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Ever since deoxyribonucleic acid (DNA) was considered as a next-generation data-storage medium, lots of research efforts have been made to correct errors occurred during the synthesis, storage, and sequencing processes using error…

Information Theory · Computer Science 2023-06-14 Jaeho Jeong , Hosung Park , Hee-Youl Kwak , Jong-Seon No , Hahyeon Jeon , Jeong Wook Lee , Jae-Won Kim

DNA storage systems face significant challenges, including insertion, deletion, and substitution (IDS) errors. Therefore, designing effective synchronization codes, i.e., codes capable of correcting IDS errors, is essential for DNA storage…

Information Theory · Computer Science 2025-05-23 Javad Haghighat , Tolga M. Duman

In this paper, we study error exponents for a concatataned coding based class of DNA storage codes in which the number of reads performed can be variable. That is, the decoder can sequentially perform reads and choose whether to output the…

Information Theory · Computer Science 2025-04-25 Yan Hao Ling , Nir Weinberger , Jonathan Scarlett

DNA-based data storage has been attracting significant attention due to its extremely high data storage density, low power consumption, and long duration compared to conventional data storage media. Despite the recent advancements in DNA…

Information Theory · Computer Science 2024-11-12 Yi Ding , Xuan He , Tuan Thanh Nguyen , Wentu Song , Zohar Yakhini , Eitan Yaakobi , Linqiang Pan , Xiaohu Tang , Kui Cai

DNA has emerged as a promising alternative for long-term data storage due to its high capacity, durability, and low-energy potential. However, storing data in DNA presents several challenges. First, it requires complex and costly…

Other Quantitative Biology · Quantitative Biology 2025-11-20 Sara Al Sayyed , Aline Roumy , Thomas Maugey

DNA-based storage is an emerging technology that enables digital information to be archived in DNA molecules. This method enjoys major advantages over magnetic and optical storage solutions such as exceptional information density, enhanced…

Information Theory · Computer Science 2024-03-13 Daniella Bar-Lev , Itai Orr , Omer Sabary , Tuvi Etzion , Eitan Yaakobi

We describe a strategy for constructing codes for DNA-based information storage by serial composition of weighted finite-state transducers. The resulting state machines can integrate correction of substitution errors; synchronization by…

Information Theory · Computer Science 2016-11-18 Ian Holmes

We consider error-correcting coding for deoxyribonucleic acid (DNA)-based storage using nanopore sequencing. We model the DNA storage channel as a sampling noise channel where the input data is chunked into $M$ short DNA strands, which are…

Information Theory · Computer Science 2024-06-21 Lorenz Welter , Roman Sokolovskii , Thomas Heinis , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

Constrained codes are used to eliminate error-prone patterns in various practical systems. Recently, we introduced efficient binary symmetric lexicographically-ordered constrained (LOCO) codes and asymmetric LOCO (A-LOCO) codes to increase…

Information Theory · Computer Science 2020-10-20 Jessica Centers , Xinyu Tan , Ahmed Hareedy , Robert Calderbank

This paper extends the foundational work of Dollma \emph{et al}. on codes for ordered composite DNA sequences. We consider the general setting with an alphabet of size $q$ and a resolution parameter $k$, moving beyond the binary ($q=2$)…

Information Theory · Computer Science 2026-02-19 Zuo Ye , Yuling Li , Zhaojun Lan , Gennian Ge

DNA is an attractive candidate for data storage. Its millennial durability and nanometer scale offer exceptional data density and longevity. Its relevance to medical applications also drives advances in DNA-related biotechnology. To protect…

Information Theory · Computer Science 2025-11-25 Yu-Ting Lin , Hsin-Po Wang , Venkatesan Guruswami

DNA data storage offers a high-density, long-term alternative to traditional storage systems, addressing the exponential growth of digital data. Composite DNA extends this paradigm by leveraging mixtures of nucleotides to increase storage…

Information Theory · Computer Science 2026-02-13 Busra Tegin , Tolga M Duman

In modern age, the increasing complexity of computation and communication technology is leading us towards the necessity of new paradigm. As a result, unconventional approach like DNA coding theory is gaining considerable attention. The…

Information Theory · Computer Science 2023-08-07 Mandrita Mondal , Kumar S. Ray

Motivated by average-case trace reconstruction and coding for portable DNA-based storage systems, we initiate the study of \emph{coded trace reconstruction}, the design and analysis of high-rate efficiently encodable codes that can be…

Information Theory · Computer Science 2019-09-11 Mahdi Cheraghchi , Ryan Gabrys , Olgica Milenkovic , João Ribeiro

We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random…

Emerging Technologies · Computer Science 2015-07-08 S. M. Hossein Tabatabaei Yazdi , Han Mao Kiah , Eva Ruiz Garcia , Jian Ma , Huimin Zhao , Olgica Milenkovic

Motivated by DNA-based data storage, we investigate a system where digital information is stored in an unordered set of several vectors over a finite alphabet. Each vector begins with a unique index that represents its position in the whole…

Information Theory · Computer Science 2019-01-23 Andreas Lenz , Paul H. Siegel , Antonia Wachter-Zeh , Eitan Yaakobi

Living in the age of the digital media explosion, the amount of data that is being stored increases dramatically. However, even if existing storage systems suggest efficiency in capacity, they are lacking in durability. Hard disks, flash,…

Image and Video Processing · Electrical Eng. & Systems 2019-04-08 Melpomeni Dimopoulou , Marc Antonini , Pascal Barbry , Raja Appuswamy

Constrained sequence (CS) codes, including fixed-length CS codes and variable-length CS codes, have been widely used in modern wireless communication and data storage systems. Sequences encoded with constrained sequence codes satisfy…

Information Theory · Computer Science 2019-06-17 Congzhe Cao , Duanshun Li , Ivan Fair

While achieving a compression ratio of 2.0 bits/base, the new algorithm codes non-N bases in fixed length. It dramatically reduces the time of coding and decoding than previous DNA compression algorithms and some universal compression…

Information Theory · Computer Science 2007-07-16 Jie Liu , Sheng Bao , Zhiqiang Jing , Shi Chen

The exponentially increasing demand for data storage has been facing more and more challenges during the past years. The energy costs that it represents are also increasing, and the availability of the storage hardware is not able to follow…

Image and Video Processing · Electrical Eng. & Systems 2022-03-21 Xavier Pic , Marc Antonini