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Although traditional statistical techniques and machine learning methods have contributed significantly to genetics and, in particular, inherited disease diagnosis, they often struggle with complex, high-dimensional data, a challenge now…

Machine Learning · Computer Science 2025-08-29 Anton Changalidis , Yury Barbitoff , Yulia Nasykhova , Andrey Glotov

Dementia is a growing problem as our society ages, and detection methods are often invasive and expensive. Recent deep-learning techniques can offer a faster diagnosis and have shown promising results. However, they require large amounts of…

Computation and Language · Computer Science 2022-07-19 Anna Hlédiková , Dominika Woszczyk , Alican Akman , Soteris Demetriou , Björn Schuller

Alzheimer's disease (AD) is the fifth-leading cause of death among Americans aged 65 and older. Screening and early detection of AD and related dementias (ADRD) are critical for timely intervention and for identifying clinical trial…

Artificial Intelligence · Computer Science 2024-05-29 Jiankun Wang , Sumyeong Ahn , Taykhoom Dalal , Xiaodan Zhang , Weishen Pan , Qiannan Zhang , Bin Chen , Hiroko H. Dodge , Fei Wang , Jiayu Zhou

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care and to delay further progression. Speech based automatic AD screening systems provide a non-intrusive and more scalable alternative to other clinical…

Computation and Language · Computer Science 2023-04-03 Yi Wang , Jiajun Deng , Tianzi Wang , Bo Zheng , Shoukang Hu , Xunying Liu , Helen Meng

The intricate relationship between genetic variation and human diseases has been a focal point of medical research, evidenced by the identification of risk genes regarding specific diseases. The advent of advanced genome sequencing…

Quantitative Methods · Quantitative Biology 2024-01-19 Jiayu Chang , Shiyu Wang , Chen Ling , Zhaohui Qin , Liang Zhao

Alzheimer's disease (AD) is a common form of dementia that severely impacts patient health. As AD impairs the patient's language understanding and expression ability, the speech of AD patients can serve as an indicator of this disease. This…

Audio and Speech Processing · Electrical Eng. & Systems 2023-07-07 Hongmin Cai , Xiaoke Huang , Zhengliang Liu , Wenxiong Liao , Haixing Dai , Zihao Wu , Dajiang Zhu , Hui Ren , Quanzheng Li , Tianming Liu , Xiang Li

United States healthcare systems are struggling to meet the growing demand for neurological care, particularly in Alzheimer's disease and related dementias (ADRD). Generative AI built on language models (LLMs) now enables agentic AI systems…

Large language models (LLMs) can generate natural language texts for various domains and tasks, but their potential for clinical text mining, a domain with scarce, sensitive, and imbalanced medical data, is underexplored. We investigate…

Computation and Language · Computer Science 2024-02-23 Rumeng Li , Xun Wang , Hong Yu

Early diagnosis of Alzheimer's Disease (AD) faces multiple data-related challenges, including high variability in patient data, limited access to specialized diagnostic tests, and overreliance on single-type indicators. These challenges are…

Quantitative Methods · Quantitative Biology 2025-03-05 Yizong Xing , Dhita Putri Pratama , Yuke Wang , Yufan Zhang , Brian E. Chapman

Large Language Models (LLMs), AI models trained on massive text corpora with remarkable language understanding and generation capabilities, are transforming the field of Autonomous Driving (AD). As AD systems evolve from rule-based and…

Artificial Intelligence · Computer Science 2024-07-30 Yun Li , Kai Katsumata , Ehsan Javanmardi , Manabu Tsukada

In the past two years, large language model (LLM)-based chatbots, such as ChatGPT, have revolutionized various domains by enabling diverse task completion and question-answering capabilities. However, their application in scientific…

Artificial Intelligence · Computer Science 2025-09-01 Tingxuan Xu , Jiarui Feng , Justin Melendez , Kaleigh Roberts , Donghong Cai , Mingfang Zhu , Donald Elbert , Yixin Chen , Randall J. Bateman

Alzheimer's disease (AD) has become one of the most significant health challenges in an aging society. The use of spoken language-based AD detection methods has gained prevalence due to their scalability due to their scalability. Based on…

Computation and Language · Computer Science 2024-12-02 Junan Li , Yunxiang Li , Yuren Wang , Xixin Wu , Helen Meng

Alzheimer's disease (AD) is an irreversible and progressive brain disease that can be stopped or slowed down with medical treatment. Language changes serve as a sign that a patient's cognitive functions have been impacted, potentially…

Computation and Language · Computer Science 2018-04-19 Sweta Karlekar , Tong Niu , Mohit Bansal

Automated diagnosis of Alzheimer Disease(AD) from brain imaging, such as magnetic resonance imaging (MRI), has become increasingly important and has attracted the community to contribute many deep learning methods. However, many of these…

Image and Video Processing · Electrical Eng. & Systems 2024-03-01 Yifeng Wang , Ke Chen , Haohan Wang

Alzheimer's disease and related dementias(ADRD) affect nearly five million older adults in the United States, yet more than half remain undiagnosed. Speech-based natural language processing(NLP) offers a scalable approach for detecting…

An important issue impacting healthcare is a lack of available experts. Machine learning (ML) models could resolve this by aiding in diagnosing patients. However, creating datasets large enough to train these models is expensive. We…

Computation and Language · Computer Science 2024-05-14 Chancellor R. Woolsey , Prakash Bisht , Joshua Rothman , Gondy Leroy

Compared to other clinical screening techniques, speech-and-language-based automated Alzheimer's disease (AD) detection methods are characterized by their non-invasiveness, cost-effectiveness, and convenience. Previous studies have…

Audio and Speech Processing · Electrical Eng. & Systems 2024-12-10 Yin-Long Liu , Rui Feng , Jia-Hong Yuan , Zhen-Hua Ling

Large Language Models (LLMs), typified by OpenAI's GPT, have marked a significant advancement in artificial intelligence. Trained on vast amounts of text data, LLMs are capable of understanding and generating human-like text across a…

Artificial Intelligence · Computer Science 2024-10-29 Haochen Zhang , Yuyang Dong , Chuan Xiao , Masafumi Oyamada

Background: Alzheimer's disease (AD) diagnosis heavily relies on amyloid-beta positron emission tomography (Abeta-PET), which is limited by high cost and limited accessibility. This study explores whether Abeta-PET spatial patterns can be…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Zhengjie Zhang , Xiaoxie Mao , Qihao Guo , Shaoting Zhang , Qi Huang , Mu Zhou , Fang Xie , Mianxin Liu

Objective: To demonstrate the capabilities of Large Language Models (LLMs) as autonomous agents to reproduce findings of published research studies using the same or similar dataset. Materials and Methods: We used the "Quick Access" dataset…

Computation and Language · Computer Science 2025-06-02 Nic Dobbins , Christelle Xiong , Kristine Lan , Meliha Yetisgen