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The Finite State Projection (FSP) method approximates the Chemical Master Equation (CME) by restricting the dynamics to a finite subset of the (typically infinite) state space, enabling direct numerical solution with computable error…

Computational Engineering, Finance, and Science · Computer Science 2026-05-26 Aditya Dendukuri , Shivkumar Chandrasekaran , Linda Petzold

The chemical master equation (CME) is frequently used in systems biology to quantify the effects of stochastic fluctuations that arise due to biomolecular species with low copy numbers. The CME is a system of ordinary differential equations…

Quantitative Methods · Quantitative Biology 2017-10-25 Ankit Gupta , Jan Mikelson , Mustafa Khammash

Error estimates for the numerical solution of the master equation are presented. Estimates are based on adjoint methods. We find that a good estimate can often be computed without spending computational effort on a dual problem. Estimates…

Numerical Analysis · Mathematics 2016-10-12 Katharina Kormann , Shev MacNamara

We consider a Markov process in continuous time with a finite number of discrete states. The time-dependent probabilities of being in any state of the Markov chain are governed by a set of ordinary differential equations, whose dimension…

Optimization and Control · Mathematics 2014-10-31 Fernando Lopez-Caamal , Tatiana T. Marquez-Lago

We introduce the exit time finite state projection (ETFSP) scheme, a truncation-based method that yields approximations to the exit distribution and occupation measure associated with the time of exit from a domain (i.e., the time of first…

Probability · Mathematics 2019-10-31 Juan Kuntz , Philipp Thomas , Guy-Bart Stan , Mauricio Barahona

Estimation of physical observables for unknown quantum states is an important problem that underlies a wide range of fields, including quantum information processing, quantum physics, and quantum chemistry. In the context of quantum…

Quantum Physics · Physics 2024-05-21 Yuma Nakamura , Yoshichika Yano , Nobuyuki Yoshioka

The discrete chemical master equation (dCME) provides a general framework for studying stochasticity in mesoscopic reaction networks. Since its direct solution rapidly becomes intractable due to the increasing size of the state space,…

Quantitative Methods · Quantitative Biology 2017-07-27 Youfang Cao , Anna Terebus , Jie Liang

Accurate state preparation is a critical bottleneck in many quantum algorithms, particularly those for ground state energy estimation. Even in fault-tolerant quantum computing, preparing a quantum state with sufficient overlap to the…

Quantum Physics · Physics 2025-10-07 Gwonhak Lee , Minhyeok Kang , Jungsoo Hong , Stepan Fomichev , Joonsuk Huh

Due to the lack of state dimension optimization methods, deep state space models (SSMs) have sacrificed model capacity, training search space, or stability to alleviate computational costs caused by high state dimensions. In this work, we…

Machine Learning · Computer Science 2025-02-03 Minseon Gwak , Seongrok Moon , Joohwan Ko , PooGyeon Park

Stochastic models of chemical systems are often analysed by solving the corresponding Fokker-Planck equation which is a drift-diffusion partial differential equation for the probability distribution function. Efficient numerical solution of…

Numerical Analysis · Mathematics 2011-11-10 Simon L. Cotter , Tomas Vejchodsky , Radek Erban

This research focuses on solving time-dependent partial differential equations (PDEs), in particular the time-dependent Schr\"odinger equation, using matrix product states (MPS). We propose an extension of Hermite Distributed Approximating…

Quantum Physics · Physics 2026-03-18 Jorge Gidi , Paula García-Molina , Luca Tagliacozzo , Juan José García-Ripoll

Numerical solution of the chemical master equation for stochastic reaction networks typically suffers from the state space explosion problem due to the curse of dimensionality and from stiffness due to multiple time scales. The dimension of…

Molecular Networks · Quantitative Biology 2019-07-25 Linar Mikeev , Werner Sandmann

The discrete chemical master equation (dCME) provides a fundamental framework for studying stochasticity in mesoscopic networks. Because of the multi-scale nature of many networks where reaction rates have large disparity, directly solving…

Quantitative Methods · Quantitative Biology 2017-07-27 Youfang Cao , Anna Terebus , Jie Liang

Quantum state estimation is important for various quantum information processes, including quantum communications, computation, and metrology, which require the characterization of quantum states for evaluation and optimization. We present…

Quantum Physics · Physics 2026-04-15 C. Vargas , L. Pereira , A. Delgado

In this paper, we consider the finite-state approximation of a discrete-time constrained Markov decision process (MDP) under the discounted and average cost criteria. Using the linear programming formulation of the constrained discounted…

Optimization and Control · Mathematics 2018-07-10 Naci Saldi

Quantum simulation of molecular electronic structure is one of the most promising applications of quantum computing. However, achieving chemically accurate predictions for strongly correlated systems requires quantum phase estimation (QPE)…

Quantum Physics · Physics 2026-03-31 Shota Kanasugi , Riki Toshio , Kazunori Maruyama , Hirotaka Oshima

Stochastic reaction networks are a fundamental model to describe interactions between species where random fluctuations are relevant. The master equation provides the evolution of the probability distribution across the discrete state space…

Molecular Networks · Quantitative Biology 2021-06-15 Tabea Waizmann , Luca Bortolussi , Andrea Vandin , Mirco Tribastone

The efficiency of exact simulation methods for the reaction-diffusion master equation (RDME) is severely limited by the large number of diffusion events if the mesh is fine or if diffusion constants are large. Furthermore, inherent…

Numerical Analysis · Computer Science 2015-06-15 Andreas Hellander , Michael Lawson , Brian Drawert , Linda Petzold

Several Bayesian estimation based heuristics have been developed to perform quantum state tomography (QST). Their ability to quantify uncertainties using region estimators and include a priori knowledge of the experimentalists makes this…

Quantum Physics · Physics 2021-09-16 Syed Muhammad Kazim , Ahmad Farooq , Junaid ur Rehman , Hyundong Shin

Finite-state models, such as finite-state machines (FSMs), aid software engineering in many ways. They are often used in formal verification and also can serve as visual software models. The latter application is associated with the…

Software Engineering · Computer Science 2016-11-22 Vladimir Ulyantsev , Igor Buzhinsky , Anatoly Shalyto
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