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Histopathological images contain abundant phenotypic information and pathological patterns, which are the gold standards for disease diagnosis and essential for the prediction of patient prognosis and treatment outcome. In recent years,…

Computer Vision and Pattern Recognition · Computer Science 2022-10-26 Linhao Qu , Siyu Liu , Xiaoyu Liu , Manning Wang , Zhijian Song

The precise categorization of white blood cell (WBC) is crucial for diagnosing blood-related disorders. However, manual analysis in clinical settings is time-consuming, labor-intensive, and prone to errors. Numerous studies have employed…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Yuzhuo Chen , Zetong Chen , Yunuo An , Chenyang Lu , Xu Qiao

Breast Cancer is the most common cancer among women, which is also visible in men, and accounts for more than 1 in 10 new cancer diagnoses each year. It is also the second most common cause of women who die from cancer. Hence, it…

Image and Video Processing · Electrical Eng. & Systems 2023-10-17 Kanan Mahammadli , Abdullah Burkan Bereketoglu , Ayse Gul Kabakci

It is well known that in a supervised classification setting when the number of features is smaller than the number of observations, Fisher's linear discriminant rule is asymptotically Bayes. However, there are numerous modern applications…

Machine Learning · Statistics 2014-09-17 Irina Gaynanova , James G. Booth , Martin T. Wells

In standard hospital blood tests, the traditional process requires doctors to manually isolate leukocytes from microscopic images of patients' blood using microscopes. These isolated leukocytes are then categorized via automatic leukocyte…

Computer Vision and Pattern Recognition · Computer Science 2024-01-11 Yifei Chen , Chenyan Zhang , Ben Chen , Yiyu Huang , Yifei Sun , Changmiao Wang , Xianjun Fu , Yuxing Dai , Feiwei Qin , Yong Peng , Yu Gao

Computer-assisted surgery research requires large, deeply annotated video datasets that capture clinical and technical variability. Existing cataract surgery resources lack the diversity and annotation depth required to train generalizable…

Classification models that provide human-interpretable explanations enhance clinicians' trust and usability in medical image diagnosis. One research focus is the integration and prediction of pathology-related visual attributes used by…

Computer Vision and Pattern Recognition · Computer Science 2025-08-04 Luisa Gallée , Catharina Silvia Lisson , Christoph Gerhard Lisson , Daniela Drees , Felix Weig , Daniel Vogele , Meinrad Beer , Michael Götz

Patch classification models based on deep learning have been utilized in whole-slide images (WSI) of H&E-stained tissue samples to assist pathologists in grading follicular lymphoma patients. However, these approaches still require…

Accurate cell counting is essential in various biomedical research and clinical applications, including cancer diagnosis, stem cell research, and immunology. Manual counting is labor-intensive and error-prone, motivating automation through…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Abdurahman Ali Mohammed , Catherine Fonder , Ying Wei , Wallapak Tavanapong , Donald S Sakaguchi , Qi Li , Surya K. Mallapragada

Complementary-label learning (CLL) is a weakly-supervised learning paradigm that aims to train a multi-class classifier using only complementary labels, which indicate classes to which an instance does not belong. Despite numerous…

Machine Learning · Computer Science 2025-06-17 Hsiu-Hsuan Wang , Tan-Ha Mai , Nai-Xuan Ye , Wei-I Lin , Hsuan-Tien Lin

We train a machine learning model on a dataset of 2177 individuals using as features 26 probe sets and their age in order to classify if someone has acute myeloid leukaemia or is healthy. The dataset is multicentric and consists of data…

Machine Learning · Computer Science 2021-08-18 A. Angelakis , I. Soulioti

Lung cancer is the deadliest type of cancer worldwide and late detection is the major factor for the low survival rate of patients. Low dose computed tomography has been suggested as a potential screening tool but manual screening is…

Tuberculosis (TB) remains one of the leading causes of mortality worldwide, particularly in resource-limited countries. Chest X-ray (CXR) imaging serves as an accessible and cost-effective diagnostic tool but requires expert interpretation,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-15 Marshal Ashif Shawkat , Moidul Hasan , Taufiq Hasan

Leukemia epitomizes the class of highly complex diseases that new technologies aim to tackle by using large sets of single-cell level information. Achieving such goal depends critically not only on experimental techniques but also on…

Quantitative Methods · Quantitative Biology 2014-06-02 Jose M. G. Vilar

Microscopic evaluation of white blood cell morphology is central to leukemia diagnosis, yet current deep learning models often act as black boxes, limiting clinical trust and adoption. We introduce HemBLIP, a vision language model designed…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Julie van Logtestijn , Petru Manescu

Manual annotation of medical images is highly subjective, leading to inevitable and huge annotation biases. Deep learning models may surpass human performance on a variety of tasks, but they may also mimic or amplify these biases. Although…

Computer Vision and Pattern Recognition · Computer Science 2022-03-23 Zehui Liao , Shishuai Hu , Yutong Xie , Yong Xia

Large Language Models (LLMs) annotated datasets are widely used nowadays, however, large-scale annotations often show biases in low-quality datasets. For example, Multiple-Choice Questions (MCQs) datasets with one single correct option is…

Computation and Language · Computer Science 2026-01-08 Zipeng Ling , Shuliang Liu , Yuehao Tang , Chen Huang , Gaoyang Jiang , Shenghong Fu , Junqi Yang , Yao Wan , Jiawan Zhang , Kejia Huang , Xuming Hu

Recent advances in artificial intelligence, including the development of highly sophisticated large language models (LLM), have proven beneficial in many real-world applications. However, evidence of inherent bias encoded in these LLMs has…

Computation and Language · Computer Science 2023-09-19 Vithya Yogarajan , Gillian Dobbie , Timothy Pistotti , Joshua Bensemann , Kobe Knowles

Machine learning has endless applications in the health care industry. White blood cell classification is one of the interesting and promising area of research. The classification of the white blood cells plays an important part in the…

Computer Vision and Pattern Recognition · Computer Science 2021-12-14 Nalla Praveen , Narinder Singh Punn , Sanjay Kumar Sonbhadra , Sonali Agarwal , M. Syafrullah , Krisna Adiyarta

Breast cancer remains a global challenge, causing over 1 million deaths globally in 2018. To achieve earlier breast cancer detection, screening x-ray mammography is recommended by health organizations worldwide and has been estimated to…