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Physiologically Based Pharmacokinetic (PBPK) modeling is a cornerstone of model-informed drug development (MIDD), providing a mechanistic framework to predict drug absorption, distribution, metabolism, and excretion (ADME). Despite its…

Machine Learning · Computer Science 2026-02-24 Shunqi Liu , Han Qiu , Tong Wang

An exact approach to compute physical properties for general multi-electronic-state (MES) systems in thermal equilibrium is presented. The approach is extended from our recent progress on path integral molecular dynamics (PIMD) [J. Chem.…

Chemical Physics · Physics 2017-11-22 Xinzijian Liu , Jian Liu

Cyber-physical systems (CPS), in most instances, represent systems of systems with an informationally decentralized structure such as emerging mobility systems, networked control systems, sustainable manufacturing, smart power grids, power…

Optimization and Control · Mathematics 2024-05-15 Andreas Malikopoulos

Scientific machine learning (SciML) methods such as physics-informed neural networks (PINNs) are used to estimate parameters of interest from governing equations and small quantities of data. However, there has been little work in assessing…

Fluid Dynamics · Physics 2024-09-02 Alexander New , Marisel Villafañe-Delgado , Charles Shugert

Machine learning (ML) is the field of training machines to achieve high level of cognition and perform human-like analysis. Since ML is a data-driven approach, it seemingly fits into our daily lives and operations as well as complex and…

Machine Learning · Computer Science 2021-11-25 M. Z. Naser , Amir Alavi

Building Automation Systems (BAS) are exemplars of Cyber-Physical Systems (CPS), incorporating digital control architectures over underlying continuous physical processes. We provide a modular model library for BAS drawn from expertise…

Systems and Control · Computer Science 2018-04-18 Nathalie Cauchi , Alessandro Abate

The application of deep learning methods to speed up the resolution of challenging power flow problems has recently shown very encouraging results. However, power system dynamics are not snap-shot, steady-state operations. These dynamics…

Machine Learning · Computer Science 2022-06-22 Mostafa Mohammadian , Kyri Baker , Ferdinando Fioretto

Building Information Modeling (BIM) describes a central data pool covering the entire life cycle of a construction project. Similarly, Building Energy Modeling (BEM) describes the process of using a 3D representation of a building as a…

Human-Computer Interaction · Computer Science 2025-02-06 Andreas Walch , Attila Szabo , Harald Steinlechner , Thomas Ortner , Eduard Gröller , Johanna Schmidt

We propose a new physics guided machine learning (PGML) paradigm that leverages the variational multiscale (VMS) framework and available data to dramatically increase the accuracy of reduced order models (ROMs) at a modest computational…

Fluid Dynamics · Physics 2022-05-26 Shady E. Ahmed , Omer San , Adil Rasheed , Traian Iliescu , Alessandro Veneziani

More accurate, spatio-temporally, and physically consistent LST estimation has been a main interest in Earth system research. Developing physics-driven mechanism models and data-driven machine learning (ML) models are two major paradigms…

Atmospheric and Oceanic Physics · Physics 2023-07-12 Jun Ma , Huanfeng Shen , Menghui Jiang , Liupeng Lin , Chunlei Meng , Chao Zeng , Huifang Li , Penghai Wu

Dynamical systems that evolve continuously over time are ubiquitous throughout science and engineering. Machine learning (ML) provides data-driven approaches to model and predict the dynamics of such systems. A core issue with this approach…

Machine Learning · Computer Science 2023-11-23 Aditi S. Krishnapriyan , Alejandro F. Queiruga , N. Benjamin Erichson , Michael W. Mahoney

The utilization of Deep Neural Networks (DNNs) in physical science and engineering applications has gained traction due to their capacity to learn intricate functions. While large datasets are crucial for training DNN models in fields like…

Machine Learning · Computer Science 2025-08-05 Vamsi Sai Krishna Malineni , Suresh Rajendran

With the popularity of electric vehicles, the demand for lithium-ion batteries is increasing. Temperature significantly influences the performance and safety of batteries. Battery thermal management systems can effectively control the…

Machine Learning · Computer Science 2026-01-07 Zheng Liu , Yuan Jiang , Yumeng Li , Pingfeng Wang

Physics-Informed Neural Networks (PINNs) have emerged as a powerful tool for solving partial differential equations~(PDEs) in various scientific and engineering domains. However, traditional PINN architectures typically rely on large, fully…

Computational Engineering, Finance, and Science · Computer Science 2024-04-22 Stefano Markidis

Physics-based and data-driven models for remaining useful lifetime (RUL) prediction typically suffer from two major challenges that limit their applicability to complex real-world domains: (1) incompleteness of physics-based models and (2)…

Systems and Control · Electrical Eng. & Systems 2020-10-28 Manuel Arias Chao , Chetan Kulkarni , Kai Goebel , Olga Fink

Heating, Ventilation, and Air-Conditioning (HVAC) systems account for a substantial share of global building energy use, making reliable anomaly detection essential for improving efficiency and reducing emissions. Classical rule-based…

Artificial Intelligence · Computer Science 2025-10-21 Subin Lin , Chuanbo Hua

As in many other areas of engineering and applied science, Machine Learning (ML) is having a profound impact in the domain of Weather and Climate Prediction. A very recent development in this area has been the emergence of fully data-driven…

Machine Learning · Statistics 2023-11-06 Massimo Bonavita

In this paper, we provide two case studies to demonstrate how artificial intelligence can empower civil engineering. In the first case, a machine learning-assisted framework, BRAILS, is proposed for city-scale building information modeling.…

Computer Vision and Pattern Recognition · Computer Science 2020-08-25 Qian Yu , Chaofeng Wang , Barbaros Cetiner , Stella X. Yu , Frank Mckenna , Ertugrul Taciroglu , Kincho H. Law

A main driver behind the digitization of industry and society is the belief that data-driven model building and decision making can contribute to higher degrees of automation and more informed decisions. Building such models from data often…

Physics-Informed Neural Networks (PINNs) have recently emerged as a novel approach to simulate complex physical systems on the basis of both data observations and physical models. In this work, we investigate the use of PINNs for various…

Analysis of PDEs · Mathematics 2024-03-27 Guillaume Coulaud , Maxime Le , Régis Duvigneau
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