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Predicting the binding affinity between small molecules and target macromolecules while combining both speed and accuracy, is a cornerstone of modern computational drug discovery which is critical for accelerating therapeutic development.…

Nuclear many-body calculations are computationally demanding. An estimate of their accuracy is often hampered by the limited amount of computational resources even on present-day supercomputers. We provide an extrapolation method based on…

Nuclear Theory · Physics 2009-11-10 H. Zhan , A. Nogga , B. R. Barrett , J. P. Vary , P. Navratil

The calculation of the MP2 correlation energy for extended systems can be viewed as a multi-dimensional integral in the thermodynamic limit, and the standard method for evaluating the MP2 energy can be viewed as a trapezoidal quadrature…

Computational Physics · Physics 2023-04-10 Xin Xing , Xiaoxu Li , Lin Lin

We have developed a new basis set family, denoted aug-cc-pVnZ-F12 (or aVnZ-F12 for short), for explicitly correlated calculations. The sets included in this family were constructed by supplementing the corresponding cc-pVnZ-F12 sets with…

Chemical Physics · Physics 2017-12-27 Nitai Sylvetsky , Manoj Kumar Kesharwani , Jan M. L. Martin

The atomic cluster expansion (ACE) was proposed recently as a new class of data-driven interatomic potentials with a formally complete basis set. Since the development of any interatomic potential requires a careful selection of training…

Materials Science · Physics 2022-12-20 Yury Lysogorskiy , Anton Bochkarev , Matous Mrovec , Ralf Drautz

The computational acceleration of orbital-invariant local correlation methods on graphics processing units (GPUs) has remained largely unexplored due to substantial algorithmic complexities. The runtime efficiency of GPU-implemented local…

Chemical Physics · Physics 2026-03-18 Qiujiang Liang , Jun Yang

Atomic cluster expansion (ACE) methods provide a systematic way to describe particle local environments of arbitrary body order. For practical applications it is often required that the basis of cluster functions be symmetrized with respect…

Materials Science · Physics 2024-02-27 James M. Goff , Charles Sievers , Mitchell A. Wood , Aidan P. Thompson

We incorporate explicit, non-perturbative treatment of spin-orbit coupling into ab initio auxiliary-field quantum Monte Carlo (AFQMC) calculations. The approach allows a general computational framework for molecular and bulk systems in…

Strongly Correlated Electrons · Physics 2023-02-16 Brandon Eskridge , Henry Krakauer , Hao Shi , Shiwei Zhang

This paper introduces a simple variant of the power method. It is shown analytically and numerically to accelerate convergence to the dominant eigenvalue/eigenvector pair; and, it is particularly effective for problems featuring a small…

Numerical Analysis · Mathematics 2020-09-01 Nilima Nigam , Sara Pollock

Current noisy intermediate-scale quantum (NISQ) trapped-ion devices are subject to errors which can significantly impact the accuracy of calculations if left unchecked. A form of error mitigation called zero noise extrapolation (ZNE) can…

We present a many-body expansion (MBE) formulation and implementation for efficient computation of analytical energy gradients from OSV-MP2 theory based on our earlier work (Zhou et al. J. Chem. Theory Comput. 2020, 16, 196-210). The…

Chemical Physics · Physics 2021-11-15 Qiujiang Liang , Jun Yang

In this work we propose a novel composite method for accurate calculation of the energies of many-electron atoms. The dominant contribution to the energy (pair energies) are calculated by using explicitly correlated factorisable coupled…

Atomic Physics · Physics 2018-12-12 Michal Przybytek , Michal Lesiuk

Earlier papers introduced a method of accurately estimating the angular cosmic microwave background (CMB) temperature power spectrum based on Gibbs sampling. Here we extend this framework to polarized data. All advantages of the Gibbs…

Accurate absolute binding free energy (ABFE) calculations can reduce the time and cost of identifying drug candidates from a diverse pool of molecules that may have been overlooked experimentally. These calculations typically employ…

Chemical Physics · Physics 2025-09-29 Steven Ayoub , Michael Barton , David A. Case , Tyler Luchko

Atomic basis sets are widely employed within quantum mechanics based simulations of matter. We introduce a machine learning model that adapts the basis set to the local chemical environment of each atom, prior to the start of self…

Chemical Physics · Physics 2024-04-29 Danish Khan , Maximilian L. Ach , O. Anatole von Lilienfeld

Quantum optimization algorithms offer a promising route to finding the ground states of target Hamiltonians on near-term quantum devices. None the less, it remains necessary to limit the evolution time and circuit depth as much as possible,…

Quantum Physics · Physics 2022-11-01 Chenfeng Cao , Yunlong Yu , Zipeng Wu , Nic Shannon , Bei Zeng , Robert Joynt

We propose a new variational Monte Carlo (VMC) method with an energy variance extrapolation for large-scale shell-model calculations. This variational Monte Carlo is a stochastic optimization method with a projected correlated condensed…

Nuclear Theory · Physics 2012-02-14 Takahiro Mizusaki , Noritaka Shimizu

When the number of strongly correlated electrons becomes larger, the single-reference coupled-cluster (CC) CCSD, CCSDT, etc. hierarchy displays an erratic behavior, while traditional multi-reference approaches may no longer be applicable…

Chemical Physics · Physics 2025-12-12 Ilias Magoulas , Jun Shen , Piotr Piecuch

Highly accurate methods such as coupled cluster (CC) techniques can be used for periodic systems within the framework of the method of increments. Its extension to low-dimensional conducting system is considered. To demonstrate the…

Materials Science · Physics 2012-01-31 Elena Voloshina

Twelve physics-informed machine learning models have been trained to model binding energy residuals. Our approach begins with determining the difference between measured experimental binding energies and three different mass models. Then…

Nuclear Theory · Physics 2025-03-12 Ian Bentley , James Tedder , Marwan Gebran , Ayan Paul