether properties of a microbial community can be predicted just from knowing the raw DNA sequences of its members. In this work, we…

Genomics · Quantitative Biology 2026-05-13 Younhun Kim , Georg K. Gerber , Travis E. Gibson

DNA sequencing, especially of microbial genomes and metagenomes, has been at the core of recent research advances in large-scale comparative genomics. The data deluge has resulted in exponential growth in genomic datasets over the past…

Semantic communication has emerged as new paradigm shifts in 6G from the conventional syntax-oriented communications. Recently, the wireless broadcast technology has been introduced to support semantic communication system toward higher…

Signal Processing · Electrical Eng. & Systems 2024-02-01 Mingze Gong , Shuoyao Wang , Fangwei Ye , Suzhi Bi

In the recent years, heterogeneous machine learning accelerators have become of significant interest in science, engineering and industry. The major processing speed bottlenecks in these platforms come from (a) an electronic data…

Optics · Physics 2022-08-25 Maria Solyanik-Gorgone , Behrouz Movahhed , Volker J Sorger

Large language models (LLMs) can generate syntactically valid optimization programs, yet often struggle to reliably choose an effective modeling strategy, leading to incorrect formulations and inefficient solver behavior. We propose SAGE, a…

Artificial Intelligence · Computer Science 2026-05-05 Ruiqing Zhao , Fengzhi Li , Yuan Zuo , Rui Liu , Yansong Liu , Yunfei Ma , Fanyu Meng , Junlan Feng

The electrocardiogram (ECG) is an inexpensive and widely available tool for cardiovascular assessment. Despite its standardized format and small file size, the high complexity and inter-individual variability of ECG signals (typically a…

Machine Learning · Computer Science 2024-10-31 Christopher J. Harvey , Sumaiya Shomaji , Zijun Yao , Amit Noheria